Navigation Links
BUSM researchers identify molecule that could aid lung cancer detection, treatment
Date:10/25/2013

(Boston) Researchers at Boston University School of Medicine (BUSM) have discovered a molecule that could help lead to the non-invasive detection of lung cancer as well as its treatment. Using RNA sequencing, the team looked at airway epithelial cells and identified a regulatory molecule that was less abundant in people with lung cancer and inhibits lung cancer cell growth. The findings, which are published in the Proceedings of the National Academy of Sciences, suggest that this molecule may aid in diagnosing lung cancer in earlier stages and could potentially, when at healthy levels, aid in treating the disease.

According to the National Cancer Institute (NCI), lung cancer is the leading cause of cancer death among both men and women in the United States, and 90 percent of lung cancer deaths among men and approximately 80 percent of lung cancer deaths among women are due to smoking. The NCI also estimates that approximately 373,489 Americans are living with lung cancer and its treatment costs approximately $10.3 billion in the United States each year.

MicroRNA's are a new class of molecules classified as important regulators of the activity of other genes. In this study, the research team used a next-generation RNA sequencing technology and identified that a microRNA named miR-4423 in epithelial airway cells plays a major role in how these cells develop. In epithelial cells from the airway of smokers with lung cancer, levels of miR-4423 were decreased.

"These results suggest measuring the levels of microRNAs like miR-4423 in cells that line the airway could aid in lung cancer detection through a relatively non-invasive procedure," said Avrum Spira, MD, MSc, the Alexander Graham Bell professor of medicine and chief of the division of computational biomedicine at BUSM, one of the study's senior authors.

Using experimental models in vitro and in vivo, the research team demonstrated that miR-4423 can both promote the
'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... , Sept. 30, 2014  Spectra ... solutions for the biotech and power generation ... new RECONN Bioprocess Manager, an easy-to-use and ... geared towards bioprocess development laboratories. ... disparate bioreactor and analyzer systems. Accessing and ...
(Date:9/30/2014)... People who suffer from asthma may think there,s not ... besides properly taking medications and avoiding allergic triggers. ... Annals of Allergy, Asthma and Immunology , the scientific ... Immunology (ACAAI), asthma sufferers can learn lessons about managing ... in the Annals article improved her asthma once she ...
(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Asthma symptoms kicking up? Check your exposure to air pollution 2Gut bacteria promote obesity in mice 2
... 95 percent genomic similarity to humans, mice have long been ... Once researchers can shine a light on the genetic factors ... prevention and treatment options to protect the human population. ... difficult road, made more challenging by the 5% difference between ...
... shown that a dramatic sea-level rise occurred at the onset ... as the Blling warming, approximately 14,600 years ago. This event, ... rapid collapse of massive ice sheets 14,600 years ago and ... are published in the 29 March 2012 issue of the ...
... The Cardiovascular Cell Therapy Research Network (CCTRN), a ... Health,s (NIH) National Heart, Lung and Blood Institute (NHLBI) ... of its seven U.S. centers of excellence. The network ... over the next seven years to help achieve its ...
Cached Biology News:New lab mice cut search for genetic links to disease by more than a decade 2New lab mice cut search for genetic links to disease by more than a decade 3Ice sheet collapse and sea-level rise at the Boelling warming 14,600 years ago 2Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network 2
(Date:10/1/2014)... , Oct. 1, 2014  Pressure BioSciences, Inc. ... in the development and sale of high pressure-based sample ... announced it has been invited to present at the ... Warsaw , Poland.  The Conference will take ... 2014.  Mr. Richard T. Schumacher , President and ...
(Date:10/1/2014)... 2014  Spherix Incorporated (Nasdaq: SPEX) -- an intellectual property ... of intellectual property, announced today that the Markman ... in the U.S. District Court for the Northern ... been rescheduled for November 10, 2014.  This hearing ... Court Order setting the Markman date was received ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 As the world ... no room for doubt that this century would mark the ... the field of medicine science. The fact that the world ... not unknown to the scientific community. Almost half of these ... therefore can be prevented with medical care and intervention. While ...
(Date:10/1/2014)... La Jolla, Calif. (PRWEB) September 30, 2014 ... (NIH) announced the initial round of grants for ... Initiative, an undertaking that aims to develop and ... neuro circuit functions of the human brain. This ... funding for fiscal year 2014 was allocated to ...
Breaking Biology Technology:Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 2Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 3Pressure BioSciences, Inc. Invited to Present at the 2nd Global Life Sciences Conference in Warsaw, Poland 4Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3
... comes to consumer goods, America is addicted to them. And ... prices, Wal-Mart is the biggest low-price outlet going. We like ... it. , ,The company that many Americans hate to love ... groups have successfully derailed its growth plans in certain parts ...
... the president of an international corporation used to take a ... a PC, strong entrepreneurial spirit, and in less than 30 ... many professionals. It's estimated that 80 percent of businesses fail ... half-full' type, you might be discouraged by such an estimate. ...
... Madison, Wis. - Ann Stunden, chief information officer ... at the University of Wisconsin-Madison, has announced plans to ... helm of campus technology. , ,"We have made some ... I think we have strengthened our relationship with partners ...
Cached Biology Technology:Wal-Mart: How low can you go? 2Wal-Mart: How low can you go? 3Wal-Mart: How low can you go? 430 days to success: Three simple steps to create your own international startup 230 days to success: Three simple steps to create your own international startup 330 days to success: Three simple steps to create your own international startup 430 days to success: Three simple steps to create your own international startup 5Stunden to retire as UW-Madison CIO 2
...
Pronase Reagent...
Rabbit polyclonal to ECSIT ( Abpromise for all tested applications). entrezGeneID: 51295 SwissProtID: Q96HQ7...
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide...
Biology Products: