Navigation Links
Bacteria battle against toxic fluoride
Date:12/22/2011

Regular use of fluoride-containing toothpaste and mouthwash has long been known to strengthen the enamel on teeth. But new research by Howard Hughes Medical Institute (HHMI) scientists finds that fluoride also has dramatic effects on bacteria inside the mouth -- including those that form plaque and can cause cavities.

HHMI researcher Ronald Breaker of Yale University has discovered the cellular chain of events that occurs inside a bacterium after it encounters fluoride in its environment. His team's findings reveal that many bacteria try to fend off fluoride which the organisms treat as a toxic substance by throwing it out. The presence of such a transport system indicates that fluoride itself has antimicrobial properties, Breaker said. The findings are published online in Science Express on December 22, 2011.

Breaker's lab studies non-coding RNA, stretches of genetic material that play regulatory roles in the cell instead of coding for proteins. Using different computer algorithms, he and his colleagues analyze the genomes of organisms to identify signature sequences in genetic material that likely indicate the presence of noncoding RNA. Among the types of non-coding RNAs they find are regulatory molecules called riboswitches. Normally, the role of a riboswitch is easy to deduce: Riboswitches are attached to the genes that they regulate. If the gene is needed to produce a certain compound, the riboswitch is usually sensitive to that compound, so when its level increases or decreases in the cell, the riboswitch can cause more or less to be made. Aside from their interest in the biology of riboswitches, Breaker's group is studying these genetic switches because they could represent new drug targets and might be used to control the activity of genes inserted into cells as gene therapies.

In a recent set of experiments, Breaker's team identified a new riboswitch that was attached to a handful of genes with vague or unknown functions. They w
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Disinfectants can make bacteria resistant to treatment
2. H. Pylori bacteria may help prevent some esophageal cancers
3. Scientists discover bacteria that can cause bone infections
4. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
5. Gene against bacterial attack unravelled
6. Predatory bacterial swarm uses rippling motion to reach prey
7. Bacteria manage perfume oil production from grass
8. Nature study demonstrates that bacterial clotting depends on clustering
9. Battling bacteria in the blood: Researchers tackle deadly infections
10. Shifts in soil bacterial populations linked to wetland restoration success
11. New bacteria discovered in raw milk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... MOUNTAIN VIEW, Calif. , Dec. 18, 2014  23andMe, Inc., ... a study that pinpoints fine-scale differences in genetic ancestry of ... Since immigrants first arrived more than four hundred ... served as a meeting place for peoples from different continents. ...
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... to their offering. One major trend ... biometric systems. Multimodal biometric systems utilize more than one ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... from amniotic fluid were used to restore gut structure and ... in the journal Gut . The findings pave the ... serious damage from inflammation in the intestines of babies. ... investigated a new way to treat necrotizing enterocolitis (NEC), where ...
... sounds from whales and other marine mammals, using a variety ... how these animals use sound to interact with each other ... report using this technology to record spawning cod in the ... for several decades, but few studies have observed their use ...
... Catching rides on cargo ships and fishing boats, many invasive ... of our native marine life. , In a study published ... and his team examine what factors allow some invasive species ... WHY SHOULD WE CARE? Once ...
Cached Biology News:Amniotic fluid stem cells repair gut damage 2Acoustic monitoring of Atlantic cod reveals clues to spawning behavior 2Acoustic monitoring of Atlantic cod reveals clues to spawning behavior 3Invasive species: Understanding the threat before it's too late 2
(Date:1/22/2015)... 2015  Derma Sciences, Inc. (Nasdaq: DSCI ... wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic ... to the Premier, Inc. Regenerative Skin Grafting contract ... AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue to ...
(Date:12/24/2014)... Texas , Dec. 24, 2014  Vermillion, Inc. ... on gynecologic disease, announced today that the Company ... including Oracle Investment Management, Jack W. Schuler ... Total proceeds were $10.5 million, before offering expenses.  ...
(Date:12/24/2014)... 2014 Earlier this year in a June ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... property of adult tissue stem cells. His title “Asymmetric ... for the Future,” embodied the essence of his message to ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 The ... as its definition, classification, application and industry overview. ... and product cost structure. Production is separated by ... upstream raw materials, equipment, downstream client survey, marketing ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... Research Campus as its newest tenant partner. The NC Research Campus ... Nine universities and colleges (including Duke University, UNC, and NC State)will have ... The Campus promises to be a world class center for industry and ... ...
... TorreyPines Therapeutics,Inc. (Nasdaq: TPTX ) today announced ... a Phase I multiple dose clinical trial of NGX426, ... The trial is,designed to evaluate the safety, tolerability and ... days. NGX426 has been,safely administered to more than 150 ...
... Lawrence A. Rheins Joins Histogen Aesthetics as President , ... ... a regenerative medicine company developing solutions based on the products of ... a venture developing products for the growing medical aesthetic industries based ...
Cached Biology Technology:Food and Beverage Giant Joins Kannapolis Research Center 2Food and Beverage Giant Joins Kannapolis Research Center 3Food and Beverage Giant Joins Kannapolis Research Center 4TorreyPines Therapeutics Begins Dosing in a Phase I Multiple Dose Clinical Trial of NGX426, Oral Prodrug of Tezampanel 2TorreyPines Therapeutics Begins Dosing in a Phase I Multiple Dose Clinical Trial of NGX426, Oral Prodrug of Tezampanel 3TorreyPines Therapeutics Begins Dosing in a Phase I Multiple Dose Clinical Trial of NGX426, Oral Prodrug of Tezampanel 4Histogen Aesthetics is Created to Address Growing Medical Aesthetics Market 2Histogen Aesthetics is Created to Address Growing Medical Aesthetics Market 3Histogen Aesthetics is Created to Address Growing Medical Aesthetics Market 4
... is used in conjuction with Annexin V-FITC ... earlier stages of apoptosis (Annexin V positive, ... later stages of apoptosis or already dead ... detected in the orange range of the ...
... RPMI 1640 with 2 mM L-glutamine and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
... CrysScreen is a software package ... user interface for custom buffer creation, ... management in crystallization trials. The software ... steps in automated protein crystallography: ...
... direct antibiotic-based selection system for recombinant identification. ... eliminating the need for costly color screening. ... to 100% accuracy in recombinant selection. pLivSelect ... colony picking. This cloning kit can be ...
Biology Products: