Navigation Links
BPA linked to potential adverse effects on heart and kidneys
Date:1/9/2013

NEW YORK (January 9, 2013) Exposure to a chemical once used widely in plastic bottles and still found in aluminum cans appears to be associated with a biomarker for higher risk of heart and kidney disease in children and adolescents, according to an analysis of national survey data by NYU School of Medicine researchers published in the January 9, 2013, online issue of Kidney International, a Nature publication.

Laboratory studies suggest that even low levels of bisphenol A (BPA) like the ones identified in this national survey of children and adolescents increase oxidative stress and inflammation that promotes protein leakage into the urine, which is a biomarker for early renal impairment and future risk of developing coronary heart disease, according to Leonardo Trasande, MD, MPP, associate professor of pediatrics, environmental medicine, and population health, and co-lead author of the study.

The study adds to the growing concerns about BPA, which was recently banned by the U.S. Food and Drug Administration but is still used as an internal coating for aluminum cans. Manufacturers say the chemical provides an antiseptic function, but studies have shown the chemical disrupts multiple mechanisms of human metabolism.

"While our cross-sectional study cannot definitively confirm that BPA contributes to heart disease or kidney dysfunction in children, together with our previous study of BPA and obesity, this new data adds to already existing concerns about BPA as a contributor to cardiovascular risk in children and adolescents," says Dr. Trasande. "It further supports the call to limit exposure of BPA in this country, especially in children," he says. "Removing it from aluminum cans is probably one of the best ways we can limit exposure. There are alternatives that manufacturers can use to line aluminum cans."

Children in the United States are exposed to the chemical early in life and surveys have shown that by age six nearly 92 percent of children have some trace of BPA in their urine. Its use has been banned in the European Union and Canada, and in the United States for use in baby bottles and sippy cups. Last September Dr. Trasande's group published a study showing a significant association between obesity and children and adolescents with higher concentrations of BPA in their urine in the Journal of the American Medical Association.

In the new study Dr. Trasande, Teresa Attina, MD, PhD, MPH, and Howard Trachtman, MD, of NYU School of Medicine's Department of Pediatrics, analyzed data on 710 children and adolescents aged 6 to 19 collected in a national survey to assess the health and nutritional status of adults and children in the United States. The data was from the 2009-2010 National Health and Nutrition Examination Survey (NHANES), which contained measurements on urinary BPA, and a protein called albumin, which is not normally found in urine because the spaces in the glomerular membrane of the kidney are too small to allow protein molecules to escape. If there is membrane damage as in some kidney diseases like glomerulonephritis, albumin can leak through into the urine.

The researchers controlled for risk factors such as hypertension, insulin resistance, elevated cholesterol, exposure to tobacco smoke, race/ethnicity, caregiver education, poverty to income ratio, age, weight and gender in these children. Children with the highest amount of BPA in their urine, compared to those with the lowest amount, had a higher albumin to creatinine ratio, a potential early marker of renal impairment and future risk of developing coronary heart disease, according to the study.

"While we excluded children with pre-existing kidney disease from our analysis, I am concerned that BPA exposure may have even greater effects on children with kidney disease," says Dr. Trachtman, co-lead author of the study. "Because their kidneys are already working harder to compensate and have limited functional reserve, they may be more susceptible to the adverse effects of environmental toxins. We clearly need further study of BPA exposure and its effects on the kidney both in healthy children and in children who have pre-existing kidney disease."

The researchers concluded their analysis by emphasizing the need for further research on environmental chemicals and cardiovascular disease, noting that further study may well transform our understanding "from one that focuses on dietary risks to an approach that recognizes the role of environmental chemical factors that may independently impart the risk of future cardiovascular disease."


'/>"/>

Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Related biology news :

1. Dopamine-receptor gene variant linked to human longevity
2. Bullying by childhood peers leaves a trace that can change the expression of a gene linked to mood
3. Abuse during childhood linked to adult-onset asthma in African-American women
4. Gene linked to respiratory distress in babies
5. Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds
6. Lack of nutrients and metabolic syndrome linked to different subtypes of depression
7. Estrogenic plants linked to altered hormones, possible behavior changes in monkeys
8. Uranium exposure linked to increased lupus rate
9. Gene variations linked to lung cancer susceptibility in Asian women
10. USF researchers identify gene mutation linked to old age hearing loss
11. Sinusitis linked to microbial diversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... DUBLIN , June 27, 2016 Research ... in North America 2016-2020" report to their offering. ... North America to grow at a CAGR ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight Medical ... to the healthcare market. The company's primary focus is on new product introductions, ... strategies that are necessary to help companies efficiently bring their products to market. ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
Breaking Biology Technology: