Navigation Links
Avoiding Spleen Removal for Cooley's Anemia SufferersAvoiding spleen removal for Cooley's anemia suf
Date:5/27/2008

ull and face, osteopenia, and demineralization of the bones, which are then prone to fractures. Despite excessive erythropoietic activity, affected persons suffer from anemia, which is exacerbated by progressive splenomegaly and an increase in plasma volume as a result of shunting through the expanded marrow.

Splenectomy (Removal of Spleen)

After splenectomy, patients are considered immunocompromised, and so should be placed on lifelong prophylactic oral antibiotics. Patients should also be vaccinated against common viral infections, and should receive annual influenza vaccinations.

Researchers are still learning about the health effects that stem from years of living with reduced or deficient globin proteins. An emerging realization is that removal of the spleen can cause an increase in the risk of life-threatening blood clots. Splenectomy is common for thalassemia patients because their red blood cells are crippled or dead, so the spleen has to work overtime and can become enlarged.

Researchers disagree on the degree of risk associated with splenectomy. A study by Dr. M. Domenica Cappellini, a co-author of this research, found that 30 percent of splenectomized thalassemia intermedia patients developed clots. However, a recent study of 8,860 splenectomized patients with thalassemia major and thalassemia intermediate found that the rate of thrombolytic events was 1.75 percent.

Surgical technique has played a role in developing clots (thrombosis). A recent study found that patients who underwent open splenectomy had a 19 percent chance of developing life-threatening clots, whereas patients who had laparoscopic surgery had a 55 percent chance.

Researchers are only now discovering why splenectomy leads to clots. Injury of endothelial cells may lead to a coagulation cascade, involving the activation of endothelial adhesion proteins, monocytes, granulocytes and platelets. Alternatively, the splenectomy might re
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Canada provides $1.4M for removal of hazardous trees from provincial recreation sites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... the brains of all vertebrates, information is transmitted ... or chemical signal to be passed from one ... the most abundant type of synapse, can be ... for learning, memory, perception and cognition, and the ... brain function. For instance, every time we ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2Blame it on the astrocytes 2
... researchers and engineers try to shrink diagnostics to fit in ... and mix small samples of liquid. University of Washington researchers ... drops along certain paths to conduct medical or environmental tests., ... want, and in any kind of layout that we want," ...
... Germany, 9 May 2012 Fifty-five life scientists from ... EMBO for their excellence in research. Forty-eight of the ... scientists from Argentina, Australia, South Korea and the United ... now comprises almost 1,550 life scientists in the international ...
... team of researchers, working on behalf of the European ... upper level for vitamin A consumption for puppies. The ... of science-based recommendations for vitamin A levels for puppies ... This research was conducted by scientists from ...
Cached Biology News:Portable diagnostics designed to be shaken, not stirred 2Collaborative research team identifies safe upper level for vitamin A consumption for puppies 2
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... been awarded a $1 million grant from the W.M. ... developing a new microscope that uses a light-guiding "metamedium" ... with significantly improved clarity. The nanoscale coaxial optical ... microscopes known as "superlenses," which function far differently than ...
... MON ) will hold a webcast next Wednesday ... president – global strategy, at the Goldman Sachs Agricultural Biotech ... 9.   Preete will discuss the company,s business ... to the business. Slides and a simultaneous ...
... by a Barrow Neurological Institute scientist on the thermoregulatory effects ... pain is the cover story in the Feb. 2 issue ... conducted by an international team led by Andrej Romanovsky, MD, ... which is a part of St. Joseph,s Hospital and Medical ...
Cached Biology Technology:Boston College receives W.M. Keck Foundation funding for nanoscale optical microscope 2Barrow TRPV1 research highlighted in Journal of Neuroscience 2
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
SHEEP ANTI HUMAN ESTRONE...
Biology Products: