Navigation Links
BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
Date:4/5/2012

cell and these progenitors could be purified using the fluorescent tag that glowed only once the cells had become lung or thyroid cells.

"We succeeded in capturing a cell fate decision in cultured stem cells that is normally very transient during the earliest stages of lung and thyroid development," said Kotton, who also is an associate professor of medicine at BUSM. "Most importantly, our results emphasize that the precise inhibition of certain pathways at defined stages is as important as the addition of pathway stimulators at different developmental stages during lung and thyroid specification."

To demonstrate that the cells purified by the investigators were lung progenitors, Kotton's team studied the global gene expression profiles of the cells they derived and placed the cells into a three-dimensional lung scaffold. The cells grew and multiplied, forming two types of lung cells that normally coat the air sacs of the lungs.

The findings indicate that this technology can be used to grow new primordial lung progenitors to study human disease in vitro, which could lead to novel therapies to treat patients with end stage lung disease, such as emphysema and Cystic Fibrosis.

"The ability to generate a supply of progenitor cells with the potential to differentiate into lung cells will be a huge boon to several research fields," said James Kiley, PhD, director of the Division of Lung Diseases at the National Heart, Lung, and Blood Institute (NHLBI), which funded the study. "It lays the groundwork for studying the mechanisms and programming of cells during lung development, which, in turn, will help develop new treatments."


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers report potential for a moderate New England red tide in 2012
2. Tales from the crypt lead researchers to cancer discovery
3. Researchers identify new regulator in allergic diseases
4. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
5. Researchers unravel genetic mechanism of fatty liver disease in obese children
6. Montreal researchers repel mortality in Malian mothers
7. UF researchers look for ways to make an emerging technology safe for environment
8. UCSB researchers to examine the effects of year-old NOAA West Coast Catch Shares program
9. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
10. Researchers discover novel therapy for Crohns disease
11. Researchers reveal how a single gene mutation leads to uncontrolled obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... YORK , Dec. 15, 2014  HITLAB ... Good Clinical Practices (GCP) audit to confirm its ... (FDA) regulations. This accomplishment enables HITLAB to conduct ... utilizing the highest principles for patient safety and ... improve global healthcare access, quality, and delivery with ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... an entrepreneur begins early for students at Wake ... so excited about their first-year seminar in biophysics ... three-phase business plan, they are raising start-up funds ... BioBotz, which aims to produce an educational interactive ...
... Energy lost from hot engines could save ... and converted into electricity via thermoelectric devices, Clemson ... Dallas for the world-renowned NanoTX 07 conference. ... Memorial Nano Energy Summit on challenges in alternative ...
... When someone feigns sadness they cry crocodile tears, ... the animals cry while eating. Now, a University ... bawl while banqueting but for physiological reasons rather ... observed and videotaped four captive caimans and three alligators, ...
Cached Biology News:Freshman class sparks start-up company 2Clemson physicist addresses international forum on thermoelectric energy 2Researchers: No faking it, crocodile tears are real 2
(Date:12/15/2014)... 15, 2014  Ascendis Pharma A/S, a biotechnology ... address significant unmet medical needs, today announced positive ... pediatric study to evaluate once-weekly TransCon Growth Hormone ... This interim analysis consists of 25 patients, representing ... the study, completing all six months of treatment. ...
(Date:12/13/2014)... and TAICHUNG, Taiwan (PRWEB) December 12, 2014 ... less rosy indicators in overall global economic growth, Eugene ... optics and photonics , said in a featured talk ... on 5 December at the National Chung Hsing University ... which is being integrated into future energy supplies and ...
(Date:12/13/2014)... , Dec. 11, 2014 Research and ... the addition of the "Glucose Sensors: the ... http://photos.prnewswire.com/prnh/20130307/600769 ... product designs is giving hope for a better ... glucose monitors that can measure glucose levels accurately ...
(Date:12/12/2014)... Pittsburgh, PA (PRWEB) December 11, 2014 ... 2015 Technical Program that includes over 2,000 ... awards, and posters. This year’s program covers ... not limited to, biotechnology, biomedical, drug discovery, environmental, ... nanotechnology, polymers/plastics, proteomics and water/wastewater. The Technical ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Glucose Sensors: the Next Generation 2Glucose Sensors: the Next Generation 3Pittcon Announces a Diverse 2015 Technical Program - Renowned Speakers, Special Symposia and Co-programming 2Pittcon Announces a Diverse 2015 Technical Program - Renowned Speakers, Special Symposia and Co-programming 3
... July 24 Human Genome,Sciences, Inc. (Nasdaq: ... has,been appointed to the HGS Board of Directors. ... Company,s Audit Committee. Until recently, Mr. Southwell was,at ... served,as Executive Vice President and Chief Financial Officer, ...
... overcome a major obstacle in producing transistors from networks ... possible to print circuits on plastic sheets for applications ... an entire aircraft to monitor crack formation. , The ... nanotubes randomly overlapping in a fishnet-like structure - has ...
... eResearchTechnology,Inc. (eRT or the Company), (Nasdaq: ERES ... technology, ePRO and other services to the,pharmaceutical, biotechnology, ... of Mr. Keith D. Schneck as Executive Vice,President ... Mr. Schneck joins eRT with over 30 ...
Cached Biology Technology:Human Genome Sciences Appoints David P. Southwell to its Board of Directors 2Human Genome Sciences Appoints David P. Southwell to its Board of Directors 3Human Genome Sciences Appoints David P. Southwell to its Board of Directors 4'Nanonet' circuits closer to making flexible electronics reality 2'Nanonet' circuits closer to making flexible electronics reality 3'Nanonet' circuits closer to making flexible electronics reality 4eResearchTechnology Names New Chief Financial Officer 2eResearchTechnology Names New Chief Financial Officer 3
... enable rapid analytical to medium scale affinity ... appropriate vectors. Sufficient reagents are provided for ... protein under native or denaturing conditions. Crude ... specifically retains STag fusion proteins. After unbound ...
... STag Purification Kits enable rapid analytical to ... proteins produced from appropriate vectors. Sufficient reagents ... 1 mg target protein under native or ... S-protein Agarose, which specifically retains STag fusion ...
High affinity antibody reacting with S-100 ab heterodimer. Could be used for Western blotting application and immunoassay....
Useful for determination of glucose and ATP. Packaging: Package sizes are based on hexokinase units. Preparation Unit Definition: One unit will phosphorylate 1.0 mol of D -glucose per min at pH ...
Biology Products: