Navigation Links
BU study finds new genetic loci associated with menopause onset
Date:1/23/2012

(Boston)-- An international team of researchers from the Boston University Schools of Public Health and Medicine and other institutions has uncovered 13 genetic loci, linked to immune function and DNA repair, that are factors in the age of onset of menopause.

Menopause -- the cessation of reproductive function of the ovaries -- is a major hormonal change that affects most women when they are in their early 50s. Most prior studies of the age of onset of menopause have focused on genes from the estrogen-production pathway or vascular components.

In the new study, published online Jan. 22 in Nature Genetics, a research team led by Kathryn Lunetta, professor of biostatistics at the BU School of Public Health, and Joanne Murabito, associate professor of medicine at the BU School of Medicine, identified 13 novel loci associated with menopause onset, while confirming four previously established loci. Most of the 17 loci are associated with genes related to DNA damage repair or auto-immune disease; others are linked to hormonal regulation.

"Our findings demonstrate the role of genes which regulate DNA repair and immune function, as well as genes affecting neuroendocrine pathways of ovarian function in regulating age at menopause, indicating the process of aging is involved in both somatic and germ line aging" the authors said.

Lunetta said the new findings "bring us closer to understanding the genetic basis for the timing of menopause. They may also provide clues to the genetic basis of early onset or premature menopause and reduced fertility.

"We hope that as a better understanding of the biologic effects of these menopause-related variants are uncovered, we will gain new insights into the connections between menopause and cardiovascular disease, breast cancer, osteoporosis, and other traits related to aging, and that this will provide avenues for prevention and treatment of these conditions," she said.


'/>"/>
Contact: Lisa Chedekel
chedekel@bu.edu
617-571-6370
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ... technology is accurate, flexible and robust – with the ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today ... its School of Medicine. Funding for this $50 million ... that will be publicly launched next summer. ... the former 60 series R.J. Reynolds Tobacco Company complex, ... will begin immediately with plans to be ready to ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... The first-ever drug known to prevent some preterm births, which won ... by the March of Dimes. "For the first time, we ... baby too soon, giving them hope that their next child will ... Alan Fleischman, MD, senior vice president and medical director of the ...
... not always what they seem when it comes to fishsomething ... are finding out. Using modern genetic analysis, combined with traditional ... thought to be three species of blenny in the genus ... findings are published in the scientific journal ZooKeys , ...
... hunt by Johns Hopkins scientists for actively "jumping genes" in ... but static, contains numerous pesky mobile elements that may help ... traits and disease risks. Using bioinformatics to ... the reference human genome to raw whole-genome data from 310 ...
Cached Biology News:March of Dimes welcomes FDA approval of progesterone injections 2Smithsonian scientists discover 7 new species of fish 2Johns Hopkins researchers capture jumping genes 2
(Date:12/17/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) ... changes to Martine Rothblatt , Ph.D,s compensation program. ... United Therapeutics announced the promotion of Roger Jeffs ... David Zaccardelli , Pharm.D. to Executive Vice President ... Dr. Rothblatt,s title will change from Chairman and Chief ...
(Date:12/15/2014)... NEW YORK & PETACH TIKVAH, ... Therapeutics Inc. (NASDAQ: BCLI ), a leading ... announced today that wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. ... Israel,s Office of the Chief ... has been in receipt of grant support from the ...
(Date:12/13/2014)... CanDiag, Inc., a University of North Carolina at ... to OncoTab, Inc. , “The new name is ... said CEO and Chief Science Officer, Dr. Pinku Mukherjee, ... diagnostics to include imaging and therapies, and our new ... in 2011 by Dr. Mukherjee, an Irwin Belk Endowed ...
(Date:12/13/2014)... (PRWEB) December 13, 2014 The ... the major market drivers, threats, opportunities, and challenges. ... by three major players, namely, Thermo Fisher Scientific, ... (Netherlands). These players jointly accounted for approximately ~65% ... , Full Copy for This Report @ ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 3
... Dynatronics,Corporation (Nasdaq: DYNT ) will release ... June 30, 2007 during the morning of Friday, ... call for investors later that,day at 1:00 p.m. ... and fiscal year.,Those interested in participating should call ...
... Leadership in Clean Technology and Global Business Potential, ... Solazyme, Inc., a,leading algal biotechnology company, today announced ... of the GoingGreen 100 Top Private Companies for,2007. ... by the,AlwaysOn editorial panel. In order to be ...
... ACCESS PHARMACEUTICALS, INC.,(OTC Bulletin Board: ACCP) announced ... BusinessWeek, highlighted Access Pharmaceuticals in the,most recent ... is also available,on http://www.BusinessWeek.com under ... article focused upon the major opportunity Access, ...
Cached Biology Technology:Solazyme, Inc. Selected by AlwaysOn as a GoingGreen 100 Top Private Company Award Winner 2Solazyme, Inc. Selected by AlwaysOn as a GoingGreen 100 Top Private Company Award Winner 3Access Highlighted in Recent BusinessWeek Article 2
... The Zero Blunt ... offers the fastest and ... (greater than or equal ... PCR products amplified with ...
Blot Paper 7 x 8.5cm semi-dry western blots (order number RB-400)...
... Create 100% capped transcripts with the ... higher yields of 100% capped (versus 40% ... mRNA messages in about 2 hours. mScript™ ... has been shown to be up to ...
Immunogen: Synthetic peptide: M(1) C V P R S G L I L S(11) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: