Navigation Links
BUSM researchers identify key regulator of inflammatory response
Date:4/12/2012

(Boston) Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development of innovative methods to reduce the inflammation associated with cancer, type 2 diabetes and other diseases.

The study, which was led by Valentina Perissi, PhD, assistant professor of biochemistry at BUSM, was done in collaboration with the Howard Hughes Medical Institute (HHMI) at the University of California, San Diego. The results are published online and will be in the April 13 print issue of Molecular Cell.

Cells respond to inflammation by producing cytokines, which are cellular signaling protein molecules that allow for intercellular communication. Cytokines, such as TNF-alpha for example, bind to specific receptors on cellular membranes, activating an intracellular signaling process.

In this study, researchers looked at a gene called GPS2, which was previously known to regulate gene expression in the nucleus. This study found that GPS2 plays a critical role at the cellular membrane level to negatively regulate the signaling cascade activated by TNF-alpha. As a result, they observed that increasing GPS2 levels was sufficient to impair the response to TNF-alpha, resulting in a decreased inflammatory response.

Given this information, the researchers then examined whether having more GPS2 in fat tissue would help reduce the development of insulin resistance in conjunction with obesity. The results were promising as insulin signaling in the fat tissue was greatly improved. However, overexpression of GPS2 in the nucleus also had a negative effect on liver function.

"Our study demonstrates that GPS2 plays an important regulatory function in mitigating inflammation," said Perissi, who served as the study's senior author. "These findings have uncovered a potential new target for therapeutic treatments against diseases such as type 2 diabetes and metabolic syndrome, but more research needs to be done to better understand how GPS2 is regulated and whether we can specifically target its anti-inflammatory role."


'/>"/>
Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. Researchers call for a new direction in oil spill research
2. Researchers identify Achilles heel of dengue virus, target for future vaccines
3. Researchers find critical regulator to tightly control deadly pulmonary fibrosis
4. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
5. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
6. Researchers use game to change how scientists study disease outbreaks
7. Notre Dame researchers using novel method to combat malaria drug resistance
8. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
9. Researchers report potential for a moderate New England red tide in 2012
10. Tales from the crypt lead researchers to cancer discovery
11. Researchers identify new regulator in allergic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces the launch of ... Fatone . Las Vegas , where Joey appeared ... Las Vegas , where Joey appeared at the Wocket ... video ad was filmed at the Consumer Electronics Show (CES2016) in ... to meet and greet fans. --> ...
(Date:1/22/2016)... January 22, 2016 ... addition of the  "Global Behavioral Biometric ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ... Behavioral Biometric Market 2016-2020"  report to ... and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ...
(Date:1/20/2016)... JOSE, Calif. , Jan. 20, 2016 /PRNewswire/ ... developer of human interface solutions, today announced sampling ... controller solution for wearables and small screen applications ... such as printers. Supporting round and rectangular shapes, ... S1423 offers excellent performance with moisture on screen, ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... Novan, Inc. today announced that Director Robert A. Ingram ... In addition, Robert Keegan has been appointed to the ... --> North Carolina . ... of $32.8 million of net proceeds in a private Mezzanine B ... the Research Triangle area of North Carolina . ...
(Date:2/8/2016)... ... February 08, 2016 , ... Bulk food ... bulk foods at various stages of the production process. Despite frequently inspecting loose ... bulk products post packaging such as sacks of dry powders. , Mettler-Toledo Product ...
(Date:2/8/2016)... FLINT, Mich. , Feb. 8, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that ... as a specialty pharmacy resource–user-centric, story-driven, knowledge-based and mobile-friendly. ... ... ... "The ...
(Date:2/5/2016)... 5, 2016 ATCC, the premier global biological ... the medical and life science researchers that are working ...   CDC website . --> ... virus is a single-stranded RNA virus of the Flaviviridae ... Dengue and Chikungunya Viruses. Zika virus is transmitted to ...
Breaking Biology Technology: