Navigation Links
Australian study sheds light on kidney repair and disease
Date:9/30/2009

A study by Monash University researchers has shed new light on the microscopic antennas in the kidney that are involved in the organ's repair process.

The work may be a crucial step towards a cure for polycystic kidney disease, a potentially fatal disease that affects more than one in 1000 people.

The study, led by Dr James Deane a researcher at the Centre for Inflammatory Disease at the Monash Medical Centre, showed how kidney repair processes are controlled and helps explain the cause of polycystic kidney disease.

The findings have appeared in the latest edition of world's leading kidney research publication, the Journal of the American Society of Nephrology.

"We have shown for the first time that the hair-like structures on kidney cells, called cilia, change their length in response to injury in human patients, growing up to four times their original length in the later stages of kidney repair," Dr Deane said.

"These hair-like structures are antennas and the increases in their length amplify the signals they send to kidney cells at vital stages of repair. We think this is how they turn off the repair process when it is complete and allow the kidney to start working normally again"

Dr Deane said that if the switching on and off the repair process is not properly controlled, rapidly reproducing cells will distort the tubes of the kidney and prevent them from functioning properly, which is what appears to happen in people that have polycystic kidney disease, a condition which is currently untreatable.

"Our research helps put a logical framework behind what is happening in polycystic kidney disease, as the mutations that cause the disease can damage the hair-like structures of kidneys cells," Dr Deane said.

"We hope that this work will lead to new ways of treating both kidney injury and polycystic kidney disease."

The kidney is made up of about a million tiny living tubes that produce urine to rid the body of waste products. The cells that make up these tubes have hair-like structures, which are two thousandths of a millimetre long and respond to urine flow by sending reassuring signals back to the cells.

In an injured kidney there is a reduction in urine flow and reassuring signals from the hair-like structures are diminished. This causes kidney cells go into repair mode. Surviving kidney cells take on a new form that allows them to reproduce rapidly to replace cells that have died. When enough cells have been produced it is important that kidney cells stop reproducing and return to their normal form. This is where some extra input from the hair-like structures appears to be required.


'/>"/>

Contact: Dr James Deane
james.deane@med.monash.edu.au
61-395-945-528
Monash University
Source:Eurekalert

Related biology news :

1. Invasive Australian jellyfish sighted in Gulf of Mexico in summer 2007
2. Australian researchers develop treatment to treat obesity
3. Fertilizer research center an Australian first
4. Oldest Australian crayfish fossils provide missing evolutionary link
5. Australian frog species chooses not to put eggs in 1 basket
6. Crafty Australian crayfish cheat
7. Australian filmmakers are stars of science film awards
8. Energy experts helping Australian households reduce carbon emissions
9. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
10. A study by the MUHC and McGill University opens a new door to understanding cancer
11. Study begins to reveal clues to the cause and progression of sepsis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical ... data and document anonymization solution on October 4, 2017. Shadow is ... field to comply with policy 0070 of the European Medicines Agency ... data. ... GCE Solutions ...
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... and business process optimization firm for the life sciences and healthcare industries, announces ... conference in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud ...
Breaking Biology Technology: