SHENZHEN, China, June 5, 2011 /PRNewswire/ --
Following previous efforts (http://www.genomics.cn/en/news_show.php?type=show&id=644 and http://www.genomics.cn/en/news_show.php?type=show&id=647), BGI, based in Shenzhen, China, and its collaborators at the University Medical Centre Hamburg-Eppendorf, as well as a growing number of researchers around the world "crowdsourcing" this data, are exploring in-depth the European disease outbreak helping trace the origin and spread of the lethal E. coli strain. Different sources have reported that two strains, 01-09591 from Germany isolated in 2001 and 55989 from Central Africa in 2002, are highly similar to the 2011 outbreak strain. Based on the most recently curated assembly publically released by BGI yesterday (ftp://ftp.genomics.org.cn/pub/Ecoli_TY-2482), these strains have an identical Multi Locus Sequence Typing (ST678) based on analysis of seven important "housekeeping" genes*.
BGI's latest analysis indicates that the two German strains (01-09591 originally isolated in 2001 and TY2482 from the 2011 outbreak) have identical profiles for all 12 virulence/fitness genes and seven MLST housekeeping genes. However, at some point over this 10-year period the new 2011 outbreak strain seems to have developed the ability to resist many additional types of antibiotics. The latest data is now pointing to this candidate, as it now seems the African strain (strain 55989) is genetically more "distant" as the Shiga-toxin-producing gene and tellurite-resistan
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