Navigation Links
BGI Tech develops whole exome sequencing analysis of FFPE DNA samples to boost biomedicine
Date:9/18/2012

September 18, 2012, Shenzhen, China BGI Tech Solutions Co., Ltd. (the "BGI Tech"), a subsidiary company of BGI, announced today that they have achieved whole exome sequencing analysis of total degraded DNA as low as 200 ng from formalin fixed paraffin embedded (FFPE) samples. This advancement enables researchers to efficiently uncover the genetic information from FFPE disease samples such as cancers and infectious diseases, with the advantages of high reliability, accuracy and fast turnaround time.

FFPE samples are the most common biological materials for disease diagnoses and clinical studies. Especially in cancer research, millions of FFPE archival cancer tissue samples provide an enormous and invaluable repository of information, which hold a wealth of data for the discovery of biomarkers, drug development as well as diseases diagnosis and treatment.

However, during the FFPE sample preparation and storage process, the effect of formaldehyde on nucleic acids is detrimental, which can induce modification of nucleotide molecules, such as DNA damage, DNA-protein cross-links (DPC), among others. This may lay problems for researchers to get enough high-quality DNA from these FFPE samples to comprehensively explore the genetic characteristics of diseases, especially for some rare tumors.

FFPE samples are a unique sample type with a lot of challenges, and researchers from BGI Tech have optimized the DNA extraction, library construction and sequencing pipelines of FFPE DNA samples. At present, DNA as low as 200 ng from FFPE samples can be used for whole exome sequencing. To insure the accuracy and quality of sequencing, researchers evaluated the FFPE DNA sequencing results and demonstrated that FFPE exome sequencing could maintain the equivalent accuracy and reliability with the normal DNA sample sequencing.

It is reported that ~85% of genetic diseases are related with exome variations. Whole exome sequencing is a robust innovative technique tha
'/>"/>

Contact: Jia Liu
liujia@genomics.cn
BGI Shenzhen
Source:Eurekalert

Page: 1 2

Related biology news :

1. IU chemist develops new synthesis of most useful, yet expensive, antimalarial drug
2. MMV develops framework to assess risk of resistance for antimalarial compounds
3. US-Russian collaboration develops new method for sequencing dark matter of life from a single cell
4. University of Illinois professor develops tool that helps dietitians deliver info clients need and can understand
5. Pitt develops biodegradable artery graft to enhance bypass surgeries
6. MindSpec develops Autism Quiz app
7. Geneticist develops tool to identify genes important in disease, tailoring individual treatment
8. Pod corn develops leaves in the inflorescences
9. Genetic research develops tools for studying diseases, improving regenerative treatment
10. Diabetes Research Institute develops oxygen-generating biomaterial
11. Prenatal whole genome sequencing: Just because we can, should we?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... 2015  Trovagene, Inc. (NASDAQ: TROV ), ... the launch of a study that aims to ... (PCM) technology for predicting response to treatment in ... of the novel immunotherapy agents Yervoy® (ipilumumab), a ... The 50-patient study will be led by researchers ...
(Date:7/7/2015)... , July 7, 2015 NXT-ID, Inc. (NASDAQ: ... on the growing mobile commerce market announces a revised version of ... week. The commercial will air on CNBC in New ... Angeles and San Francisco metro ... commercial focuses on Wocket,s ability to replace all the cards in ...
(Date:6/30/2015)... -- To bolster its efforts and commitment to fighting cyber ... addition of two new team members. ... David Raviv will act as head of strategic alliances. ... providing the most secure solutions for the enterprise market. ... Technologies, a provider of security and management products, which was ...
Breaking Biology News(10 mins):Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3
... is relentless and terminal. Auguries and alchemists, mendicants and magicians, ... employed all their various arts in the pursuits of "turning ... a span of a century to our name, at most. ... that determine life span still elude us? If ...
... At the time of birth, mouse ovaries are ... primordial follicles are forming. This key time in ovarian ... instigates evelopment of a cohort of follicles. If follicles ... oocytes are also essential for follicular development. Several factors ...
... at St. Jude Children,s Research Hospital have gained new ... workhorses called calpains. As the cell,s molecular ... movement of cells in tissues, the death of damaged ... The downside of this broad set of responsibilities is ...
Cached Biology News:Fountain of Youth to be found in the anthill? 2Fountain of Youth to be found in the anthill? 3Fountain of Youth to be found in the anthill? 4December 2008 highlights from Biology of Reproduction 2New insight into the controls on a go-to enzyme 2New insight into the controls on a go-to enzyme 3
(Date:7/31/2015)... ... July 31, 2015 , ... ... detection and quantification of partially hydrolyzed gluten in foods, has been accepted by ... the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report ... the current state of the global Propanol market with a focus on the Chinese ... Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and ...
(Date:7/30/2015)... ISN improves the efficiency and effectiveness of contractor management systems. ISN,s online contractor management ... over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Dallas, TX , ISN has additional offices in Calgary , ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's Pony™ NS2006L ... operation up to 1500 bar. The sanitary design gauge of the NS2006L is ... , The Pony™ NS2006L homogenizer is an ideal solution for the processing of ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... may pose the next significant security threat to information technology ... the second annual survey on IT security and the workforce ... ,The survey of nearly 900 organizations found that 36.8 ... the last six months. Thats up from 25 percent in ...
... Berbee Information Networks Corp . President Paul Shain ... as part of Accelerate Madisons monthly meeting. According to Shain, ... the aftermath of the dot-com era as other information technology-focused ... , the company was founded on the dogma of creating ...
... my top priority has been growing the state's lagging ... on Job Creation, many pro-job initiatives authored and vetted ... bi-partisan basis. These bills have improved the state's energy ... a foundation for a more vibrant venture capital market. ...
Cached Biology Technology:Browser-based attacks may pose next big IT security nightmare 2Berbees success is based on companys history and culture 2Berbees success is based on companys history and culture 3Berbees success is based on companys history and culture 4Broadband freedom mandatory for growth 2
Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
The BD CBA Human Apoptosis Kit can be used to quantitatively measure,cleaved PARP, Bcl-2, and active Caspase-3 protein levels in a single sample. The,Kit performance has been optimized for analysis o...
... proteases/caspases initiates apoptosis in mammalian cells. ... provides a simple and convenient means for ... in intact cells. The assay utilizes ... linked to rhodamine 110 (D2R), a reported ...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
Biology Products: