Navigation Links
BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
Date:1/25/2013

(Boston) A new study from Boston University School of Medicine (BUSM) shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. The study, published online in Cell Stem Cell, demonstrates the potential of utilizing iPS cells to develop cell types that could offer treatment for a wide range of conditions, including diabetes, liver and lung diseases, without the barrier of immune rejection.

Ashleigh Boyd, DPhil, and Neil Rodrigues, DPhil, the study's senior authors, are assistant professors of dermatology at BUSM and researchers at the Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center (BMC). They also are lead investigators at the National Institutes of Health's Center of Biomedical Research Excellence (COBRE) at Roger Williams Medical Center, a clinical and research affiliate of BUSM.

iPS cells can be developed from adult cell types, such as skin or blood, by returning them to a stem cell state using genetic manipulation. iPS cells are capable of maturing (differentiating) into all the specific cell types in the body, making them a powerful tool for biological research and a source of tissues for transplantation based therapies. Given that iPS cells can be made in a patient-specific manner, there should be great potential for them to be transplanted back into the same patient without rejection. Yet a study published in Nature in 2011 demonstrated that iPS cells transplanted in the stem cell state were rejected in genetically identical recipients.

"The Nature study provocatively suggested that tissues derived from patient-specific iPS cells may be immunogenic after transplantation. However, it never directly assessed the immunogenicity of the therapeutically relevant cell types that could be utilized in regenerative medicine and transplantation," said Rodrigues.

The
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... natural habitats and trees and not just asphalt and ... a University of Colorado Boulder study. , Working on ... stress-reducing benefits for youth, according to a paper published ... study is one of the first of its kind ... green settings and stress. , "Many schools already offer ...
(Date:7/22/2014)... a child,s lunch box and you,re likely to find that ... Those are the findings of a study conducted by researchers ... Tufts University and in the Department of Public Health and ... findings are published online ahead of print in the ... , Led by senior author Jeanne Goldberg, Ph.D., R.D., a ...
(Date:7/22/2014)... 22, 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric ... announces its next generation smart wallet, Wocket™, will be featured ... show that airs on the History Channel, FYI ... regularly features top technology products and services. The ... History Channel (6:00-6:30am ET/PT) and the FYI Network ...
Breaking Biology News(10 mins):Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3Room for improvement in elementary school children's lunches and snacks from home 2NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 2NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 3
... EUGENE, Ore.(Aug. 20, 2007)Nitric acid is a notoriously strong and ... our atmosphere. However, a team of researchers have found that ... top of a water surface. The discovery of the ... the surface of water requires us to re-evaluate how we ...
... of G&D, Drs. Maria Divina Deato and Robert Tjian ... alternative transcriptional core promoter complex directs cell-type specific differentiation ... of transcriptional control of terminal cell differentiation, and will ... date at www.genesdev.org . For nearly 30 ...
... after prior full-dose conventional radiation therapy respond to Boron ... a Phase I/II study at the Helsinki University Hospital, ... Heikki Joensuu, University of Helsinki, considers the results ... field for BNCT, since thus far BNCT has been ...
Cached Biology News:University of Oregon researcher finds that on water's surface, nitric acid is not so tough 2A new radiation therapy treatment developed for head and neck cancer patients 2
(Date:7/21/2014)... to a chain of carbon atoms can turn it ... Rice University scientists. , Stretching the material known as ... -- by just 3 percent can begin to change ... for mechanically activated nanoscale electronics and optics. , The ... colleagues appears in the American Chemical Society journal ...
(Date:7/21/2014)... ALBANY, New York , July 21, 2014 ... up-to-date research on Global & USA ... Market Size, Trends, and Forecasts ResearchMoz ... USA  Cancer Biomaker Market   to 2018 (Identification, Technologies, ... Strategies, Industry Trends, and Pipeline Analysis. ...
(Date:7/19/2014)... NewYork (PRWEB) July 20, 2014 ... , Summary , GlobalDatas new report, "United States ... market data on the United States Non-Vascular Stents ... US dollars, volume (in units) and average prices ... Stents (Plastic Biliary Stents and Metal Biliary Stents ...
(Date:7/18/2014)... The world is mostly neutral. That is, most ... The number of electrons in the outer parts ... centers of atoms. As one or more electrons ... feel a much stronger positive pull from the nucleus. ... in size, ensures that those electrons are less vulnerable ...
Breaking Biology Technology:Carbyne morphs when stretched 2Carbyne morphs when stretched 3Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 2Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 3Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 4Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 5Global & USA Cancer Biomaker Market to 2018 (Identification, Technologies, Market Analysis, Competitor Profiles, Companion Diagnostic Co-Development, Business Strategies, Industry Trends, and Pipeline Analysis) - Market Size, Trends, and Forecasts A 6United States Non-Vascular Stents Market Outlook to 2020 | Researchmoz 2United States Non-Vascular Stents Market Outlook to 2020 | Researchmoz 3United States Non-Vascular Stents Market Outlook to 2020 | Researchmoz 4Highly charged ions 2Highly charged ions 3Highly charged ions 4
... MOUNT LAUREL, N.J. March 23 The ninth annual American ... the field of basic and clinical transplantation. This joint ... and the American Society of Transplantation ... at the John B. Hynes Convention Center in Boston, MA. ...
... Pharmaceuticals, Inc. (Nasdaq: ARNA ) announced today it ... million from Azimuth Opportunity Ltd. During the 18-month term of ... shares of its common stock to Azimuth Opportunity Ltd. at ... at its sole discretion, the timing and amount of any ...
... 23 Cell Therapeutics, Inc. (CTI) (NASDAQ and MTA: ... report on Form 10-K for the year ended December ... CTI,s website at www.CellTherapeutics.com , or on the ... .As required under NASDAQ Marketplace Rule 4350(b)(1)(B), CTI also ...
Cached Biology Technology:American Transplant Congress 2009 2Arena Pharmaceuticals Obtains Equity Financing Commitment of Up to $50 Million 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
Biology Products: