Navigation Links
Autologous bone marrow-derived mononuclear cell transplants can reduce diabetic amputations
Date:4/18/2012

Tampa, Fla. (April. 18, 2012) Autologous (self-donated) mononuclear cells derived from bone marrow (BMMNCs) have been found to significantly induce vascular growth when transplanted into patients with diabetes who are suffering from critical limb ischemia caused by peripheral artery disease (PAD), a complication of diabetes. The team of researchers in Seville, Spain who carried out the study published their results in a recent issue of Cell Transplantation (20:10), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Critical limb ischemia in diabetic patients is associated with high rates of morbidity and mortality; however, neovascularization induced by stem cell therapy could be a useful approach for these patients," said study corresponding author Dr. Bernat Soria of the Andaluz Center for Biologic and Molecular Regenerative Medicine in Seville, Spain. "In this study we evaluated the safety and efficacy of inter-arterial administration of autologous bone marrow-derived mononuclear cells with 20 diabetic patents with severe below-the-knee arterial ischemia."

The researchers noted that surgical or endovascular revascularization options for patients such as those in the study are limited because of poor arterial outflow. Although optimum dose, source and route of administration were outstanding questions, proper BMMNC dose for best results was an issue that the researchers hoped to clarify. They subsequently used a dose ten times smaller than other researchers had used previously in similar studies.

According to the authors, the rationale for their study was that intra-arterial infusions of autologous BMMNCs contain endothelial progenitors that are locally profuse at severely diseased vascular beds in the lower limb. Their hope was that the BMMNCs could promote early and effective development of new vascularization.

Patients were
'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
2. Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
3. High blood sugars impact on immune system holds clues to improving islet cell transplants
4. Researchers engineer pancreatic cell transplants to evade immune response
5. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
6. Gene mismatch influences success of bone marrow transplants
7. Bone marrow cell transplants to benefit those with heart disease
8. Cell transplants may benefit children with cerebral palsy
9. Frozen flies may yield secrets for human organ transplants
10. Free radicals in cornea may contribute to Fuchs dystrophy, most common cause of corneal transplants
11. Stem cell transplants help kidney damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... to two-thirds of Earth,s permafrost likely will disappear by ... quantities of carbon into the atmosphere, says a new ... for Research in Environmental Sciences. The ... to thaw in high latitudes from warming temperatures, which ...
... CHAMPAIGN, lll. University of Illinois animal sciences professor ... Prize in Agriculture. He shares the prize with James ... Wolf Prizes are awarded each year, with recipients in ... prize committee selected Lewin for his "highly significant discoveries" ...
... proteins in the blood of pregnant women that could be ... in discovery of biomarkers that seem to be specific enough ... a new study in ACS,s Journal of Proteome Research ... happens when an embryo does not attach normally inside the ...
Cached Biology News:Thawing permafrost likely will accelerate global warming 2Thawing permafrost likely will accelerate global warming 3Illinois professor awarded 2011 Wolf Prize in Agriculture 2
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - The ... partners are pleased to announce the formation of ... on developing treatments for cancer that harness the ... represents a unique collaboration between the Children,s Hospital ... Research Institute, McMaster University, the Ontario Institute for ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Achieved primarily ... produces slides that boast 10 to 100x better detail ... the capabilities of all existing light microscopy methods, it ... micrographs were chosen as the frame of reference because ... , The goal from the earliest discovery days ...
(Date:5/4/2015)... 4, 2015 - New Massive ... students prepare for the United States Medical Licensing Examination ... scientific, technical and medical information products and services, announced ... Open Online Course) designed to help medical students prepare ... 1, the first and most daunting of the three ...
(Date:5/4/2015)... ALISO VIEJO, Calif. , May 4, 2015 /PRNewswire/ ... to eliminate preventable hospitalizations, has teamed with the ... effect of Sentrian technology on 1,000 patients with chronic ... nearly 13 million Americans and is the nation,s third ... plan members of CareMore Health System , a ...
Breaking Biology Technology:Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 2CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 3CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 4CareMore, Scripps Translational Science Institute, and Sentrian Launch Landmark Study of Remote Patient Monitoring for COPD Population 5
... a three-year Phase II small business innovation research ... Institute for Environmental Health Sciences. , ,The grant ... for the measurement of low-dose, cumulative exposure to ... sensitive, inexpensive, rugged and suitable for studies involving ...
... heavy damage from Hurricane Charley, which threatened Tampa, Fla., ... Carolina. Source: Beau McCune. MADISON Insurance companies ... to speed claims processing for disaster victims. These companies ... process their portion of the $7.4 billion in losses ...
... argue about improvement. Motherhood, apple pie, the Packers, Badgers and ... apt to cause a fight after a few beers. Everyone ... things worse the next time. Einstein's theory of human nature ... defined insanity as doing the same things over and over ...
Cached Biology Technology:Wisconsins insurance companies use advanced IT to speed relief 2Wisconsins insurance companies use advanced IT to speed relief 3The Real World 2The Real World 3
... synthetic peptide whose sequence corresponds to residues 1-18 from rat rab ... terminus): M(1) - A - S - A - S - ... - R - D - A - A - D - ... neutralization and control experiments with the polyclonal antibody that reacts with ...
... RNA sequences from high throughput synthesis are new ... LC Sciences. These products provide a large number ... sequences delivered in a microtube as a mixture ... verified RNA sequence. This is a custom product ...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: