Navigation Links
BGI develops new strategy to uncover structural variations of human genomes
Date:7/25/2011

enotypes previously difficult to define by other approaches.

Through this new method, researchers identified 277,243 SVs, ranging from 1bp to 23kbp in assembled regions of both genomes. Meanwhile, the researchers performed validation using computational and experimental methods and the results indicated a high accuracy of detection. They also carried out characterization of genome-wide patterns of these SVs on different genomic features and studied their potential biological impacts. Profiling using 106 individuals of the 1000 Genomes Project indicates that the extent of diversity in SVs between individuals exceeds that of SNPs. These findings demonstrate whole genome de novo assembly could serve as a new solution to a more comprehensive SV map.

"Here we provide a new method, at a relatively low cost and high speed, to establish in greater detail the presence and patterns of SVs in different genomes, and the results have a high accuracy and a wider range of length spectrum coverage in comparison with previous methods," said Honglong Wu, bioinformatician at BGI and one senior author of the study.

Furthermore, researchers reported, SVs are more individual-specific than SNPs, which may play a significant role underlying the phenotypic differences between individuals. "This study makes us understand we need to consider all kinds of genetic variations and potential differences in their impacts on disease and various other phenotypes in medical genomics studies in the future." added Yingrui Li.

Professor Jun Wang, Executive Director of BGI, said, "With further progresses in de novo assembling by new technologies, assembly-based approaches will be of greater importance and potentially an ultimate solution to SV determination. The study of SVs is likely to attract even more attention in the future."

This study also reveals that de novo assembly can develop more complete personal genomes than resequencing based mapping. Research
'/>"/>

Contact: Lei Su
BGI-Marketing@genomics.cn
86-075-525-283-805
Beijing Genomics Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Iowa State researcher develops new treatment method for canine eye diseases
2. Hypertension develops early, silently, in African-American men
3. MIT develops new way to fuse cells
4. Fujitsu Develops HDD Security Technology Based on Opal SSC Standards
5. When acute hepatitis develops into chronic hepatitis
6. MIT student develops new innovations to selectively kill cancer cells
7. CSHL team develops mouse models of leukemia that predict response to chemotherapy
8. HudsonAlpha investigator develops rapid response swine flu test
9. Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
10. Epigentek Develops a New Method of Measuring Global DNA Methylation
11. GSU professor develops new method to help keep fruit, vegetables and flowers fresh
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... the first to show that while the impact of ... negative effects may be reduced by maintaining a healthy ... participants who exercised, slept well and ate well had ... healthy lifestyles, even when they had similar levels of ... in the department of psychiatry at UCSF. "It,s very ...
(Date:7/28/2014)... discovery of two additional coral communities showing signs of damage ... of the 2010 spill in the Gulf of Mexico. The ... professor of biology at Penn State University. A paper describing ... in the Gulf of Mexico will be published during the ... of the journal Proceedings of the National Academy of ...
(Date:7/28/2014)... led by the University of Arizona has sequenced the ... will enhance scientists, and agriculturalists, understanding of the growing ... development of new rice varieties that are better able ... global hunger challenges. , The paper, "The genome sequence ... for independent domestication," was published online in Nature ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4
... and the United States have completed the draft genome ... bacteria that cause citrus canker. Citrus canker, a belligerent ... the United States, South America, and Asia, causes millions ... of citrus crops such as oranges, limes, and grapefruit. ...
... evolve or not to evolve? That is the question scientists ... answering following a groundbreaking new study into the colourful hamlet ... in the vast marine environment. The new findings, published online ... significantly improve our understanding of speciation the evolutionary process ...
... defend themselves in some way, they would certainly be gobbled ... little insects to large mammalian herbivores. Indeed, not only ... kind of defense. When a plant has several options, ... the same tissues or defend different tissues in different ways? ...
Cached Biology News:Genomes of citrus canker pathogens decoded 2Genomes of citrus canker pathogens decoded 3Hamlet fish sheds light on evolution of marine species 2Making its predators tremble: Multiple defenses act synergistically in aspen 2Making its predators tremble: Multiple defenses act synergistically in aspen 3
(Date:7/29/2014)... The first product launch from start-up ... to robotics. What sets Droidles completely apart from other ... allows them to communicate, share code with each other ... , “The invention is the system,” said Hurley Research ... life of their own, both physically and on the ...
(Date:7/29/2014)... The prestigious "Discovery or Exploration in History ... to Juliana Hillis and Kaylie O’Connell, students at Stoneham ... an Egg, Everything: America’s First IVF Baby". This project ... National History Day program during a week-long final competition ... Washington, D.C. , The growing popularity of the assisted ...
(Date:7/29/2014)... White papers by Clinovo on ... technologies, have been published by leading pharmaceutical publications Data ... line of white papers by Clinovo to have been ... Pharmaceutical Online, and OpenHealthNews. , At the request of ... Marc Desgrousilliers, 'The Five Essentials of Cloud Computing ...
(Date:7/29/2014)... 2014 PlaqueTec ... Erfassung biologischer Daten in Verbindung mit Herzerkrankungen ... Das LBS nimmt gleichzeitig mehrere Blutproben von ... und sucht erhöhte biologische Aktivitäten in erkrankten ... Entdeckung und Entwicklung neuer Medikamente und Therapeutika ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4
... A discovery by scientists at the University of East ... that use domestic or agricultural waste to generate clean ... Proceedings of the National Academy of Sciences ... the mechanism by which some bacteria survive by ,breathing ...
... , , FREMONT, Calif., Dec. ... a leading developer of state-of-the-art genetic analysis systems, today ... Panel for its innovative service for gene-expression profiling using ... Panel provides the most comprehensive human microRNA panel of ...
... , , , , WALTHAM, Mass., Dec. ... research and advisory firms for pharmaceutical and healthcare issues, ... Ortho Biotech/Janssen-Cilag,s Stelara and Abbott,s briakinumab (both interleukin inhibitors) ... 2012 in the drug market for moderate to severe ...
Cached Biology Technology:'Rock-breathing' bacteria could generate electricity and clean up oil spills 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 3WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 4In 2012, Stelara and Briakinumab Will Capture 22 Percent of the Biologics Share in the Moderate to Severe Psoriasis Drug Market 2In 2012, Stelara and Briakinumab Will Capture 22 Percent of the Biologics Share in the Moderate to Severe Psoriasis Drug Market 3
Human Cell Line Slides...
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... Each Signet Level 2 Detection System ... avidin-biotin chemical bonding principle and Signets ... provide sensitivity, specificity and reliablility. Signet ... in both manual and automated protocols. ...
6X DNA Gel Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Biology Products: