Navigation Links
Baby hearts need rhythm to develop correctly
Date:2/18/2014

lve leaflets.

One of the standard laboratory methods for studying the early stages of heart development is to use microsurgery to remove a chick heart from an embryo and place it in a cell-culture dish filled with collagen gel. However, the method was not suitable for studying mechanical forces so Sewell-Loftin had to modify it substantially. She found one key was to include a complex sugar called hyaluronic acid, which is found in cardiac jelly.

Next, she had to devise a method to measure the amount of deformation that the pulsation of the heart muscle cells causes in the gel. She did so by creating a computer program that analyzed sequences of microscope images of the gel surface to estimate the forces caused by the pulsing cells.

When Sewell-Loftin compared her maps with the locations where VICs were being formed, she found that cells were transforming preferentially in areas of high strain.

The team's next step is to collaborate with a researcher who works with induced pluripotent stem cells a type of stem cell that can be generated directly from adult cells to produce endothelial cells. Once they have these cells, they hope to produce human VICs. In addition to guiding the initial formation of the heart, VICs are known to play a role in maintaining valve health in adults. So they could provide a better way to repair calcified heart valves, the major cause of open-heart surgery in adults, the researchers speculate.

Once they can make human VICs, there is a good chance that they will create artificial human heart valves when they are placed in a properly designed bioreactor, the researchers anticipate. And once they have artificial human heart valves, they could be used to replace defective valves when needed in the 40,000 babies born with congenital heart defects each year. Hopefully, these artificial valves would grow with the child. Current replacement valves are made out of plastic so they do not grow with a chil
'/>"/>

Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Bio-inspired glue keeps hearts securely sealed
2. Putting the spring back in broken hearts
3. Do mens and womens hearts burn fuel differently?
4. Nanomaterials key to developing stronger artificial hearts
5. RUB researchers find over active enzyme in failing hearts
6. Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
7. Researchers find our inner reptile hearts
8. Beat-keeping sea lion shows surprising rhythmic ability
9. Researchers discover how heart arrhythmia occurs
10. The internal clock and feeding rhythm set the pace of the liver
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Baby hearts need rhythm to develop correctly
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... Jan. 22, 2015   EyeLock, Inc. , a market leader ... Steve Gerber to the new role of Senior ... for leading development of mobile platforms and wearable solutions for ... and innovation in the semiconductor industry to his role at ...
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... may be just what the doctor orders for individuals suffering ... production or altered tear film composition. According to a study ... temperature less than 30 degrees Celsius on the eye and ... of the disorder. The study, (Meibomian Lipid Films and ...
... from the Swedish medical university Karolinska Institutet has deepened ... most fundamental processes, works. In a long term perspective ... The study is presented in the prestigious scientific journal ... yeast cells, researchers at Karolinska Institutet have discovered that ...
... Thursday, May 26, the University of Delaware will ... honor of Richard F. Heck, Willis F. Harrington ... of the 2010 Nobel Prize in Chemistry. Register ... Akira Suzuki of Japan,s Hokkaido University, and Ei-Ichi ...
Cached Biology News:Drop in temperature may explain the increase in dry eye suffering 2Research into chromosome replication reveals details of heredity dynamics 2Symposium honoring UD Nobel Laureate Richard Heck set for May 26 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited to ... on probiotics in San Diego, CA. , The Scripps ... health care professionals. This year’s pre-conference seminar was held on ... Dr. Leyer spoke about the emerging topics and science in ...
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
(Date:1/22/2015)... ALTO, Calif. , Jan. 22. 2015  Varian Medical Systems ... and software, has been honored for its commitment to sustainability ... sustainable companies. Varian is the highest ranked healthcare equipment company ... announced today during the World Economic Forum at ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Mass., May 2, 2011 Richard Resnick, GenomeQuest,s ... on Tuesday, May 3, 2011, at the Biomarker ... Next Generation/Whole-Genome Sequencing on Companion Diagnostics" for pharmaceutical ... generation sequencing and data management technologies. ...
... 2011 Dyadic International, Inc. ("Dyadic") (OTC Pink: ... discovery, development, manufacture and sale of enzyme and ... enzyme industries, announced today that its research and ... entered into a research agreement with Sanofi Pasteur, ...
... 2, 2011 Saladax Biomedical, Inc., a privately held ... the promise of personalized medicine for new and existing ... team to expand its European presence. Reporting ... members of Saladax,s European commercialization team include: ...
Cached Biology Technology:GenomeQuest to Lead Biomarker World Congress Panel on Applying Whole Genome Sequencing to Developing Companion Diagnostics 2Dyadic Netherlands Enters Into R&D Collaboration With Sanofi Pasteur and EnGen Bio 2Saladax Biomedical, Inc. Announces European Commercialization Team 2Saladax Biomedical, Inc. Announces European Commercialization Team 3
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
Goat polyclonal to HA1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: TLGSCRERQPEFV from the C terminus of human HA1. Entrez GeneID: 23526 Swiss Protein ID: O78181...
Mouse monoclonal [X223] to Lamin B1 + B2 - Nuclear Envelope Marker ( Abpromise for all tested applications). entrezGeneID: 4001 SwissProtID: P20700...
Biology Products: