Navigation Links
Automated microfluidic device reduces time to screen small organisms for genetic studies
Date:6/23/2008

cause unlike commonly-used anesthetic drugs, the cooling doesn't have long-term effects.

After cooling, the system uses a high-resolution microscope to acquire multi-dimensional images of the animal on-chip.

"The advantage of using our microchip is that it's completely compatible with any standard microscope you'd find in a biology laboratory epifluorescence, stereo, multi-photon or confocal with no modification required," explained Lu.

The researchers have shown that the intensity and patterns of fluorescent markers imaged inside cooled animals versus those in anesthetized animals exhibit no discernible differences. Based on each animal's phenotype, or how each animal looks under the microscope, the computer identifies whether it is wild-type or mutant and sorts it into the appropriate group.

Initial tests to assess the system were conducted on C. elegans, one of the tiniest multi-cellular organisms that share many fundamental cellular/molecular mechanisms with more advanced organisms. However, the automated system can also be adapted to study other small organisms such as fruit flies and fish embryos.

For one experiment, Lu and her team tested the ability of the system to analyze the gene expression pattern the intensity, location and timing of appearance of a fluorescent protein in a population of organisms. They were able to sort the free-moving animals into two categories, those fluorescing in a particle neuron and those that are not, at a speed of approximately 900 animals per hour. More than 90 percent of the animals were loaded into the observation chamber within 0.3 seconds after the previous animal exited.

In another experiment, the researchers were successful in separating a small number of mutant animals from a large population of wild-type animals based on the fluorescence in a single pair of neurons. With on-line processing and decision-making without human supervision, the system achieved
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. San Diego Harbor Police Deploy BIO-key(R) Automated Vehicle Location System
2. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
3. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
4. Does fishing on drifting fish aggregation devices endanger the survival of tropical tuna?
5. New Silex SX-560 Enables Enterprise 802.11 Wireless Connectivity for Battery Operated Devices
6. Scientists test device to track medication adherence in patients with HIV/AIDS
7. Needle-size device created to track tumors, radiation dose
8. Childrens Hospital leads projects to develop nations first heart assist devices for young children
9. Biosensing nanodevice to revolutionize health screenings
10. Analysis calls for medical device information to better serve patients and doctors
11. Portable device quickly detects early Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Automated microfluidic device reduces time to screen small organisms for genetic studies
(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... Medicine announced today that it is a Grand ... Bill & Melinda Gates Foundation. Laura Goetzl, ... Sciences; and Vice Chair of Research and Academic ... pursue an innovative global health and development research ... Neurodevelopment.", Grand Challenges Explorations (GCE) funds individuals worldwide ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
... that can break down plant biomass into the precursors of ... to produce alternatives to petroleum. But the potential of this ... cannot break down lignin, a highly stable polymer that makes ... Streptomyces bacteria are among few microorganisms known to ...
... 14, 2013As scientists continue to unravel the complexity of the ... role in both normal physiology and disease, one particular class ... attention. Guest Editor Tom Cech, PhD and Executive Editor Fintan ... advancing research area in their Editorial " The (Noncoding) ...
... Studies at Le Bonheur Children,s Hospital in Memphis, ... RSV, replicate in humans, mutate to avoid the immune ... DeVincenzo, MD, medical director of Molecular Diagnostics and Virology ... Microbiology, Immunology, and Molecular Biology at The University of ...
Cached Biology News:A microbial biorefinery provides new insight into how bacteria regulate genes 2A microbial biorefinery provides new insight into how bacteria regulate genes 3Noncoding RNAs offer huge therapeutic and diagnostic potential 2Leading RSV researcher publishes work at Le Bonheur Children's 2Leading RSV researcher publishes work at Le Bonheur Children's 3
(Date:11/22/2014)...   , ... zu KLOX    Mariano ... Officer bestellt    KLOX ist bestens ... zugelassenen Behandlungssystems zur Wundheilung zu beginnen    , ... sehr erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... , Nov. 21, 2014   TRU-D SmartUVC LLC ... their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS ... from Nov. 23 to 26 at Stand 23. ... United Kingdom,s largest infection-related event of ... societies to one of the leading events of its type ...
(Date:11/21/2014)... Offering a complete line of laboratory ... promotion . The Sartorius Entris Balance is the perfect ... and easy-to-maintain balance entry level balance. , The Entris ... to help customer’s bridge the gap between a basic ... very durable. Sartorius is the second biggest balance manufacturer ...
(Date:11/21/2014)... Palo Alto, Calif. (PRWEB) November 20, 2014 ... (CHI), a nonprofit, public policy research organization representing ... and pharmaceutical firms, and PwC US ... other states in life sciences industry growth. The ... and 2013. The 2015 California Biomedical Industry ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4
... 220 V, is used for agitation and mixing ... staining and destaining of gels and blots, and ... (8-40 rpm) and can handle a maximum load ... two 29 x 21 cm platforms covered with ...
...
...
... Wyatt Technology's family of light scattering instruments. ... temperature chromatograph and enables you to get ... The HTmD is easily installed in the ... Alliance 2000 device and enables you to ...
Biology Products: