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BGI announces collaboration with Johns Hopkins University on synthetic yeast project

l, experience and ability in the research of synthetic biology, we believe we can achieve significant breakthroughs in the future study of synthetic biology."

Synthetic biology aims to design synthetic biological systems utilizing genetic engineered micro-organisms for the production of biofuels and drugs. It can help scientists to understand the living system of natural organisms, such as biological mechanisms, responses and adaptation to various environmental conditions, evolution, among others. Synthetic biology is expected to provide ground breaking applications with engineered biology systems designed and built to help in the production of chemicals, energy and food to maintain and enhance human health and the environment.

With a well-understood genome and the wide applications of yeast in bioremediation, food processing, medicine, etc, yeast has been an excellent model organism used in the studies of synthetic biology. In the SC2.0 PROJECT, the yeast S. cerevisiae is used as the basis for a newly engineered life form that resulted from specific alternations incorporated into the synthetic chromosomes. The "synthetic yeast" approach can be used to answer a wide variety of profound questions about fundamental properties of chromosomes, genome organization, gene content, the function of RNA splicing, and questions relating to genome structure and evolution.

The rapid development of high-throughput sequencing technology has led to a boom in genomic information of different organisms, which also facilitates the rapid detection and identification of synthetic systems and organisms. Meanwhile, it could help synthetic biologists to verify an engineered biological system as proposed, given that the DNA sequences of the single gene or entire genome are designed by computer and then built by chemical synthesis.

"As the first artificial eukaryotic cell genome project, SC2.0 PROJECT will play a significant role in the history of the

Contact: Jia Liu
BGI Shenzhen

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