Navigation Links
Baby hearts need rhythm to develop correctly
Date:2/18/2014

lve leaflets.

One of the standard laboratory methods for studying the early stages of heart development is to use microsurgery to remove a chick heart from an embryo and place it in a cell-culture dish filled with collagen gel. However, the method was not suitable for studying mechanical forces so Sewell-Loftin had to modify it substantially. She found one key was to include a complex sugar called hyaluronic acid, which is found in cardiac jelly.

Next, she had to devise a method to measure the amount of deformation that the pulsation of the heart muscle cells causes in the gel. She did so by creating a computer program that analyzed sequences of microscope images of the gel surface to estimate the forces caused by the pulsing cells.

When Sewell-Loftin compared her maps with the locations where VICs were being formed, she found that cells were transforming preferentially in areas of high strain.

The team's next step is to collaborate with a researcher who works with induced pluripotent stem cells a type of stem cell that can be generated directly from adult cells to produce endothelial cells. Once they have these cells, they hope to produce human VICs. In addition to guiding the initial formation of the heart, VICs are known to play a role in maintaining valve health in adults. So they could provide a better way to repair calcified heart valves, the major cause of open-heart surgery in adults, the researchers speculate.

Once they can make human VICs, there is a good chance that they will create artificial human heart valves when they are placed in a properly designed bioreactor, the researchers anticipate. And once they have artificial human heart valves, they could be used to replace defective valves when needed in the 40,000 babies born with congenital heart defects each year. Hopefully, these artificial valves would grow with the child. Current replacement valves are made out of plastic so they do not grow with a chil
'/>"/>

Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Bio-inspired glue keeps hearts securely sealed
2. Putting the spring back in broken hearts
3. Do mens and womens hearts burn fuel differently?
4. Nanomaterials key to developing stronger artificial hearts
5. RUB researchers find over active enzyme in failing hearts
6. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
7. Researchers find our inner reptile hearts
8. Beat-keeping sea lion shows surprising rhythmic ability
9. Researchers discover how heart arrhythmia occurs
10. The internal clock and feeding rhythm set the pace of the liver
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Baby hearts need rhythm to develop correctly
(Date:12/17/2014)... Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ... – with the clinical data to back it up," ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... NEW YORK (January 14, 2008) Outbreaks of the notorious ... richest center of coral reef biodiversity on Earth, according to ... ARC Centre of Excellence for Coral Reef Studies. The ... its stomach over them and using digestive enzymes to liquefy ...
... Service Weekly PressPac with news from ACS 36 peer-reviewed journals ... the American Chemical Society as the source for this information. ... which is embargoed for 9 A. M., Eastern Time, Jan. ... Seagull blood shows promise for monitoring pollutants ...
... ARBOR, Mich.---An international study of 20,000 people found seven ... factor in heart disease, and confirmed 11 other genes ... international study led by researchers from the University of ... or confirm genetic variants that influence lipid levels, and ...
Cached Biology News:Starfish outbreak threatens corals 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 3American Chemical Society's weekly PressPac -- Jan. 9, 2008 4American Chemical Society's weekly PressPac -- Jan. 9, 2008 5American Chemical Society's weekly PressPac -- Jan. 9, 2008 6American Chemical Society's weekly PressPac -- Jan. 9, 2008 7American Chemical Society's weekly PressPac -- Jan. 9, 2008 8American Chemical Society's weekly PressPac -- Jan. 9, 2008 9Study locates cholesterol genes; finds surprises about good, bad cholesterol 2
(Date:12/19/2014)... Reports from CDC show ... from one or more chronic health conditions - including ... address some of these diseases, but may not eliminate ... face. While implanted nerve stimulation devices today offer relief, ... which can induce side effects. , To eliminate ...
(Date:12/19/2014)... Diego, CA (PRWEB) December 18, 2014 ... a limited time special on Sartorius Biohit products ... Free on mLINE pipettes, Picus Electronic Pipette Trade-in Program, ... by Health and Safety officers around the world. They ... manual pipetting. Other features include:, ,     Full ...
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... Achim Noack has been named global vice ... this position, Noack will assist Jerry Stoller, CEO and ... strategy and supervise global marketing management and implementation of ... knowledge and experience in the crop protection industry,” says ... innovative thinking will be a great asset for Stoller ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... Call on Thursday, November 5, 2009 at 4:30 p.m. ... /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. ("OncoGenex" or the "Company") ... for the third quarter and nine months ended September ... third quarter of 2009. , The following consolidated results ...
... Wound Management Technologies, Inc., (WNDM), announced today that it has ... assets of Virtual Health Technologies, Inc. (OTC Bulletin Board: VHGI). ... cash and debt, 4,000,000 shares of WNDM and a royalty ... being acquired from VHGI. WNDM closed at $2.00 ...
... Nov. 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) ... to release third quarter 2009 financial results on,Monday, November 9, ... The Company will hold a conference call at 5:00 pm ... Listeners may access the call by,dialing 1-888-713-4211 or 1-617-213-4864 ...
Cached Biology Technology:OncoGenex Reports Third Quarter 2009 Financial Results 2OncoGenex Reports Third Quarter 2009 Financial Results 3OncoGenex Reports Third Quarter 2009 Financial Results 4OncoGenex Reports Third Quarter 2009 Financial Results 5OncoGenex Reports Third Quarter 2009 Financial Results 6OncoGenex Reports Third Quarter 2009 Financial Results 7OncoGenex Reports Third Quarter 2009 Financial Results 8OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 2OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 3BMP Sunstone to Report Third Quarter 2009 Financial Results 2
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... Workstation for PCR set-up Easy ... to hold 0.2 ml PCR tubes, strips or Nunc ... handling systems Removable tray can be fitted ... V-bottom 0.2 ml tube block thermal cycler formats of ...
... in DMEM and harvested at the log phase ... antigens in their native forms, cells were fixed ... a 12-well (5 mm) adhesive coated slide, with ... attachment and to minimize background staining. Each ...
...
Biology Products: