BOSTON A cardiovascular research team from Beth Israel Deaconess Medical Center (BIDMC) and Brigham and Women's Hospital (BWH), led by BIDMC Principal Investigator Saumya Das, MD, PhD, has been awarded a $4 million Common Fund grant from the National Institutes of Health (NIH) as part of a newly formed program on Extracellular RNA Communication. The five-year grant will focus on identifying microRNA biomarkers in heart disease.
Each year, complications from heart attacks (myocardial infarctions) contribute to more than half a million cases of heart failure and 300,000 cases of sudden cardiac arrest, when the heart suddenly stops. Both of these conditions are closely related to a process known as remodeling, in which the structure and function of the heart changes or remodels -- following a heart attack.
"Our goal is to explore the role that microRNAs play in predicting which heart-attack patients will go on to experience complications," explains Das, an electrophysiologist in BIDMC's Cardiovascular Institute and co-director of the cardiovascular genetics program within the Outpatient Cardiovascular Clinic.
"Current strategies used to identify the highest risk patients have often been inaccurate," he adds. "We think that a blood test that makes use of microRNA biomarkers could replace existing strategies and more accurately predict which patients might experience poor outcomes and thereby identify who would most benefit from frequent monitoring and medical care." Other investigators who are part of the NIH grant, "Plasma miRNA Predictors of Adverse Mechanical and Electrical Remodeling After Myocardial Infarction," include BIDMC Director of Cardiovascular Research Anthony Rosenzweig, MD, and BWH investigators Raymond Y. Kwong, MD, MPH, and Mark Sabatine, MD, MPH.
microRNAs are one type of extracellular RNA. Once considered nothing more than genomic "junk," microRNAs have more recently been recognized as playing a key rol
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Beth Israel Deaconess Medical Center