Navigation Links
BUSM awarded NIH grant to identify role of immune system in chronic inflammation, disease
Date:1/20/2011

(Boston) A team of researchers at Boston University School of Medicine (BUSM) have been awarded a five-year, $7.7 million grant from the National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases (NIAID) to explore how chronic inflammation can lead to systemic diseases. Caroline Genco, PhD, director of research in the section of infectious diseases and professor of medicine and microbiology at BUSM, is the principal investigator on the grant. She will lead a multidisciplinary research team as they study the cellular mechanisms responsible for immune system activation, which induces chronic inflammation following bacterial infection.

Inflammation, which is the body's biological response to infection, initiates the healing process. In most cases, infections with pathogens, including bacteria, result in attack by the immune system and clearance of the pathogen. However, certain types of bacteria persist in the body for long periods of time, causing sub acute chronic infections. During that time, they cause inflammation, which can lead to systemic diseases.

This study focuses on two pathogens, Chlamydophila pneumoniae and Porphyromanas gingivalis, which induce a chronic inflammatory response in the lungs and the mouth, respectively. The chronic inflammation can lead to atherosclerosis, or hardening of the arteries, as a result of plaque buildup.

"The goal of this study is to understand how these pathogens persist and cause inflammation that can eventually lead to disease," said Genco. "The immune system exists to protect us, yet in some circumstances, it has harmful effects and contributes to systemic inflammatory diseases. We are investigating what goes awry in this complex system so that we can identify what mechanisms are responsible for these detrimental health outcomes."

Other researchers at BUSM involved include Robin Ingalls, MD, Frank Gibson, PhD, Guillermo Madico, MD, PhD, and Lee Wetzler, MD, all from the section of infectious diseases; Jane Freedman, MD, and Ellen Weinberg, PhD, of Boston Medical Center's section of cardiology and vascular medicine; James Hamilton, PhD, from the department of physiology & biophysics at BUSM and biomedical engineering at Boston University's College of Engineering; and Michael Lavalley, PhD, of Boston University's School of Public Health.


'/>"/>

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. Nationwide Childrens Hospital awarded $11.5 million contract extension for biospecimen banking
2. Acceleron awarded $1.5 million grant from Muscular Dystrophy Association to support ACE-031
3. Team awarded $7.5 million to identify potential drug candidates to treat nicotine addiction
4. SEBM European Best Poster Prize awarded at Annual Conference of the German Society for Gene Therapy
5. University of Illinois awarded National Science Foundation grant to mentor Latino students
6. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
7. Arjun Deb awarded Louis N. and Arnold M. Katz Basic Science Research Prize
8. New Scripps Florida scientist awarded pair of unconventional grants
9. NIMHs Dr. Mortimer Mishkin to be awarded National Medal of Science
10. Aeras awarded €11.7 million ($16 million) grant from Dutch government
11. Mississauga teacher awarded prize for excellence in teaching genomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... MINNETONKA, Minn. , Jan. 20, 2016   ... that supports the entire spectrum of clinical research, is ... in 2015. MedNet,s significant achievements are the result of ... of) iMedNet eClinical , it,s comprehensive, ... --> --> Key MedNet growth ...
(Date:1/13/2016)... ALBANY, New York , January 13, 2016 /PRNewswire/ ... Transparency Market Research has published a new market report ... Share, Growth, Trends, and Forecast, 2015 - 2023. According to ... mn in 2014 and is anticipated to reach US$1,625.8 ... from 2015 to 2023. In terms of volume, the ...
(Date:1/8/2016)... and MANCHESTER, United Kingdom , ... a developer of innovative sensor-based diagnostic products, today announced the ... by new and existing investors.  Proceeds from the financing will ... Scanner , a hand-held device for detecting early-stage pressure ulcers. ... Ireland after receiving CE Mark approval. The ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016 ContraVir Pharmaceuticals, Inc. ... the development and commercialization of targeted antiviral therapies, announced ... Investor Conference 2016, to be held February 8-9, 2016, ... Group,s 2016 Disruptive Growth & Healthcare Conference, taking place ... 10-11, 2016. James Sapirstein , Chief Executive ...
(Date:2/4/2016)... February 4, 2016 Strasbourg, France ... Inc. --> Strasbourg, France , to ... PharmaVentures is pleased to announce that it acted as ... manufacturing unit in Strasbourg, France , to ... --> --> Transgene (Euronext: TNG), a ...
(Date:2/3/2016)... 3, 2016  With the growing need for ... is underway, therapies such as monoclonal antibodies, recombinant ... host of indications are in high demand. Conventionally ... development and production of these therapeutics. However, due ... high costs, novel approaches and novel expression systems ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, a world-leading supplier of ... North American healthcare market. , Aerocom Healthcare, LLC will be based in Denver, ... provide new pneumatic tube systems or expand existing systems within the U.S. and ...
Breaking Biology Technology: