Navigation Links
BUSM researchers identify genes that influence hippocampal volume
Date:4/15/2012

ns," said Seshadri.

The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium allowed the researchers to gather data on hippocampal volume from 9,232 people who did not have dementia. They identified four genetic loci, including seven genes in or near these loci that appear to determine hippocampal volume.

The results show that if one of the genes is altered, the hippocampus is, on average, the same size as that of a person four to five years older. These results were replicated in two large European samples that included a mixed-age sample that included some participants with cognitive impairment.

"The findings indicate that these loci may have broad implications for determining the integrity of the hippocampus across a range of ages and cognitive capacities," said Seshadri. One of the genes identified by the researchers was also shown to play a role in memory performance in a different data sample.

The identified genetic associations indicate that certain genes could influence cell death by apoptosis, brain development and neuronal movement during brain development, and oxidative stress. Additionally, the researchers found that the genes play a role in ubiquitination, which is a process by which damaged proteins are removed, whereas other genes code for enzymes targeted by new diabetes medications.

"Future studies need to further explore these genetic regions in order to better understand the role of these genes in determining hippocampal volume," added Seshadri.

One of the largest cohorts involved in the study was the Framingham Heart Study cohort, affiliated with BUSM. Seshadri is a Senior Investigator at the Framingham Heart Study.

"Such important research would not be possible without the ongoing dedication of the Framingham study participants, which now span three generations and six decades," said Seshadri.


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
(Date:4/22/2014)... of Montana,s Wildlife Biology Program, co-wrote a research paper published ... of Sciences on how streamwater chemistry varies across a ... Lowe and co-authors from ... the Cary Institute of Ecosystem Studies, the University of Connecticut ... water samples collected every 10 meters along 32 tributaries of ...
(Date:4/22/2014)... of Massachusetts Amherst and the Instituto Nacional de Pesquisas ... have discovered a new genus and species of electric ... the Amazonia State of Brazil. , Professor Cristina Cox ... Antnio Alves-Gomes of INPA, describe the new bluntnose knifefish ... of the Natural Sciences of Philadelphia . , ...
Breaking Biology News(10 mins):New research focuses on streamwater chemistry, landscape variation 2New electric fish genus and species discovered in Brazil's Rio Negro 2
... University College of Medicine, Hershey, Pennsylvania have discovered that ... receptor (OGFr), which mediates the inhibitory action of opioid ... to understanding the progression and treatment of human ovarian ... were molecularly engineered to have a reduced expression of ...
... An assistant professor at Sam Houston State University, ... the mysteries surrounding the role that genetics and ... "Biosocial research is a multi-disciplinary way of ... involves aspects of behavioral genetics, neuroscience, evolutionary biology ...
... richly illustrated book recounts the passionate personalities and the ... the oldest natural history museum in the Western Hemisphere. ... Sciences of Philadelphia and the Making of American Science ... was founded in Philadelphia in 1812. Early expeditions organized ...
Cached Biology News:A breakthrough in understanding the biology and treatment of ovarian cancer 2A breakthrough in understanding the biology and treatment of ovarian cancer 3Are there biosocial origins for antisocial behavior? 2New book brings to life the making of American science at the Academy of Natural Sciences 2
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled ... 2pm EST (11am PST), “Natural Language Processing: Converting Raw ... technology can turn raw, heterogeneous data into actionable knowledge ... online webinar will last approximately one hour. , Synopsis: ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... Produces Isobutene From... -- EVRY, France, October 6, 2010 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... 6, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Knowing how to build nanosized assemblies of polymers (long ... range of industrial processes, from the production of nanofibers, ... nanoscale circuits and devices. A recent paper in ... polymers in specially engineered confined spaces, opening the door ...
Cached Biology Technology:Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 2Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 3Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 4Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 5Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 6Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 2Elsevier Introduces Article-Based Publishing to Increase Publication Speed 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 4Elsevier Introduces Article-Based Publishing to Increase Publication Speed 5Elsevier Introduces Article-Based Publishing to Increase Publication Speed 6Elsevier Introduces Article-Based Publishing to Increase Publication Speed 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 8Building a smaller, lighter future: Understanding polymer behaviors below 1 nanometer 2
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
... has been developed specifically for the ... on microwell plates/strips. Coating Stabilizer ... the antibody or protein antigen portion ... Product is filtered at 0.2 microns., ...
Biology Products: