Navigation Links
BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients
Date:3/24/2008

BARACLUDE (entecavir) in nucleoside-nave and lamivudine-refractory studies was also evaluated.

Data Results

Results from these studies prior to this year five analysis were previously announced on April 14, 2007.

Nucleoside-nave data

  • The incidence of BARACLUDE resistance in patients in nucleoside-nave studies over time is low, with a cumulative probability of genotypic BARACLUDE resistance of 1.2 percent through five years.
  • No nucleoside-naive patient developed resistance (n=108) in year five.
  • 93 percent of the nucleoside-naive patients taking BARACLUDE were able to achieve and maintain an undetectable viral load (HBV DNA < 300 copies/mL) through year five (n=108).

Lamivudine-refractory data

  • The results in lamivudine-refractory patients in years one through five were consistent with the finding that the pre-existence of lamivudine-resistant substitutions resulted in an increase in the emergence of BARACLUDE resistance, with a cumulative probability of genotypic resistance of 51 percent through five years.
  • In year five, 43 percent of lamivudine-refractory patients had virologic breakthrough with BARACLUDE resistance (n=33).
  • During this resistance monitoring program, 72 of the 187 lamivudine-refractory patients achieved undetectable viral load ( < 300 copies/mL) and of these, three patients subsequently developed genotypic resistance to BARACLUDE.

Indication and Important Safety Information About BARACLUDE (entecavir) 0.5 mg/1 mg Tablets


'/>"/>

Contact: Hilary Mra
mrah@ruderfinn.com
212-593-6414
Ruder Finn Public Relations
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover new strategies for antibiotic resistance
2. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
3. Binghamton University researchers investigate evolving malaria resistance
4. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
5. Feline virus, antiviral drug studied to understand drug resistance
6. Manure management reduces levels of antibiotics and antibiotic resistance genes
7. High degree of resistance to antibiotics in Arctic birds
8. Gene that controls ozone resistance of plants could lead to drought-resistant crops
9. First orchid fossil puts showy blooms at some 80 million years old
10. ESA celebrates 100 years of insect science journals
11. Researchers detect hint of oxygen 50 to 100 million years earlier than first believed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, reminds investors and media ... Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held ... The three-day conference is organized into a ... in is themed Global Fraud: Where is the Trust ...
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... under attack by toxic seaweed do what anyone might do when ... in the journal Science shows that threatened corals send ... noxious alga which can kill the coral if not promptly ... evidence that these "mutualistic" fish respond to chemical signals from the ...
... This press release is available in German . ... in multicellular organisms. Because of their potent effects, the production ... That is the key finding of a new study performed ... Biology. They identified a new component that modulates the production ...
... 126,000 sites across the U.S. have contaminated groundwater that requires ... "complex," meaning restoration is unlikely to be achieved in the ... a new report from the National Research Council. The ... these sites ranges from $110 billion to $127 billion, but ...
Cached Biology News:Corals attacked by toxic seaweed use chemical 911 signals to summon help 2Corals attacked by toxic seaweed use chemical 911 signals to summon help 3Corals attacked by toxic seaweed use chemical 911 signals to summon help 4MicroRNAs in plants: Regulation of the regulator 2MicroRNAs in plants: Regulation of the regulator 3Report: Cleanup of some contaminated groundwater sites unlikely for decades 2Report: Cleanup of some contaminated groundwater sites unlikely for decades 3
(Date:5/27/2015)... -- Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ) ("NW Bio"), ... cancer, announced today that Dr. Marnix L. Bosch ... making an Industry Expert Theater Presentation at the 2015 ... on Saturday, May 30, 2015, from 3 to 4 ... Place. Dr. Bosch will provide an overview ...
(Date:5/27/2015)... 2015  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... status of the Company,s Series A and Series ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO At March ... of Series A Preferred Stock and Series A-1 ...
(Date:5/26/2015)... Regenestem Network has announced the ... Buenos Aires, Argentina. The clinic will be lead by ... has assembled a multidisciplinary team of medical professionals who ... Puerto Madero office. , The new Regenestem Network ... clinical studies in cellular therapies, and establish Regenestem protocols ...
(Date:5/26/2015)... and HILDEN, Germany , May ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) ... Clinical Insight ® (QCI™) bioinformatics content and ... and report on genomic variants identified in next-generation ... the bioinformatics platform are in oncology, for somatic ...
Breaking Biology Technology:NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5
... Growth Rates Under 1 Percent Since 2000,Partnership Will Target Acceleration and ... ... Banos, Philippines (vocus) March 3, 2009 -- DuPont and ... partnership to boost rice yields. The Scientific Know-How and Exchange ...
... 3 Zymetis Inc., a biotechnology company focused on ... today announces it was named a 2009 GoingGreen East ... "greentech" companies in the Eastern U.S. and Canada. ... given to emerging companies creating new green technology businesses. ...
... Informed Medical Communications (IMC), a leading provider of ... announced the appointment of Kerry Crawford to the ... this critical role, Kerry will lead operations and ... relationship management systems. This key addition is ...
Cached Biology Technology:DuPont and International Rice Research Institute Partner to Boost Rice Yields 2DuPont and International Rice Research Institute Partner to Boost Rice Yields 3Zymetis Inc. Named Top 50 'Cleantech/Greentech' Company 2Informed Medical Communications Appoints New Senior Manager, Strategic Operations 2
Recombinant Rat Leptin, CF...
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Polaroid black & white positive, 3 x 4 inch pack film, ISO 3000/ 36 ASA DIN (20 expsures). For use in the Polaroid Direct Copy Camera (PHC34)....
Applications: (+) Immunocytochemistry and immunohistochemistry...
Biology Products: