Navigation Links
B vitamins in mother's diet reduce colorectal cancer risk in offspring
Date:6/9/2011

BOSTON (June 9, 2011) − Mice born to mothers who are fed a diet supplemented with B vitamins are less likely to develop intestinal tumors, report scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University.

Previous research in humans and mice suggests that B vitamins, particularly folate, play a role in the prevention of colorectal cancer. Using a mouse model of naturally occurring colorectal cancer, the USDA HNRCA scientists examined whether a mothers' B vitamin intake impacts her offspring's cancer risk. Mothers were fed diets containing supplemental, adequate or mildly deficient quantities of vitamins B2, B6, B12 and folate prior to conception through weaning after which all of the offspring received the same adequate diet.

"We saw, by far, the fewest intestinal tumors in the offspring of mothers consuming the supplemented diet," says Jimmy Crott, PhD, senior author and a scientist in the Vitamins and Carcinogenesis Laboratory at the USDA HNRCA. "Although the tumor incidence was similar between offspring of deficient and adequate mothers, 54% of tumors in the deficient offspring were advanced and had invaded surrounding tissue while only 18% of tumors in the offspring of adequate mothers displayed these aggressive properties."

The results were published online June 9 in the journal Gut.

Crott and colleagues associated the tumor suppression seen in the offspring of supplemented mothers with a protection against disruptions to the 'Wnt' signaling pathway, a network of genes commonly altered in colorectal cancer.

"The strongest expression of tumor-suppressing genes in the Wnt pathway was in the offspring of supplemented mothers and the weakest was in the offspring of the mildly deficient mothers," says first author Eric Ciappio, a PhD candidate at the Friedman School of Nutrition Science and Policy at Tufts.

"We attribute these differences in gene expression to epigenetics, modifications of DNA which are sensitive to environmental factors such as diet," Ciappio continues. "In this case, changing maternal B vitamin intake had lasting epigenetic effects in offspring and may explain the differences in tumor incidence and aggressiveness we observed".

It remains unclear whether maternal consumption of the four B vitamins could impact tumor development in humans. ""While evidence is beginning to accumulate to suggest that maternal consumption of supplements containing folate may afford some protection against childhood cancers in offspring, we don't yet have the ability to determine whether the same holds true for cancers that normally present in the mid to late decades of life," explains Crott, who is also an assistant professor at the Friedman School.

Crott adds, "Aside from the known protective effect of maternal folate against neural tube defects such as spina bifida, our results suggest that mothers consuming supplemental quantities of these B vitamins may also be protecting her children against colorectal cancer."


'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

Related biology news :

1. Women who start prenatal vitamins early are less likely to have children with autism
2. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
3. New mothers can learn a lot from watching their babies
4. Parenting stress affects new mothers’ postpartum lifestyle
5. Preterm mothers milk contains less antioxidants than mothers completing their gestation
6. Mothers diets have biggest influence on children eating healthy
7. New report suggests why risk for sudden infant death syndrome is greater in babies of mothers who smoke
8. Successful mothers get help from their friends: Dolphin study
9. Discus fish parent young like mammalian mothers
10. Black mothers cite lack of desire as top reasons for not breastfeeding
11. About 94 percent of breastfeeding mothers do not follow a proper diet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... MELBOURNE, Florida , March 14, 2016 ... on the growing mobile commerce market, announces the airing of ... York channels starting the week of March 21 st . ... and CNBC, including its popular Squawk on the Street show. ... company focused on the growing mobile commerce market, announces the ...
(Date:3/10/2016)... PUNE, India , March 10, 2016 ... to a new market research report "Identity and Access ... SSO, & Audit, Compliance, and Governance), by Organization Size, ... Forecast to 2020", published by MarketsandMarkets, The market is ... to USD 12.78 Billion by 2020, at a Compound ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... Israel , May 24, 2016   MedyMatch Technology ... physicians with artificial intelligence, real-time decision support tools in the ... present at the 2016 Israeli Advanced Technology Industries (IATI) BioMed ... Israel,s 15th National Life Sciences and ... at the David Intercontinental Hotel in Tel Aviv, ...
(Date:5/23/2016)... Willoughby, Ohio (PRWEB) , ... May 23, 2016 ... ... Six Trends That Will Drive Precision Farming in 2017 and Beyond. The paper ... and practitioners in the precision ag industry. , “We’ve witnessed a lot of ...
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a leading ... in Aurora, Ohio, has broken ground on a new building in Holly Springs, ... area, this new location solidifies a commitment to business in the region. The ...
(Date:5/20/2016)... ... May 20, 2016 , ... Kablooe Design, a leading provider of product ... official 25th anniversary of the business. “We have worked hard to build long-term relationships,” ... for the privilege and honor of serving their product design and development needs through ...
Breaking Biology Technology: