Navigation Links
Atomic structure of the mammalian 'fatty acid factory' determined
Date:9/5/2008

Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase. Their results have just been published in Science magazine.

Synthesis of fatty acids is a central cellular process that has been studied for many decades. Fatty acids are used in the cell as energy storage compounds, messenger molecules and building blocks for the cellular envelope. Until now, individual steps of this process have been investigated using isolated bacterial enzymes. However, in higher organisms except plants fatty acid synthesis is catalyzed by large multifunctional proteins where many individual enzymes are brought together to form a "molecular assembly line".

The atomic structure is the result of many years of research

As described in this week's issue of "Science" magazine, researchers at ETH Zurich, supported by the National Centre of Excellence in Research (NCCR) in Structural Biology at the Swiss National Science Foundation, determined the high-resolution structure of a mammalian fatty acid synthase using data collected at the Swiss Light Source (SLS) of the Paul Scherrer Institute (PSI) in Switzerland. These results crown the efforts begun in 2001 to determine the detailed structures of fatty acid synthases in higher organisms by a relatively small group of scientists at ETH Zurich. The group, consisting of Timm Maier, Marc Leibundgut and Simon Jenni in the laboratory of Prof. Nenad Ban, published their first papers describing architectures of fungal and mammalian fatty acid synthases two years ago. That was followed last year by two papers on the atomic structures of fungal fatty acid synthases and the mechanism of substrate shuttling and delivery in these multi-enz
'/>"/>

Contact: Professor Nenad Ban
nenad.ban@mol.biol.ethz.ch
41-446-332-785
ETH Zurich/Swiss Federal Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists retrace evolution with first atomic structure of an ancient protein
2. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
3. Poxvirus potency uncovered in new atomic map
4. Bikini corals recover from atomic blast
5. New nano-positioners may have atomic-scale precision
6. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
7. Structure of 450 million year old protein reveals evolutions steps
8. A step toward tissue-engineered heart structures for children
9. Scientists learn structure of enzyme in unusual virus
10. Using nanotubes to detect and repair cracks in aircraft wings, other structures
11. Unveiling the structure of microcrystals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... ( AURORA, CO) The vast majority of pediatricians and ... HPV) vaccine, though fewer physicians are strongly encouraging it for ... to a survey in the September issue of Pediatrics ... Funded by the Centers for Disease Control and Prevention, ...
... Relieving poverty during pregnancy can reduce the incidence of ... childhood poor health, a study published in the August 2010 ... found. How healthy a baby is at birth can ... education, and adult health, according to the study led by ...
... A possible cause of irritable bowel syndrome has been traced ... protecting the colon membrane, leading to hostile conditions that can ... shows that this RNA segment sends signals that stop the ... Previous research has linked a shortage of glutamine in the ...
Cached Biology News:Doctors not strongly encouraging HPV vaccine to girls of certain age 2Sociological study links state tax credit programs to higher birth weight 2Scientists target possible cause of 1 form of bowel disease 2Scientists target possible cause of 1 form of bowel disease 3
(Date:5/5/2015)... RURO, Inc., a leading LIMS, RFID ... the latest major content upgrade to its bestselling, Commercial ... Upgrade is a significant advancement of FreezerPro® system ... experience, while also simplifying , New ... Download available immediately for free to “Gold” ...
(Date:5/5/2015)... CA (PRWEB) May 05, 2015 ... Life Science Animal Health, Jeffrey Schaffer, DVM, as ... “With over 15 years of experience in the ... a great addition to our veterinarian lead organization”. ... Officer, explains. “Dr. Schaffer will be responsible for ...
(Date:5/5/2015)... IN (PRWEB) May 05, 2015 The ... the state of Indiana, led by Indiana Gov. Mike ... Day. The AMA Foundation will host a Family Fest ... celebration. All proceeds will benefit the Wounded Warrior Project. ... the Academy of Model Aeronautics—the country’s foremost organization for ...
(Date:5/5/2015)... and WASHINGTON, D.C., USA (PRWEB) May 05, 2015 ... U.S. export regulations covering a wide range of key ... say are hampering global competitiveness of U.S. industry. To ... a webinar on 12 May on the ... which governs the commodities covered by International Traffic in ...
Breaking Biology Technology:RURO Releases version 7 of FreezerPro® software 2Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2State of Indiana proclaims August 15 as Model Aviation Day 2Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4
... ANGELES, April 28 MMR Information Systems (OTC ... subsidiary, MyMedicalRecords, Inc. (collectively, "MMR") provides Web-based consumer-controlled ... ) and electronic safe deposit box storage solutions ... free Personal Health Record and free surgical masks ...
... Diagnosis, Locations, and Research Benefit Regional Cancer PatientsNEW ORLEANS, ... ) and LSU Health Sciences Center , ... a partnership to better serve the region,s cancer patients ... to advance patient treatment options and provide better access ...
... efficacious for both prophylactic and therapeutic treatmentsVIENNA, ... AMEX: CVM ) announced today ... utilizing its proprietary L.E.A.P.S.(TM) (Ligand Epitope Antigen ... protection against illnesses such as swine influenza. ...
Cached Biology Technology:MMR Offers Free Surgical Masks to Call Attention to Importance of Personal Health Records in Preparing for Possible Swine Flu Pandemic 2MMR Offers Free Surgical Masks to Call Attention to Importance of Personal Health Records in Preparing for Possible Swine Flu Pandemic 3MMR Offers Free Surgical Masks to Call Attention to Importance of Personal Health Records in Preparing for Possible Swine Flu Pandemic 4Ochsner and LSUHSC Partner to Provide Better Local Access to Comprehensive Cancer Care 2CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies 2CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies 3
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Recognizes a full-length CLC-2 voltage-gated Cl- protein and not with other known proteins tested so far....
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Sheep polyclonal to ErbB 2 ( Abpromise for all tested applications). Antigen: Recombinant full length c-ErbB2 protein (Human). Entrez GeneID: 2064 Swiss Protein ID: P04626...
Biology Products: