Navigation Links
BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
Date:12/21/2010

(Boston) Researchers from Boston University School of Medicine (BUSM) have demonstrated that certain T cells require input from monocytes in order to maintain their pro-inflammatory response in people with type 2 diabetes (T2D). The study also showed, for the first time, how a loss in homeostasis in this group of T cells most likely promotes chronic inflammation associated with T2D.

Barbara Nikolajczyk, PhD, an associate professor of microbiology and medicine at BUSM, is the senior author of the study, which is currently featured in an online edition of the Journal of Immunology.

T2D is a chronic inflammatory disease in which the body has high levels of glucose in the blood due to the lack of insulin or the body's inability to use insulin efficiently. The incidence of T2D continues to rise at alarming rates in both children and adults in the United States.

Previous research done in mice has shown that T cells play a critical role in the development of insulin resistance in response to a high fat diet, often leading to T2D. Additional findings indicate that T cells exhibit a pro-inflammatory response more often than an anti-inflammatory response.

Working with human T cells, the team observed that in order for T cells to exhibit the pro-inflammatory response, they required constant interaction with monocytes, indicating that monocytes play an indirect role in chronic inflammation and T2D.

While it is not known what the homeostatic balance levels are between pro-inflammatory and anti-inflammatory T cells, this study indicates the need to restore a balance in order to halt chronic inflammation and T2D.

"The true importance of our observations is the indication that altering balance among immune system cells could be a fundamentally novel treatment for T2D-associated inflammation and perhaps insulin resistance," said Nikolajczyk.


'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. The orange in your stocking: researchers squeezing out maximum health benefits
2. Researchers discover human immune system has emergency backup plan
3. Link between cholesterol compound and multiple sclerosis unlikely, researchers say
4. Researchers discover compound with potent effects on biological clock
5. UGA researchers develop rapid diagnostic test for common type of pneumonia
6. Freshwater sustainability challenges shared by Southwest and Southeast, researchers find
7. MGH researchers develop faster method of engineering zinc-finger nucleases
8. Researchers discover how natural drug fights inflammation
9. Researchers devise computer model for projecting severity of flu season
10. NIH awards $6.4 million to Case Western Reserve School of Medicine researchers
11. Researchers discover a way to delay Christmas tree needle loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... 2017 , ... Blood centers traditionally see a dangerous drop of blood donations ... struggle for community blood centers as high schools are out and many frequent donors ... is teaming up with the South Texas Blood & Tissue Center (STBTC), ...
(Date:7/18/2017)... ... July 18, 2017 , ... Recently ... ( https://dataformsoftware.com ) announces the migration of its flagship cloud-based product Planet Life ... a team-centric, enterprise work management system that merges strategic and financial planning with ...
(Date:7/17/2017)... ... 2017 , ... The Academy of Model Aeronautics (AMA) will host Aviation Adventure ... take place from 9 a.m. to 2 p.m. at the International Aeromodeling Center in ... Aviation Adventure Day will be packed with entertaining activities for the entire family. Attendees ...
(Date:7/17/2017)... ... 2017 , ... OHAUS Corporation, a leading worldwide manufacturer of ... line of Heavy-Duty Orbital Shakers today. , Eight New Models Available, OHAUS has ... These shakers are ideal for load capacities from 35 to 150 pounds, ...
Breaking Biology Technology: