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Automated microfluidic device reduces time to screen small organisms for genetic studies
Date:6/23/2008

a sorting speed of approximately 150 animals per hour and a false negative rate of less than 0.2 percent, indicating that almost all the mutants were captured by the system.

A third experiment was aimed at demonstrating the ability of the system to screen organisms based on micro-sized synaptic features of the animals. Results showed that the system was able to sort mixed populations at a rate of approximately 400 animals per hour for this application. In all three experiments, it would have taken researchers much longer to identify the worms manually with high-resolution microscopy a few worms at a time.

"This is the first automated device to combine high-resolution imaging with automated sorting of the worms." added Lu. "Now that we have the automated system, we are able to perform genetic screens a lot faster than what has traditionally been done and speed up the discovery of new genes, new functions and new pathways."


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Contact: Abby Vogel
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404-385-3364
Georgia Institute of Technology Research News
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