Navigation Links
Australian researchers develop treatment to treat obesity
Date:11/6/2007

A team of researchers from the St Vincents Campus in Sydney have developed a novel way to control the extreme weight loss, common in late stage cancer, which often speeds death.

The findings, published in Nature Medicine, suggest it may soon be possible to prevent this condition, giving people the strength to survive treatment and improve their chances of recovery.

The team of researchers from the Centre for Immunology at St Vincents Hospital and the University of New South Wales and the Garvan Institute of Medical Research have shown that most common cancers produce large amounts of a molecule known as MIC-1, which in turn targets receptors in the brain that switch off appetite. Antibodies against MIC-1, already developed by St Vincents, make it possible to switch appetite back on.

Conversely, when normal and obese mice are treated with MIC-1, they eat less and lose a lot of weight, suggesting that MIC-1 may also form the basis of a treatment for severe obesity.

Professor Sam Breit at the Centre for Immunology originally cloned the MIC-1 gene. He discovered that blood levels of MIC-1 were high in many patients with advanced cancers, and correlated this with the extreme weight loss seen in these patients.

In a collaboration with Professor Herbert Herzog, Director of the Neuroscience Research Program at Garvan they then analysed the effect of this molecule on metabolism and the brain control of appetite.

This work has given us a better understanding of the part of the brain that regulates appetite. Our bodies send complex chemical signals to our brains, which interpret them and send back responses, in this case eat or dont eat. Our research indicated that MIC-1 is a previously unrecognised molecule sending a dont eat signal to the brain, said Professor Herzog.

The study showed that if a human cancer making a lot of MIC-1 is grafted onto a mouse, that mouse lost weight dramatically. When the researc
'/>"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
Source:Eurekalert

Page: 1 2

Related biology news :

1. Invasive Australian jellyfish sighted in Gulf of Mexico in summer 2007
2. Researchers identify proteins involved in new neurodegenerative syndrome
3. Texas researchers and educators head for Antarctica
4. MGH researchers describe new way to identify, evolve novel enzymes
5. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. UIC researchers find promising new targets for antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... other chronic inflammatory disorders among people of lower socioeconomic ... exposure to the microbes that thrive in rural environments, ... published in the journal Clinical & Experimental Immunology ... have less access to green spaces may be more ... immune system dysfunction. , When our immune systems are ...
(Date:4/23/2014)... most in their mid-thirties and forties, face a ... within two decades. "Mutant" protein clusters, long blamed ... been the primary focus of therapies in development ... from Prof. Gerardo Lederkremer and Dr. Julia Leitman ... and Immunology, in collaboration with Prof. Ulrich Hartl ...
(Date:4/23/2014)... Valley, NY. (Apr. 23, 2014) People who have ... potential to restore neurological function. However, a study conducted ... issue of Cell Transplantation , but is currently ... http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1168Chen , has found that when one group ... cells (PBSCs) injected directly into the brain and a ...
Breaking Biology News(10 mins):Rural microbes could boost city dwellers' health 2Rural microbes could boost city dwellers' health 3On the defensive 2On the defensive 3Autologous stem cell therapy improves motor function in chronic stroke victims 2
... relocation of an Inuit village already underway, some 400 ... in Alaska for a UN-affiliated conference April 20-24 to ... to both mitigate and adapt to climate change. ... Global Summit on Climate Change is also designed to ...
... Biology 2009 meeting in New Orleans, Dr. Kristine ... Control Technologies Branch of the Health Effects Laboratory ... results from the first study to directly link ... with exposure to different vibration frequencies with biological ...
... grew warmer from 18,700 to 10,000 years ago, juniper trees ... of their favorite food. Now, University of Utah biologists have ... eat toxic creosote bushes that replaced juniper. "It was ... Dearing, senior author of the study, published online Tuesday, April ...
Cached Biology News:Indigenous peoples at world summit to share climate change observations, coping techniques 2Indigenous peoples at world summit to share climate change observations, coping techniques 3Indigenous peoples at world summit to share climate change observations, coping techniques 4Indigenous peoples at world summit to share climate change observations, coping techniques 5Indigenous peoples at world summit to share climate change observations, coping techniques 6Risk of vibration-induced vascular injuries linked to vibration frequency differences 2Poison: It's what's for dinner 2Poison: It's what's for dinner 3Poison: It's what's for dinner 4Poison: It's what's for dinner 5
(Date:1/15/2014)...  Bill Jacobs Automotive, a group of car dealerships headquartered in ... Heartland Blood Center and offering free oil change coupons for ... Saturday, Jan. 18 at the Bill Jacobs Cadillac and Chevrolet ... http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs Auto ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... IPSWICH, England , January 15, 2014 ... to win races on the Formula 1 track could help ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based ... funded by healthcare provider Simplyhealth. Telemetry technology, which ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... - GeneNews Limited (TSX: GEN), a company focused on ... diseases and personalized health management, today announced that it ... being held at the Sheraton Centre in Toronto from ... booth # 400, will feature the Company,s lead product, ...
... and CAMBRIDGE, England, November 26 Sosei,Group Corporation ("Sosei"; ... it has out-licensed its IP and Know How,relating to ... a,Cambridge, UK based pharma company, for the treatment and ... Mefloquine is a highly efficacious anti-malarial drug that is ...
... CAS REGISTRY, the world,s most,authoritative collection of disclosed chemical ... CAS Registry Number(R),1073662-18-6 recently was assigned to an azulenobenzofuran ... http://www.newscom.com/cgi-bin/prnh/20081125/CLTU095 ) , ... The 40 millionth substance ...
Cached Biology Technology:GeneNews to exhibit ColonSentry(TM) at Family Medicine Forum 2008 2Sosei Announces the Out-licensing of RS(+) Mefloquine to Treague Ltd for the Treatment and Prophylaxis of Malaria 2CAS Registers 40 Millionth Substance in CAS REGISTRY(SM) 2
A univariate (peak height or area) quantitative multi-component analysis package....
... The micro 1 is a dramatic breakthrough ... from 1mL with 10nL resolution, the micro 1 ... benchtop dispenser. And, the micro 1 never needs ... , Touch Screen programming on an LCD Display ...
... microscopes offer all of the features of ... Equipped with Koehler illumination, a centerable condenser ... B3 is the workhorse of Motic's range ... the need for re-focusing following a change ...
... Dye Primer Manual Cycle Sequencing Kit is ... primers and high-resolution fluorescence scanners. Sequencing reactions ... slab gel electrophoresis and scanning of the ... The kit components have been optimized ...
Biology Products: