Navigation Links
BUSM researchers identify molecule that could aid lung cancer detection, treatment
Date:10/25/2013

(Boston) Researchers at Boston University School of Medicine (BUSM) have discovered a molecule that could help lead to the non-invasive detection of lung cancer as well as its treatment. Using RNA sequencing, the team looked at airway epithelial cells and identified a regulatory molecule that was less abundant in people with lung cancer and inhibits lung cancer cell growth. The findings, which are published in the Proceedings of the National Academy of Sciences, suggest that this molecule may aid in diagnosing lung cancer in earlier stages and could potentially, when at healthy levels, aid in treating the disease.

According to the National Cancer Institute (NCI), lung cancer is the leading cause of cancer death among both men and women in the United States, and 90 percent of lung cancer deaths among men and approximately 80 percent of lung cancer deaths among women are due to smoking. The NCI also estimates that approximately 373,489 Americans are living with lung cancer and its treatment costs approximately $10.3 billion in the United States each year.

MicroRNA's are a new class of molecules classified as important regulators of the activity of other genes. In this study, the research team used a next-generation RNA sequencing technology and identified that a microRNA named miR-4423 in epithelial airway cells plays a major role in how these cells develop. In epithelial cells from the airway of smokers with lung cancer, levels of miR-4423 were decreased.

"These results suggest measuring the levels of microRNAs like miR-4423 in cells that line the airway could aid in lung cancer detection through a relatively non-invasive procedure," said Avrum Spira, MD, MSc, the Alexander Graham Bell professor of medicine and chief of the division of computational biomedicine at BUSM, one of the study's senior authors.

Using experimental models in vitro and in vivo, the research team demonstrated that miR-4423 can both promote the
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... , June 22, 2015 ... announced the addition of the "Huawei Ascend ... report to their offering. Huawei,s ... to the opposite direction than Apple,s and Samsung,s ... fingerprint sensor developed by Fingerprint Cards, a main ...
(Date:6/23/2015)... BEACH GARDENS, Fla. , June 23, ... multi-factor identity management and authentication solutions, today announced ... Altus strong, multi-factor authentication solution.  The enhancements ... of use of the DigitalPersona Altus platform ... biometric reader compatibility. In today,s ...
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... products, and in particular, wholegrain products, are important ... components which are beneficial for human health. Analysis ... the HEALTHGRAIN project of the European Union has ... content and composition of these components. Furthermore, a ...
... level of dietary protein are less likely to suffer ... is less, according to a new study by the ... an affiliate of Harvard Medical School. The study, which ... the Framingham Osteoporosis Study, found that individuals who were ...
... biologists has found that existing diversity in some coral ... disturbances such as those predicted from climate warming. ... species of algae living within corals may determine which ... The results will be published online in the ...
Cached Biology News:Dietary protein may reduce hip fractures in the elderly 2New study sheds light on corals' susceptibility to temperature change 2
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... June 30, 2015  NASA astronaut Kjell Lindgren , ... on his first mission to the International Space Station ... to 9 a.m. EDT Tuesday, July 7. Lindgren ... City, Russia . The interviews will be ... highlighting his mission training. To schedule an interview, ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... will provide new insights on mechanics of fecal microbiota transplantation in C. difficile ... study the microbiome of patients undergoing fecal microbiota transplantation (FMT) as a treatment ...
(Date:6/30/2015)... Oldsmar, FL (PRWEB) , ... June 30, 2015 , ... ... approximately 7.76% of Cryo-Cell’s currently outstanding common shares (including shares of unvested restricted stock). ... tender offer, the last sale price of Cryo-Cell’s shares reported on the OTCBB was ...
Breaking Biology Technology:Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3
... Sheets: NNLX) NanoLogix personnel will display the company,s BNP(TM) ... ASM Meeting to be held at the Pennsylvania Convention ... meeting is the world,s premier event for microbiology development. ... Bret Barnhizer. Exhibition information can be found at ...
... 5 Cadient Interactive , a ... custom-created digital campaigns, tools and services, today announced that ... team appointing Bethany (Beth) Hartzell to associate creative director. ... experts and digital thought leaders to provide unique and ...
... Consulting Corporation , an IT consulting and software ... SharePoint applications , announced today that it has ... biopharmaceutical company in the Boston area. The engagement ... data from a SharePoint 2003 environment to the Microsoft ...
Cached Biology Technology:NanoLogix Inc. to Exhibit at The American Society for Microbiology (ASM) General Meeting in Philadelphia; Announces Two New Patents 2NanoLogix Inc. to Exhibit at The American Society for Microbiology (ASM) General Meeting in Philadelphia; Announces Two New Patents 3Cadient Interactive Expands Creative Leadership with New Associate Director 2Syrinx Wins Contract with Leading Pharmaceutical Company for SharePoint 2007 Services 2
... Vacuum System UVS400 is a multi-tasking vacuum ... combines a refrigerated vapor trap and a ... integrated unit. The easy-to-use, wide-mouth glass condensation ... single jar for easy disposal. The UVS400 ...
Lysozyme C (W-20)...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
... BR4i refrigerated multifunction centrifuges are equally capable of ... low sound level with a large range of ... rotor exchange system without tools ensures that the ... Instant rotor exchange (5 sec.) ...
Biology Products: