Navigation Links
Autism susceptibility genes identified
Date:3/25/2010

Two genes have been associated with autistic spectrum disorders (ASD) in a new study of 661 families. Researchers writing in BioMed Central's newly launched journal Molecular Autism found that variations in the genes for two brain proteins, LRRN3 and LRRTM3, were significantly associated with susceptibility to ASD.

Anthony Monaco from the Wellcome Trust Centre for Human Genetics, University of Oxford, UK, worked with an international team of researchers to study four candidate genes in families from the UK, the Netherlands, Italy and Germany. He said, "To our knowledge, this is one of the most comprehensive genetic analyses of association between these important genes in brain connections and ASD risk". The proteins encoded by these two genes have been implicated in brain development, which is often impaired in autistic individuals. In particular, LRRN3 is thought to play a role in the development and maintenance of the nervous system, while LRRTM3 is part of a family of proteins thought to organize synaptic connections.

According to Monaco, " A focused candidate gene study was carried out using association approaches to identify common variants in the UK cohort and in additional European populations. This study covered four brain-enriched leucine-rich repeat candidates and taken together, there is converging evidence that common genetic variants in LRRTM3 and LRRN3 confer susceptibility to ASD. Future studies of these genes and their function will provide valuable insights into their role in ASD pathogenesis".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. A better genetic test for autism
2. Research builds on genetic link to autism and schizophrenia
3. Brain study offers insight into causes of autism
4. Autism Speaks presents the top ten autism research findings of 2009
5. UC Davis study confirms link between advanced maternal age and autism
6. Autism Speaks responds to recent publications citing autism clusters in California
7. Research adds to evidence that autism is a brain connectivity disorder
8. Uniform method to interpret autism spectrum disorders is defined at Ben-Gurion University
9. Pediatrics GI recommendations -- first step to guidelines for children with autism
10. 1 percent -- 1 in 110 -- CDC issues new autism prevalence report
11. Treatments for asthma and pre-term labor may increase risk of autism in developing fetus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... surprising discoveries about the body,s initial responses to ... team found that specialized cells in the intestine ... invasion and are the source of gut inflammation ... , Though aimed at the presence of ... that provides a barrier to protect the body ...
(Date:8/29/2014)... at the Barshop Institute for Longevity and Aging Studies, ... Health Science Center at San Antonio, have found another ... rodent, the naked mole rat. , They reported ... rats protects and alters the activity of the proteasome, ... The factor also protects proteasome function in human, mouse ...
(Date:8/29/2014)... about what genetic changes transform wild animals into domesticated ... is a University of Montana assistant professor, has made ... of the brain and the nervous system were particularly ... 28 in Science and gives answers to ... ., The domestication of animals and plants, a prerequisite ...
Breaking Biology News(10 mins):The early cost of HIV 2Factor in naked mole rat's cells enhances protein integrity 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
... from Asia, transpacific dust plumes deliver vast quantities of ... online ahead of print in the journal Applied ... of unique microbial species, many of which seem particularly ... Smith, a graduate student at the University of Washington, ...
... landscape design feature. Planting trees on your property can ... carbon footprint. A new online tool developed by the ... of Forestry and Fire Protection (CAL FIRE),s Urban and ... owners estimate these tangible benefits. Using a ...
... This press release is available in German ... for hospitals and nursing homes worldwide. Propagation of bacterial resistance ... urgent. Scientists at the Max Planck Institute for Biophysical Chemistry ... fight bacteria: the factor EF-P. EF-P plays a crucial role ...
Cached Biology News:Dust-plumes power intercontinental microbial migrations 2New online tool estimates carbon and energy impact of trees 2Achilles' heel of pathogenic bacteria discovered 2Achilles' heel of pathogenic bacteria discovered 3
(Date:8/29/2014)... 29, 2014  Pfenex Inc. (NYSE MKT: PFNX), ... of high-value and difficult to manufacture proteins including ... reported financial results for the second quarter ended ... completion of our initial public offering, we have ... product candidates, derived from our proprietary protein expression ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... 2014 The global companion diagnostics ... 2019. It is expected to grow at a ... was valued at $1.8 billion in 2013, according ... Research. , For more information regarding analysis details ... The research report, titled “Companion Diagnostics Market (Breast ...
(Date:8/29/2014)... 29, 2014 According to a new market ... global orthobiologics market was valued at USD 3,754.6 million in ... 5,519.9million in 2019at a CAGR of 5.9% from 2013 to ... and above is afflicted by bone and joint disorders, and ... 2020. This has and will continue to increase the demand ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... The global biotechnology industry will face many serious ... regulatory fights to the rigors of engineering better biofuels ... with what immediately confronts the 20,000 convention visitors at ... really believe? , ,A walk-through in Chicago's massive ...
... floor to rival any industry trade show, but Doug Tucker didn't come ... The BIO Chicago show floor, the size of three football fields, ... expect any of our end-user customers in the form of physicians, etc., ... said. "This is a probably a better way for us to ...
... to comply with federal requirements, Fiserv, Inc. ... a partner in providing multifactor authentication technology to its ... as financial institutions are under obligation, by the end ... Council requirements to evaluate and strengthen their customer authentication ...
Cached Biology Technology:My-oh, it's BIO! Where sales hype and science collide 2As BIO shows mass of competition, hunt for partners is on 2As BIO shows mass of competition, hunt for partners is on 3
Monocarboxylate (lactate) transporter 2...
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: