Navigation Links
BIDMC scientist David J. Friedman, M.D., receives award from Doris Duke Charitable Foundation

BOSTON David J. Friedman, MD, a clinician and scientific investigator in the Division of Nephrology and Center for Vascular Biology Research at Beth Israel Deaconess Medical Center (BIDMC) has been selected to receive a Clinical Scientist Development Award (CSDA) from the Doris Duke Charitable Foundation. The three-year award, which totals $486,000, will support Friedman's research into the genetic and environmental factors that lead to kidney disease in African Americans, in particular the role of a gene called APOL1.

"As investigators, physician-scientists face a particularly large challenge: meeting both the demands of seeing patients and conducting research," said Betsy Myers, Director of the Medical Research Program for the Doris Duke Charitable Foundation. "Supporting the work of promising investigators while they're still early in their careers remains critical to keeping the clinical research workforce strong."

A graduate of Harvard College, Friedman received his medical degree from the Yale School of Medicine and went on to complete his residency at BIDMC. From 2003 to 2005 he was a Clinical Fellow in BIDMC's Division of Nephrology and from 2004 to 2007 was a Research Fellow in the Division of Nephrology. An Assistant Professor of Medicine at Harvard Medical School (HMS), Friedman is the recipient of numerous HMS teaching awards.

"Dr. Friedman's important work may one day translate into new diagnostic tools and therapeutic strategies to help prevent end-stage renal disease," explains BIDMC Chief of Nephrology Martin Pollak, MD. Last year Pollak and Friedman co-authored a paper in the journal Science that identified two common coding variants in the APOL1 gene on chromosome 22 which greatly increase the risk of end-stage renal disease in African Americans. "This devastating and costly condition affects nearly 500,000 people in the United States, and is four to five times more common in African Americans compared to Caucasian Americans. Clearly, new diagnostic and treatment options are needed," adds Pollak.

Furthermore, says Friedman, as many as 3.5 million African Americans likely have the high risk APOL1 genotype.

"This gene increases a person's risk of developing kidney failure approximately 10-fold," he explains. "Investigating this gene is particularly challenging because only humans and a few primate species have the APOL1 gene in their genomes. Studies in patients with the disease are essential, and with this support from the Doris Duke Charitable Foundation, we hope to develop a better understanding of the genetic and environmental influences that modify the major APOL1 risk alleles."


Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Related biology news :

1. BIDMC scientist John Rinn, Ph.D., receives Damon-Runyon Rachleff Innovation Award
2. Cutting-edge imaging techniques for neuroscientists available in latest laboratory manual
3. New duck-billed dinosaur gives scientists clues to evolution of head ornamentation and provinciality
4. Scripps Research scientists create vaccine against heroin high
5. Hebrew U. scientists show for first time how early human embryo acquires its shape
6. Plenary speakers address challenges in the delivery of sustained antiretroviral therapy in developing countries, call for social scientists to take their place at the HIV/AIDS policy-making table, and stress the need for a long-term response to AIDS
7. OHSU scientists discover new role for vitamin C in the eye -- and the brain
8. Scientists to assemble knowledgebase on plants, microbes, to aid US biofuel, environment efforts
9. BUSM professor selected as American Heart Association Distinguished Scientist
10. Simple little spud helps scientists crack potatos mighty genome
11. Scientists discover first gonorrhea strain resistant to all available antibiotics
Post Your Comments:
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: ) ... customers enhanced security to access and transact across ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, ... of the Supplyframe Design Lab . Located in Pasadena, Calif., the Design ... of how hardware projects are designed, built and brought to market. , The ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory ... technical consulting, provides a free webinar on Performing Quality Investigations: Getting ... at 12pm CT at no charge. , Incomplete investigations are still a major ...
(Date:6/22/2016)... June 22, 2016 Cell Applications, Inc. ... them to produce up to one billion human ... within one week. These high-quality, consistent stem cells ... cells and spend more time doing meaningful, relevant ... proprietary, high-volume manufacturing process that produces affordable, reliable ...
Breaking Biology Technology: