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Backstabbing bacteria: A new treatment for infection?
Date:9/5/2010

Selfish bacterial cells that act in their own interests and do not cooperate with their infection-causing colleagues can actually reduce the severity of infection.

The selfish behaviour of these uncooperative bacteria could be exploited to treat antibiotic-resistant infections, according to research being presented at the Society for General Microbiology's autumn meeting today.

Bacteria work together by using a well-studied communication system called Quorum Sensing (QS). During infection, bacteria talk to each other using QS to coordinate the release of toxins.

Researchers at the University of Nottingham have discovered that in Staphylococcus aureus infections, bacteria defective in QS can benefit from 'opting out' of toxin production. By doing so, they can invest more energy in reproducing whilst taking advantage of the nutrient-rich infection that is maintained by their neighbours.

By looking after themselves in this way, QS-deficient bacteria are quickly able to outnumber other bacteria that are busy producing toxins. As a result the overall severity of infection is reduced as fewer toxins are produced. "This opens up the interesting possibility of using these uncooperative bacteria to treat infection," said Mr Eric Pollitt who is presenting the study.

The group tested the theory by introducing S. aureus into waxworms that subsequently developed infections. "We found that the QS-deficient bacteria could not only outgrow normal bacteria in the same population, but that they could also invade other cooperating populations to reduce the severity of infection," explained Mr Pollitt. "This means that we could potentially isolate QS-deficient bacteria and use them to treat clinical S. aureus infections."

New approaches for the treatment of S. aureus infections are desperately needed as many strains of the bacterium, such as Meticillin-resistant Staphylococcus aureus (MRSA),
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Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

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