Navigation Links
BMC awarded NIH grant to study brain abnormalities in former ELGANS patients
Date:9/9/2011

(Boston) Researchers and clinicians from Boston Medical Center (BMC) have been awarded a four year, more than $13 million grant from the National Institutes of Health (NIH) to study neurological and brain abnormalities in former extremely low gestational age newborns (ELGANS). The study will be conducted under the direction of Karl Kuban, MD, chief of pediatric neurology at BMC, who also is the principal investigator of the study. BMC is the lead institution among 14 collaborating organizations across the country participating in this study.

The study, which is scheduled to begin later this month, will build on the ELGAN-1 prospective study of nearly a thousand ELGANs who were evaluated following birth and again at 2 years of age. Of those, 11 percent had cerebral palsy, 40 percent had a developmental quotient below 70, and 11 percent had microcephaly.

As part of the ELGAN-1 study, placenta organisms and histologic characteristics and elevated blood concentrations of proteins during the first postnatal weeks predicted 2-year cognitive and motor impairments and microcephaly. Additionally, 21 percent screened positive for autism spectrum disorders at 2 years.

"Our primary hypothesis is that at 10 years, former ELGANs who had elevated blood concentrations of inflammation-associated biomarkers in the first 2 postnatal weeks are more likely than other former ELGANs to have cognitive, behavioral and neurological disorders and brain structural abnormalities," explained Kuban who also is professor of pediatrics and neurology at Boston University School of Medicine. Ten years was chosen as an age when early adverse neurological problems often manifest with long-term and identifiable educational and quality of life consequences.

The Elgan-2 study will evaluate nearly 1,000 10 year-old ELGAN-1 participants at a dozen institutions in North Carolina, New England and the Midwest. Evaluations will entail direct participant testing and questionnaire/interview activities with the parent/guardian. About 20 percent of the cohort will return on a separate day for an added evaluation for autism (ADOS), and 20 percent will return on a separate day for a brain MRI study.

"In addition to supporting a potential role for many previously identified antecedents of brain damage in ELGANs, our previous study was the first to provide strong evidence that brain damage in extremely preterm infants is associated with microorganisms in placenta parenchyma. We hope to add to those findings thanks to the generosity of this NIH grant," Kuban said.

"We anticipate that this work will help establish a method for identifying infants at high risk as targets for clinical trials of prophylactic and therapeutic interventions. Ultimately, we hope that the result of our work will broaden and redirect the rationale for preventive and therapeutic interventions intended to reduce the risk and severity of neurodevelopmental disorders in ELGANs," added Kuban.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. Louisville researcher awarded $12.8 million NIH grant renewal for adult stem cell project
2. Mass. Eye and Ear awarded largest NIH grant in hospital’s history
3. Young investigators awarded for research excellence at Australia meeting
4. Wayne State start-up company NextCAT awarded nearly $500,000 from NSF for Phase II SBIR
5. Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research
6. BUSM professor awarded $13.3 million to study potential treatments to prevent STDs
7. Lincoln Park Zoo awarded 2 significant grants for science education
8. BUSM awarded $9 million to investigate treatment for sickle cell disease using iPS cells
9. Grants awarded to help bring promising bioscience discoveries to market
10. Johns Hopkins researchers awarded $32 million
11. UTMB-led researchers awarded $7.8 million for Gulf spill study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... India , March 11, 2016 ... a new market research report "Image Recognition Market by ... Application (Marketing and Advertising), by Deployment Type (On-Premises and ... Forecast To 2022", published by MarketsandMarkets, the global market ... 2015 to USD 29.98 Billion by 2020, at a ...
(Date:3/9/2016)... March 9, 2016 This BCC Research report ... of the RNA Sequencing (RNA Seq) market for the ... instruments, tools and reagents, data analysis, and services. ... of the RNA-Sequencing market such as RNA-Sequencing tools and ... main factors affecting each segment and forecast their market ...
(Date:3/8/2016)... , March 8, 2016   Valencell , ... today announced it has secured $11M in Series ... Tech, a new venture fund being launched by ... participation from existing investors TDF Ventures and WSJ ... to continue its triple-digit growth and accelerate its ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... -- There is no saying when exactly ... pressures in pricing and lack in consumer confidence. One ... - numerous opportunities are up for grabs but this ... four names in this sector: Portola Pharmaceuticals Inc. (NASDAQ: ... VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
(Date:5/18/2016)... (PRWEB) , ... May 18, 2016 , ... Tech ... the Luis Villalobos Award to Cognition Therapeutics at the annual ACA Summit last week ... that is financed by one of ACA’s member angel groups. It is the highest ...
(Date:5/18/2016)... Washington, PA (PRWEB) , ... May 18, 2016 ... ... at least 1,200 hospitalizations are a direct result of asthma complications.* Costing more ... challenge across the country. , “For too many, the suffering ...
(Date:5/17/2016)... ... May 17, 2016 , ... DryLet, LLC, a biotechnology company ... it will be showcasing ManureMagic™ at booth V1061 at the World Pork Expo, ... Street Journal last year and more recently made news as the results were ...
Breaking Biology Technology: