Navigation Links
BGI presents a high-quality gene catalog of human gut microbiome
Date:7/7/2014

July 7, 2014, Shenzhen, China Researchers from BGI, working within the Metagenomics of the Human Intestinal Tract (MetaHIT) project, and in collaboration with other institutions around the world , have established the highest quality integrated gene set for the human gut microbiome to date- a close-to-complete catalogue of the microbes that reside inside us and massively outnumber our own cells. While the roughly 20,000 genes in the human genome have been available for over a decade, the gene catalog of the microbiome, our much larger "other genome", has to date been much more poorly understood and characterized.

The data released from this study should facilitate further research on the interactions between human and microbial genomes, and brings us closer to an understanding of how to maintain the microbial balance that keeps us healthy. The latest study was published online today in the journal Nature Biotechnology.

Each of our guts is colonized by more than 3 pounds of microorganisms that can break down toxins, manufacture vitamins and essential amino acids, and form a barrier against invaders. However, until now there has been a lack of comprehensive and uniformly processed database resources cataloging the human gut microbiota around the world, which has hindered our knowledge of the genetic and functional mechanism of human gut microbes.

In this study, researchers established a catalog of the human gut microbial genes by processing 249 newly sequenced samples and 1,018 published samples from MetaHIT, Human Microbiome Project (HMP) and a large diabetes study from China, as well as 511 sequenced genomes of gut-related bacteria and archaea. This expanded research is at least three times larger than the cohorts used for previous gene catalogs.

Based upon the catalog, researchers investigated the gut microbiota of healthy Chinese and Danish adults, and found the two cohorts greatly differed in nutrient metabolism as well as xenobiotic detoxification, which might be influenced by the differences in diet and environment. In addition, they observed enrichment in possible antibiotic resistance genes both at the population level (penicillin resistance in Danes and multidrug resistance in Chinese) and in the individual-specific genes, which highlighted the need for close monitoring of direct and indirect exposure to antibiotics.

Individual-specific genes contributed overwhelmingly to the increased total gene number in the integrated gene catalog and were overrepresented in genes responsible for the synthesis of cell wall components, DNA-related functions such as transposases, endonucleases and DNA methylases and encoding phage-related proteins. Such individual-specific genes likely reflect adaptation and might reflect the distinct combination of genetic, nutritional and medical factors in a host.

This nonredundant reference catalog of over 9.8 million genes is freely accessible through the website and the data have also been deposited in BGI's GigaScience Database, GigaDB and the SRA. It provides a much expanded and invaluable resource for global researchers to more deeply explore the geographical, genetic, temporal and physiological characteristics of gut microbes.

Junhua Li, Research Scientist from BGI, said, "Catalogs of reference genes in the human gut microbiome should facilitate quantitative characterization of multi-omic data from the gut microbiome to understand its variation across populations in human health and disease."


'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Related biology news :

1. Report presents designs for study of cancer risks near US nuclear facilities
2. NYU School of Medicine presents 2012 Dart/NYU Biotechnology Achievement Awards
3. John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting
4. GSA Bulletin presents studies in Antarctica, Italy, Mexico, Algeria, Mongolia, and more
5. Crop Science Society of America presents 2012 class of fellows
6. IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management
7. Choline supplementation during pregnancy presents a new approach to schizophrenia prevention
8. July meeting presents animal and dairy science
9. Ludwig presents advancements in immunotherapy and epigenetics at the American Association for Cancer Research Annual Meeting
10. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
11. Yin-yang effect of sodium and chloride presents salt conundrum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/4/2019)... , ... June 04, 2019 , ... ... announced the appointment of Susan Murphy as the new President of Molecular Devices, ... by Molecular Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University ... recently invested in BioFactura’s $6M Series B Financing Round. , “With the ... investors who bring significant financial and business resources to bear as we advance ...
(Date:5/31/2019)... ... 31, 2019 , ... The OilComm Conference & Exposition, held ... that Ben Reiter, Senior Writer at Sports Illustrated and Author of Astroball, will ... predicted the Houston Astros would win the MLB championship in 2014 when they ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than ... Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday ... detailed the results of some research carried out by the association, in partnership ...
(Date:5/2/2019)... Md. (PRWEB) , ... April ... ... to the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. ... meet customer requirements. In addition, REPROCELL USA Inc. aims to enhance customer ...
(Date:5/2/2019)... (PRWEB) , ... May 02, 2019 , ... Stay on ... biotech, medical device and food industries. Access to all webinars is free, so be ... relevant in your field! , Visit http://www.xtalks.com to see our upcoming webinars: ...
(Date:5/2/2019)... ... May 02, 2019 , ... Boston ... greater Boston area. Gone are the days of painful hair transplant procedures. Boston ... Restoration System is the only robotic intelligent solution to offer a minimally invasive ...
Breaking Biology Technology: