Navigation Links
Atomic-scale structures of ribosome could help improve antibiotics
Date:5/19/2011

It sounds like hype from a late-night infomercial: It can twist and bend without breaking! And wait, there's more: It could someday help you fend off disease!

But in this case it's true, thanks to scientists from several institutions including the U.S. Department of Energy's Lawrence Berkeley National Laboratory. They derived atomic-scale resolution structures of the cell's protein-making machine, the ribosome, at key stages of its job.

The structures, developed primarily at Berkeley Lab's Advanced Light Source, reveal that the ribosome's ability to rotate an incredible amount without falling apart is due to the never-before-seen springiness of molecular widgets that hold it together.

The structures also provide an atom-by-atom map of the ribosome when it's fully rotated during the final phase of protein synthesis. Many antibiotics target the ribosomes of disease-causing microbes at precisely this stage. The high-resolution structures could allow scientists to develop antibiotics that better target this cellular Achilles' heel, perhaps leading to drugs that are less susceptible to resistance.

"Parts of the ribosome are much more flexible than we previously thought. In addition, now that we have a fully rotated ribosomal structure, scientists may be able to develop new antibiotics that are not as sensitive to ribosomal mutations. This could help mitigate the huge problem of multidrug resistance," says Jamie Cate, a staff scientist in Berkeley Lab's Physical Biosciences Division and an associate professor of biochemistry, molecular biology, and chemistry at the University of California at Berkeley.

Cate conducted the research with a team that includes scientists from Cornell University and Duke University. Their research is published in the May 20 issue of the journal Science.

The ribosome works like a protein assembly line. Its smaller subunit moves along messenger RNA, which contributes genetic in
'/>"/>

Contact: Dan Krotz
dakrotz@lbl.gov
510-486-4019
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Caltech chemists develop simple technique to visualize atomic-scale structures
2. Carbon nanostructures form the future of electronics and optoelectronics
3. Structures of important plant viruses determined
4. Study of protein structures reveals key events in evolutionary history
5. Researchers develop flow sensors based on hair structures of blind cavefish
6. Researchers gain genome-wide insights into patterns of the worlds human population structures
7. Researchers observe single protein dimers wavering between two symmetrically opposed structures
8. University of Miami receives stimulus funds for study of hurricane impacts on structures, ecosystems
9. Video gamers: Size of brain structures predicts success
10. Emerald BioStructures announces discovery of small molecule modulators of PDE4
11. Air Force Center of Excellence awarded in nanostructures and improved cognition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Atomic-scale structures of ribosome could help improve antibiotics
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ( ... Voice Biometrics - Global Strategic Business Report" report to their ... and Voice Biometrics in US$ Thousands by the following Segments: Face ... the US, Canada , Japan ... Middle East & Africa ...
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has ... Strategic Business Report" report to their offering. ... US$ Thousands. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... can be a shrewd hunter himself. A University of ... lures to hunt their prey. Vladimir Dinets, ... is the first to observe two crocodilian speciesmuggers and ... during nest-building time. The research is published ...
... of the University of Massachusetts Medical School (UMMS) has ... and Drug Administration (FDA) for MBL-HCV1, a monoclonal antibody ... patients receiving a liver transplant. Complications from ... liver transplantation today. For patients with end-stage liver disease ...
... , Dec. 4, 2013 /PRNewswire-iReach/ -- The 2013 ... and figures. Worldwide markets for biometrics are poised ... electronics in their personal life, protection of individual ... protect individual information. (Photo: http://photos.prnewswire.com/prnh/20131204/MN27463 ...
Cached Biology News:University of Tennessee study finds crocodiles are cleverer than previously thought 2MassBiologics receives orphan drug status from FDA for hepatitis C treatment 2Biometrics Market Forecasts: Fingerprint Technologies, Facial and Iris Reading Algorithms Analyzed in New Research Reports 2Biometrics Market Forecasts: Fingerprint Technologies, Facial and Iris Reading Algorithms Analyzed in New Research Reports 3Biometrics Market Forecasts: Fingerprint Technologies, Facial and Iris Reading Algorithms Analyzed in New Research Reports 4Biometrics Market Forecasts: Fingerprint Technologies, Facial and Iris Reading Algorithms Analyzed in New Research Reports 5
(Date:4/17/2015)... Calif. , April 17, 2015 /PRNewswire/ ... received a SBIR grant from the National ... National Institutes of Health (NIH). The grant ... efforts in the development of breakthrough genomic ... using specially fabricated substrates. Centrillion has been ...
(Date:4/17/2015)... - SQI Diagnostics Inc. (TSX-V: SQD; OTCQX: SQIDF), a ... commercializes proprietary technologies and products for advanced microarray ... approval from the TSX Venture Exchange to extend ... warrants ("the Warrants") of the Company, which were ... private placement financing. Each Warrant entitles ...
(Date:4/17/2015)... April 17, 2015 Global Stem ... GTCbio Stem Cell Summit 2015 April 27 - 29, ... latest developments in all areas of stem cell research ... stem cells and regenerative medicine. , The conference ... as well as translational research in stem cell therapies, ...
(Date:4/16/2015)... 2015 Spirax Sarco, the leader ... their newly designed, state-of-the-art website in the first ... effectively promotes the Spirax Sarco brand, company capabilities, ... that a site visitor might be looking for ... industries serviced, the latest company news, careers, and ...
Breaking Biology Technology:SQI Diagnostics to Extend Warrant Expiry 2SQI Diagnostics to Extend Warrant Expiry 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Spirax Sarco website has a new look 2
... , INDIANAPOLIS , ... and manufacturing companies continued to expand in 2009, despite challenges ... in the economy, the prospect of healthcare reform and other ... announced, and service line extensions were added by companies such ...
... , New kinase array designed for ... VANCOUVER , Feb. 10 /PRNewswire/ - ... novel Protein Kinase Microarray with 200 recombinant human protein ... applications for drug target counter screening, to identify novel ...
... ... users to search the most sought after jobs in the industry anytime, anywhere. ... (PRWEB) -- MedReps.com gives members ... on the web. But in a competitive market like medical sales, job seekers need every ...
Cached Biology Technology:Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 2Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 3Indiana Biopharmaceutical Service Providers Maintain Steady Growth Despite Industry Challenges 4Kinexus Announces the Launch of a New Protein Kinase Microarray 2With the MedReps.com iPhone App, the Medical Sales Job Search Goes Mobile 2
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
Bag-1 (K-20)...
IC50: 35 ng/ml · Limit of detection: 8 ng/ml...
... PGE2-d4 contains 4 deuterium atoms at ... It is intended for use as an ... E2 (PGE2) by GC- or LC-mass spectrometry. ... products of arachidonic acid and one of ...
Biology Products: