Navigation Links
Awake mental replay of past experiences critical for learning
Date:5/3/2012

ocampus become associated with a particular place. These place cells fire when the animal is that place or it turns out is just mentally replaying the experience of being in that place.

In the experimental situation, the rat needs to learn a rule to get a reward. It must remember which of two outer arms of a W-shaped maze it had visited previously and alternate between them visiting the opposite arm after first visiting the center arm. The ripple activity occurs when rats are inactive during breaks between trials.

Place cells associated with the maze fire in rapid succession and in synchrony with other neurons in the neighborhood. The same place cells fire in the same sequence as they did when the rat first walked through the maze suggesting that the rat is mentally replaying the earlier experience, but on a much faster timescale.

In the current study, an automatic feedback system shut down place cell firing, via mild electrical stimulation, whenever it detected ripple activity, thereby also preventing the replay of the maze memory. Without benefit of mental replay, rats' performance on the maze task deteriorated. The impairment was in the animals' spatial working memory their ability to link immediate and earlier past experience to the reward. This ability was required to correctly decide which outside arm to visit after exiting the center arm during outbound trials.

The researchers propose that awake replay in the hippocampus provides such information about past locations and future options to the brain's executive hub, the prefrontal cortex, which learns the alternation rule and applies it to guide behavior.

Even though the replay events in rats last just a fraction of a second, Frank notes that they are not unlike our own experience of memories, which tend to compress often lengthy events into snippets of just the highlights of what happened to us.

"We think the brain is using these same ripple-li
'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Innovative research reawakens human memories through intelligent textiles
2. Fat clue to TB awakening
3. Will giving coffee to babies keep them awake as adults?
4. Re-awakening old genes to help in the fight against HIV
5. Could genetic research awaken racist attitudes?
6. Study finds Western diet detrimental to fetal hippocampal tissue transplants
7. New genes contributing to autism and related neurodevelopmental disorders uncovered
8. Long-term research reveals causes and consequences of environmental change
9. Stomata development in plants unraveled -- a valuable discovery for environmental research
10. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
11. Record-breaking grant: New research project to investigate the causes of mental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Awake mental replay of past experiences critical for learning
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
(Date:4/10/2015)... 2015 Research and Markets ( ... "Security Competitive Profiles - NEC" report to their ... NEC will continue to supply a range of IT ... a company focus on the development of a Big ... opportunities in the Asia-Pacific region ...
(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... This release is also available in Spanish . ... Pediatrics of the University of Granada , ... 16 European countries, will study the effects of childrens ... allergies, weak bones, neuromotor functioning and childrens behavioural aspects. ...
... -- Proteins, the biological molecules involved in virtually every ... ways, according to a recent study from the U.S. ... new light on how proteins interact with drugs and ... to behave similarly in regions of high and low ...
... including biologists from NOAAs Fisheries Service, reported in the ... vaquita, a porpoise found in the Gulf of California, ... levels that their rate to extinction will increase and ... vaquita remain. The research team, led by Armando ...
Cached Biology News:Scientists study the link between children's nutrition and adult diseases 2New Argonne study may shed light on protein-drug interactions 2New Argonne study may shed light on protein-drug interactions 3
(Date:4/17/2015)... SYDNEY , April 17, 2015  US-Australian drug ... signed a Memorandum of Understanding with the Feinstein ... New York to collaborate with ... cancers. The collaboration brings together the ... and clinical expertise of the Feinstein Institute in ...
(Date:4/16/2015)... Bythewood, South Carolina (PRWEB) April 17, 2015 ... solutions and steam system services, released their newly ... 2015. The customer facing website effectively promotes ... proposition. , All the information that a ... training, steam system services, company capabilities, industries serviced, ...
(Date:4/16/2015)... Capillus, LLC announces plans to expand ... Europe and Asia. The Miami-based medical device manufacturer ... Business Development Director of Svenson Group Europe, as ... professional achievements include increasing the number of Svenson ... the Portuguese marketplace with centers in Lisbon and ...
(Date:4/16/2015)... 2015 According to the 2014 ... outside source was ranked first among the leading ... to lifting, pushing, pulling, holding, carrying, or throwing ... The David Round Company takes statistics like this ... hard to develop and design equipment that prevents ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6Spirax Sarco website has a new look 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... Baxa Corporation announces its,2008 sponsorship for the Colorado ... of MicroPhage Inc.) recognized Baxa, along with,the other ... held April 29th at the University Club in ... CBSA since its inception. Company founder Brian,Baldwin was ...
... FRANKLIN LAKES, N.J., May 1 Brian T. Griffin,group ... MHS ),is scheduled to address the Deutsche Bank ... The company presentation at the Intercontinental Boston, will begin ... Robert S.,Epstein, MD, MS, will participate in a panel ...
... May 1 Osteotech, Inc.,(Nasdaq: OSTE ), a ... healing, announced today that revenue for the first quarter ... for the first,quarter of 2007. Revenue from the Company,s ... was $17.6 million for the three,months ended March 31, ...
Cached Biology Technology:Baxa Announces Colorado BioScience Association Sponsorship 2Baxa Announces Colorado BioScience Association Sponsorship 3Medco to Present at the Deutsche Bank 33rd Annual Health Care Conference 2Osteotech Posts First Quarter Earnings Per Share of $.05 on Revenue Growth of 10% 2Osteotech Posts First Quarter Earnings Per Share of $.05 on Revenue Growth of 10% 3Osteotech Posts First Quarter Earnings Per Share of $.05 on Revenue Growth of 10% 4Osteotech Posts First Quarter Earnings Per Share of $.05 on Revenue Growth of 10% 5
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: