Navigation Links
B vitamins in mother's diet reduce colorectal cancer risk in offspring
Date:6/9/2011

BOSTON (June 9, 2011) − Mice born to mothers who are fed a diet supplemented with B vitamins are less likely to develop intestinal tumors, report scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University.

Previous research in humans and mice suggests that B vitamins, particularly folate, play a role in the prevention of colorectal cancer. Using a mouse model of naturally occurring colorectal cancer, the USDA HNRCA scientists examined whether a mothers' B vitamin intake impacts her offspring's cancer risk. Mothers were fed diets containing supplemental, adequate or mildly deficient quantities of vitamins B2, B6, B12 and folate prior to conception through weaning after which all of the offspring received the same adequate diet.

"We saw, by far, the fewest intestinal tumors in the offspring of mothers consuming the supplemented diet," says Jimmy Crott, PhD, senior author and a scientist in the Vitamins and Carcinogenesis Laboratory at the USDA HNRCA. "Although the tumor incidence was similar between offspring of deficient and adequate mothers, 54% of tumors in the deficient offspring were advanced and had invaded surrounding tissue while only 18% of tumors in the offspring of adequate mothers displayed these aggressive properties."

The results were published online June 9 in the journal Gut.

Crott and colleagues associated the tumor suppression seen in the offspring of supplemented mothers with a protection against disruptions to the 'Wnt' signaling pathway, a network of genes commonly altered in colorectal cancer.

"The strongest expression of tumor-suppressing genes in the Wnt pathway was in the offspring of supplemented mothers and the weakest was in the offspring of the mildly deficient mothers," says first author Eric Ciappio, a PhD candidate at the Friedman School of Nutrition Science and Policy at Tufts.

"We attribute these differences in gene expression to epigenetics, modifications of DNA which are sensitive to environmental factors such as diet," Ciappio continues. "In this case, changing maternal B vitamin intake had lasting epigenetic effects in offspring and may explain the differences in tumor incidence and aggressiveness we observed".

It remains unclear whether maternal consumption of the four B vitamins could impact tumor development in humans. ""While evidence is beginning to accumulate to suggest that maternal consumption of supplements containing folate may afford some protection against childhood cancers in offspring, we don't yet have the ability to determine whether the same holds true for cancers that normally present in the mid to late decades of life," explains Crott, who is also an assistant professor at the Friedman School.

Crott adds, "Aside from the known protective effect of maternal folate against neural tube defects such as spina bifida, our results suggest that mothers consuming supplemental quantities of these B vitamins may also be protecting her children against colorectal cancer."


'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

Related biology news :

1. Women who start prenatal vitamins early are less likely to have children with autism
2. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
3. New mothers can learn a lot from watching their babies
4. Parenting stress affects new mothers’ postpartum lifestyle
5. Preterm mothers milk contains less antioxidants than mothers completing their gestation
6. Mothers diets have biggest influence on children eating healthy
7. New report suggests why risk for sudden infant death syndrome is greater in babies of mothers who smoke
8. Successful mothers get help from their friends: Dolphin study
9. Discus fish parent young like mammalian mothers
10. Black mothers cite lack of desire as top reasons for not breastfeeding
11. About 94 percent of breastfeeding mothers do not follow a proper diet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Facial ... offering. --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... Markets ( http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ...
(Date:2/3/2016)... , Feb. 3, 2016 Vigilant Solutions ... Police Department in Missouri solved ... plate reader (LPR) data from Vigilant Solutions. ... case in which the victim was walking out of a convenience store and ... space next to his vehicle, striking his vehicle and ...
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... HILDEN , Germany and ... QGEN ; Frankfurt Prime Standard: ... new QIAseq Targeted RNA Panels for gene expression profiling, ... next-generation sequencing (NGS). The panels enable researchers to select ... expression fold changes and discover interactions between genes, cellular ...
(Date:2/11/2016)... 2016  Spectra BioPharma Selling Solutions (Spectra) is ... biopharma companies the experience, expertise, operational delivery and ... sales teams. Created in concert with industry leading ... strategic and tactical needs of its clients by ... both personal and non-personal promotion. ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... cutting-edge information focused on the development and manufacture of biopharmaceuticals and therapeutics, ... sponsor of the 2016 BioProcess International Awards – Recognizing Excellence in the ...
(Date:2/11/2016)... DELRAY BEACH, Florida , February 11, 2016 ... --> PositiveID Corporation ("PositiveID" or "Company") (OTCQB: ... and diagnostics, announced today that its Thermomedics subsidiary, ... significant progress on its growth plan in January ... healthcare products distributors, increasing sequential monthly sales growth, ...
Breaking Biology Technology: