Navigation Links
BUSM researchers find potential key to halt progression, reverse damage from emphysema
Date:8/31/2012

(Boston) A study led by researchers at Boston University School of Medicine (BUSM) has shown that a compound used in some skin creams may halt the progression of emphysema and reverse some of the damage caused by the disease. When the compound Gly-His-Lys (GHK) was applied to lung cells from patients with emphysema, normal gene activity in altered cells was restored and damaged aspects of cellular function were repaired.

The study, which is published in BioMed Central's open access journal Genome Medicine, also demonstrates the potential impact of using genomic technologies to identify new possible treatments for diseases using existing drugs and compounds.

Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease that comprises emphysema, small airway obstruction and/or chronic bronchitis leading to the loss of lung function. Tobacco smoke and other irritants cause oxidative stress and chronic inflammation, which over time destroys lung alveolar cells and results in emphysema. Without these cells, the lungs are not able to efficiently exchange oxygen for carbon dioxide, causing shortness of breath and low blood oxygen levels. According to the National Institutes of Health's National Heart, Lung and Blood Institute (NHLBI), COPD is the third leading cause of death in the United States and results in approximately 120,000 deaths each year. While there are treatments and lifestyle changes that can help people cope with COPD, there currently is no cure and there are no effective therapies to reduce the rate of lung function decline that occurs as the disease progresses.

"Given the high costs, both direct and indirect, associated with COPD, there is an urgent need to identify novel approaches to treat the disease," said Avrum Spira, MD, MSc, Alexander Graham Bell professor of medicine and chief of the division of computational biomedicine at BUSM, who was one of the study's senior leaders. Spira also i
'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers launch new Rust-Tracker to monitor deadly wheat fungus in 27 nations
2. University of Tennessee Space Institute researchers make clinical trials a virtual reality
3. New equipment is breath of fresh air for childrens lung researchers
4. Mount Sinai researchers solve mystery surrounding the death of two sisters nearly 50 years ago
5. Stanford researchers discover the anternet
6. By detecting smallest virus, researchers open possibilities for early disease detection
7. Behind closed doors: Researchers show how probiotics boost plant immunity
8. Researchers develop method to grow artificial tissues with embedded nanoscale sensors
9. University of Minnesota engineering researchers discover new non-invasive method for diagnosing epilepsy
10. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
11. U of M researchers: Newly discovered genetic markers could signal colon cancer development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... RENO – Kelly Redmond has dedicated his career ... knowledge to a general audience. , As deputy ... Climate Center at Nevada,s Desert Research Institute, Redmond ... the management, application and dissemination of climate data ... Annual Fall Meeting in San Francisco on December ...
(Date:11/4/2014)... Fla. (November 4, 2014) — Think about the way ... How do neighboring cells know that they are supposed ... how do these tissues find the correct place and ... answering these crucial questions. , In a new study, ... to communicate with their surrounding neighbors, at the head-trunk ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2The inside story: How the brain and skull stay together 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... Fla. -- Leading Florida-based scientific researchers released two new ... that climate change will cause significant impacts on Florida,s ... A second study by researchers at Florida Atlantic University ... of policy programs aimed at adapting to these large ...
... researchers have found that the main source of food for ... appears to adapt in order to survive climate change. ... are just a few millimetres in size, live in the ... out. It showed they responded to global warming after ...
... & Commerce, WALL, N.J., Sept. 23 ... in finger-based biometric,identification and wireless public safety, announced ... Technology Expo, to be held in,conjunction with the ... 25 at the Tampa Convention Center in Tampa, ...
Cached Biology News:New studies find global warming will have significant economic impacts on Florida coasts 2New studies find global warming will have significant economic impacts on Florida coasts 3Researchers find animal with ability to survive climate change 2BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo 2BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo 3
(Date:11/21/2014)... DIEGO , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com on ... 2014 TIME:    11:15 am PT / 2:15 pm ... URL into your browser,s address bar: http://bit.ly/1B2KGaL ... and receive event updates. This will be ...
(Date:11/18/2014)... Cord Blood Registry® (CBR®) announces that ... World Stem Cell Summit, the largest global meeting of stem ... Cell Summit will be held December 3-5 at the Marriott ... The World Stem Cell Summit aims ... therapies, convening the most prominent figures in the field to ...
(Date:11/18/2014)... 17, 2014 Cirrascale Corporation ... blade-based and rackmount computing infrastructure, today announced it ... accelerator throughout its GPU-enabled blade server and high-performance ... company’s latest proprietary 80-lane Gen3 PCIe switch-enabled risers, ... Tesla K80 dual-GPU accelerator cards in a single ...
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – featuring Dr. ... in the Regulatory Biology Laboratory at the Salk Institute, studies ... an “off switch” for drug resistance in cancer. , Learn ... is making a global impact in the fight against cancer. ... Cheryl K. Goodman, CEO of Social Global Mobile LLC, for ...
Breaking Biology Technology:Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3
... May 24, 2012  Novocure™, a commercial stage private oncology ... centers of excellence will join the seven existing clinical ... to patients with recurrent GBM. These fifteen clinical centers ... GBM is both the deadliest and ...
... NEW YORK, May 23, 2012 Exosome Diagnostics, ... for use in personalized and non-invasive cancer diagnostics, ... utility of non-invasive sampling of patients, urine to ... In the first study, the presence of a ...
... imaging system that scans 3D models of historical buildings using ... a human pilot onboard. This is the first 3D imaging ... technologies, and virtual representation of models to produce a realistic ... this project is to obtain a 3D model of a ...
Cached Biology Technology:Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 2Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 3Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 4Exosome Diagnostics Presents Data at American Urology Association Demonstrating Potential Utility of Urine Exosomes to Non-invasively Detect and Manage Prostate Cancer 2Exosome Diagnostics Presents Data at American Urology Association Demonstrating Potential Utility of Urine Exosomes to Non-invasively Detect and Manage Prostate Cancer 3A new imaging system produces 3-D models of monuments using unmanned aircraft 2
... recognizes 30% of IgM-rheumatoid factor ... does not cross-react with IgM, IgA, ... nor with pooled F(Ab)2 fragments. This ... to detect rheumatoid factor. Product Category: ...
...
Salmonella typhimurium Immunogen: Heat inactivated bacterial cells of Salmonella typhimurium B Storage: 4 C...
...
Biology Products: