Navigation Links
BUSM researchers identify key regulator of inflammatory response
Date:4/12/2012

(Boston) Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development of innovative methods to reduce the inflammation associated with cancer, type 2 diabetes and other diseases.

The study, which was led by Valentina Perissi, PhD, assistant professor of biochemistry at BUSM, was done in collaboration with the Howard Hughes Medical Institute (HHMI) at the University of California, San Diego. The results are published online and will be in the April 13 print issue of Molecular Cell.

Cells respond to inflammation by producing cytokines, which are cellular signaling protein molecules that allow for intercellular communication. Cytokines, such as TNF-alpha for example, bind to specific receptors on cellular membranes, activating an intracellular signaling process.

In this study, researchers looked at a gene called GPS2, which was previously known to regulate gene expression in the nucleus. This study found that GPS2 plays a critical role at the cellular membrane level to negatively regulate the signaling cascade activated by TNF-alpha. As a result, they observed that increasing GPS2 levels was sufficient to impair the response to TNF-alpha, resulting in a decreased inflammatory response.

Given this information, the researchers then examined whether having more GPS2 in fat tissue would help reduce the development of insulin resistance in conjunction with obesity. The results were promising as insulin signaling in the fat tissue was greatly improved. However, overexpression of GPS2 in the nucleus also had a negative effect on liver function.

"Our study demonstrates that GPS2 plays an important regulatory function in mitigating inflammation," said Perissi, who served as the study's senior author. "These findings have uncovered a potential new target for therapeutic treatments against diseases such as type 2 diabetes and metabolic syndrome, but more research needs to be done to better understand how GPS2 is regulated and whether we can specifically target its anti-inflammatory role."


'/>"/>
Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. Researchers call for a new direction in oil spill research
2. Researchers identify Achilles heel of dengue virus, target for future vaccines
3. Researchers find critical regulator to tightly control deadly pulmonary fibrosis
4. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
5. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
6. Researchers use game to change how scientists study disease outbreaks
7. Notre Dame researchers using novel method to combat malaria drug resistance
8. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
9. Researchers report potential for a moderate New England red tide in 2012
10. Tales from the crypt lead researchers to cancer discovery
11. Researchers identify new regulator in allergic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Calif. , Jan. 19, 2017 ... enhancing user experience and security for consumer electronics, ... next-generation payment processing systems and cybersecurity solutions, today ... banks, enterprises and financial institutions worldwide to bolster ... of the end-to-end secure user authentication platforms they ...
(Date:1/13/2017)... , Jan. 13, 2017 Sandata ... solutions for the homecare industry, including Electronic Visit ... industry expert, Justin Jugs, as Senior Vice President ... than 15 years of homecare experience to Sandata, ... developing strategic plans to align Sandata,s suite of ...
(Date:1/12/2017)... and PUNE, India , January 12, 2017 ... Forecasts, 2015 - 2022," projects that the global biometric technology market is expected to ... 2016 to 2022. Continue Reading ... ...      ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... ... ... Nipro Corporation (Osaka, Japan) and Transonic Systems Inc. (New York, USA) announced ... and sales rights for all non-OEM Transonic products in Japan. As partners for more ... Nipro - Transonic JV is a natural next step to advance best practices and ...
(Date:1/21/2017)... , Jan. 21, 2017   Boston Biomedical , ... designed to target cancer stemness pathways, today presented data ... napabucasin, at the 2017 American Society of Clinical Oncology ... . In a Phase Ib/II ... designed to inhibit cancer stemness pathways by targeting STAT3 ...
(Date:1/20/2017)... MALDEN, MA (PRWEB) , ... ... ... the leader in Less Exposure Surgery (LES®) Technologies, announced today the next ... the PedFuse Pedicle Screw System platform). In contrast to the competition, SpineFrontier ...
(Date:1/19/2017)... 19, 2017 Research and Markets ... has announced the addition of the ... Forecast to 2025" report to their offering. ... The report provides a detailed analysis on current and future market trends ... using estimated market values as the base numbers Key ...
Breaking Biology Technology: