Navigation Links
BRG1 mutations confer resistance to hormones in lung cancer

Retinoic acid (vitamin A) and steroids are hormones found in our body that protect against oxidative stress, reduce inflammation and are involved in cellular differentiation processes. One of the characteristics of tumours is that their cells have lost the ability to differentiate; therefore these hormones have useful properties to prevent cancer. Currently, retinoic acid and steroids are being used to treat some types of leukaemia.

A study led by the research group on Genes and Cancer of the Bellvitge Biomedical Research Institute (IDIBELL) has shown that the loss of BRG1 gene implies a lack of response of cells to these hormones, and therefore the tumour may continue growing. Study results have been published in the journal EMBO Molecular Medicine.

BRG1 gene

The IDIBELL research group on Genes and Cancer led by Montse Sanchez-Cespedes discovered some years ago that the BRG1 gene, a tumour suppressor, is inactivated in non-small cell lung cancer by genetic mutations. "The BRG1 protein is part of a chromatin remodelling complex that regulates the expression of several genes", explains the researcher, "and it is related to the differentiation of lung cells, allowing cells response to certain hormones and environment vitamins like vitamin A or steroids."

When BRG1 is mutated and therefore inactive, tumour cells do not respond to the presence of these hormones and they continue growing and spreading. For this reason, these types of tumours are refractory to the treatment with these substances.

Clinic Application

"At the moment", says Montse Sanchez-Cespedes, "we are not able to restore the functionality of a tumour suppressor gene as BRG1 in patients. Therefore, we are still far from a therapeutic application but this discovery enables us to understand better the biology of tumours. What we will try to do in the immediate future is to look for agents that specifically destroy the cells with mutated BRG1, following the strategy of lethal synthetics".

In any case, this finding it can be useful in advancing personalized medicine, because "it explains why lung cancer patients are resistant to these treatments and may serve to rule out therapies with lipid-derived hormones in patients with BRG1 mutations, not just in lung cancer but also in breast and prostate, among others."


Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Related biology news :

1. Researchers discover gene mutations that cause childhood brain cancer
2. Penn biologists discover how silent mutations influence protein production
3. Rapid approach to identify influenza A virus mutations and drug resistance developed
4. Further gene mutations linked to autism risk
5. DNA mutations linked to diabetes
6. Species diversity helps ASU researchers refine analyses of human gene mutations
7. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
8. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
9. Mutations in different cells cooperate to set the stage for cancer
10. Supplement blocks the initiation of breast cell mutations by estrogens
11. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
Post Your Comments:
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:3/30/2017)... , March 30, 2017 The research ... system for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D ... a new realm of speed and accuracy for use in identification, ... an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/10/2017)... SANTA CRUZ, Calif. , Oct. 10, 2017 /PRNewswire/ ... SBIR grant from the NIH to develop RealSeq®-SC (Single ... preparation kit for profiling small RNAs (including microRNAs) from ... Cell Analysis Program highlights the need to accelerate development ... "New techniques for ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
Breaking Biology Technology: