Navigation Links
BU study finds new genetic loci associated with menopause onset
Date:1/23/2012

(Boston)-- An international team of researchers from the Boston University Schools of Public Health and Medicine and other institutions has uncovered 13 genetic loci, linked to immune function and DNA repair, that are factors in the age of onset of menopause.

Menopause -- the cessation of reproductive function of the ovaries -- is a major hormonal change that affects most women when they are in their early 50s. Most prior studies of the age of onset of menopause have focused on genes from the estrogen-production pathway or vascular components.

In the new study, published online Jan. 22 in Nature Genetics, a research team led by Kathryn Lunetta, professor of biostatistics at the BU School of Public Health, and Joanne Murabito, associate professor of medicine at the BU School of Medicine, identified 13 novel loci associated with menopause onset, while confirming four previously established loci. Most of the 17 loci are associated with genes related to DNA damage repair or auto-immune disease; others are linked to hormonal regulation.

"Our findings demonstrate the role of genes which regulate DNA repair and immune function, as well as genes affecting neuroendocrine pathways of ovarian function in regulating age at menopause, indicating the process of aging is involved in both somatic and germ line aging" the authors said.

Lunetta said the new findings "bring us closer to understanding the genetic basis for the timing of menopause. They may also provide clues to the genetic basis of early onset or premature menopause and reduced fertility.

"We hope that as a better understanding of the biologic effects of these menopause-related variants are uncovered, we will gain new insights into the connections between menopause and cardiovascular disease, breast cancer, osteoporosis, and other traits related to aging, and that this will provide avenues for prevention and treatment of these conditions," she said.


'/>"/>
Contact: Lisa Chedekel
chedekel@bu.edu
617-571-6370
Boston University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Pacific Northwest National Laboratory honored more than ... of intellectual property at PNNL,s annual Intellectual Property ... The Department of Energy national laboratory named materials ... his work developing battery materials that can store ... electrical grid, and reduce the time it takes ...
(Date:5/23/2013)... 284 million tons of cargo, transit the Panama Canal each ... the Panama Canal Authority. Each time a ship passes through, ... Gatun Lake, which is also a source of water for ... However, the advent of very large "super" cargo ships, now ... demanded change. The Panama Canal is being expanded to create ...
(Date:5/23/2013)... Health at Emory University, along with partners at ... $4 million grant over four years to establish ... Exposome Research Center: Understanding Lifetime Exposures). The grant ... the United States. , The HERCULES Center ... Health Sciences (NIEHS) of the National Institutes of ...
Breaking Biology News(10 mins):PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2Reforestation study shows trade-offs between water, carbon and timber 2Reforestation study shows trade-offs between water, carbon and timber 3Emory, Georgia Tech receive first human exposome center grant in US 2Emory, Georgia Tech receive first human exposome center grant in US 3
... CLEMSON, S.C. The environmental engineering and Earth ... $400,000 faculty-development grant from the U.S. Nuclear Regulatory Commission ... nuclear science. Clemson is one of 16 U.S. ... by the NRC to boost nuclear education and expand ...
... have helped settle a long-standing debate about the origin of ... to a new study by University of British Columbia researchers. ... Proceedings of the National Academy of Sciences Early Edition, ... and its role in definitively linking the evolutionary histories of ...
... a gene widely known for precisely positioning and sculpting ... a finding that could be useful for understanding the ... of children are being born with genital and urinary ... Nature Communications , researchers at the University of ...
Cached Biology News:$400,000 NRC grant to develop nuclear engineering faculty at Clemson 2'Little brown balls' tie malaria and algae to common ancestor: UBC research 2Sluggish cell division may help explain genital defects 2Sluggish cell division may help explain genital defects 3Sluggish cell division may help explain genital defects 4
(Date:5/23/2013)... Can economic incentives such as gift ... of the public to increase their donations of blood? ... Carey Business School Assistant Professor Mario Macis says ... large body of recent research that supports their argument, ... issue of Science that the World Health Organization and ...
(Date:5/23/2013)... Yonkers, NY (PRWEB) May 23, 2013 ... GRAPHALLOY® self-lubricating bushings mounted in stainless ... and self-lubricating properties of GRAPHALLOY with the application ... GRAPHALLOY Stainless Steel Pillow Blocks work exceptionally ... other corrosive or hostile liquids such as acids, ...
(Date:5/23/2013)... 2013 Patheon Inc ., a ... the global pharmaceutical industry, will host a complimentary webinar ... Testing” on Tuesday, June 4, 2013 at 11 a.m. ... required to comply with regulations for cleaning validation. ... scientific underpinning and little evaluation of risk. Some ...
(Date:5/23/2013)... , May 23, 2013 PuraMed BioScience ... and marketer of over-the-counter (OTC) medicinal and healthcare ... opinion on the company based on low market ... , Non-Prescription, All Natural Product to Treat Migraine ... Outperforms #1 Prescription Competitor , Currently Available ...
Breaking Biology Technology:Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 2PuraMed BioScience (PMBS) Issued Alert Based on Market Cap of $721,756 3
... Group, Inc., a leading provider of clinical development services ... companies, today announced that more than twenty posters will ... Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition ... N. Morial Convention Center in New Orleans, Louisiana. ...
... Reportlinker.com announces that a new market research ... Building Biotech Technology Transfer Opportunities: ... http://www.reportlinker.com/p0185305/Building-Biotech-Technology-Transfer-Opportunities-Sponsor-and-developer-strategies-for-success.html ... to introduce new products in an environment ...
... 4, 2010 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, announced today that the Company ... the Qualifying Therapeutic Discovery Project, enacted as part of ... (P.L. 111-148). The grant is a benefit targeted to ...
Cached Biology Technology:PharmaNet to Present More Than 20 Posters at the 2010 American Association of Pharmaceutical Scientists Annual Meeting 2PharmaNet to Present More Than 20 Posters at the 2010 American Association of Pharmaceutical Scientists Annual Meeting 3Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 2Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 3Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 4Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 5Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 6Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success 7PharmAthene Receives Four Therapeutic Discovery Project Grants Totaling Approximately $850,000 2PharmAthene Receives Four Therapeutic Discovery Project Grants Totaling Approximately $850,000 3
... provides valuable walk-away time and relief from ... technology for parallel processing of stacking and ... automation for any laboratory in need of ... can be set-up within minutes to most ...
The Wellwash 4 Mk 2 combines high performance and flexibility with reliability, simplicity and ease of use. This advanced microplate washer meets the exacting standards of today's assay requirements....
Recombinant Rhesus Monkey IFN Alpha Activity: 2.9 x 10 8 u/mg...
... These handy dispensers save space ... hats, and other garb. They are ... small parts used in labs, processing ... static charges and the particles they ...
Biology Products: