Navigation Links
Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
Date:10/7/2008

F domains.

"The addition of a simple, small molecule to the GAF domain affects the entire PDE enzyme," Heikaus said. Researchers think the binding to the domain may act as a switch that turns on the enzyme.

The research findings were published in the Sept. 19 Journal of Biological Chemistry. The article was selected as a Paper of the Week. The journal cover featured a striking image of the iris of Heikaus' eye, photographed by UW ophthalmology imaging supervisor Brad Clifton. Superimposed in the center of the pupil was a three-dimensional structure of the GAF domain.

In humans, GAF-containing proteins are rare. In plants and bacteria, GAF domains are widespread and are specialized for binding a variety of molecules. Some of these plant and bacteria GAF domains are important in detecting light, but they do so through a mechanism that is completely different from vision in vertebrate animals.

GAF domains emerged more than 3 billion years ago in early forms of life, and remained as animals and humans evolved, a phenomenon evolutionary biologists call conservation. Human GAF domains have similar protein folds, and a similar way of binding signal-triggering molecules inside a "pocket," as do GAF domains in more primitive creatures.

Humans have only a few kinds of GAF domains, all of which are in enzymes within the PDE family. They perform important functions not only in vision but also in hearts, lungs, and blood vessels. PDE5, an enzyme closely related to PDE6, is the therapeutic target for sildenafil, known by the trade name Viagra. In some men, this drug also inhibits PDE6 in the eyes, causing a temporary change in color vision.

More knowledge of the basic mechanisms of PDEs in vision may lead someday to better drug treatment for loss of eyesight from damaged retinas, such as occurs in night blindness and retinitis pigmentosa.


'/>"/>

Contact: Leila Gray
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Priming scientists for successful media interviews
2. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
3. Features of replication suggest viruses have common themes, vulnerabilities
4. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
5. Misconceptions about Alzheimers varies among races, survey suggests
6. Wasp genetics study suggests altruism evolved from maternal behavior
7. Yale discovery suggests protein may play a role in severe asthma
8. Study suggests link between obesity, poor bone health
9. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
10. Threatened birds may be rarer than geographic range maps suggest
11. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
(Date:5/20/2015)... , May 20, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the addition ... the Global Iris Recognition Market"  report ... , ,This research service analyses trends ... the government and commercial sectors, globally. ...
(Date:5/19/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
(Date:5/19/2015)... , May 19, 2015 ... announced the addition of the  "Genetic Testing ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, ... in-depth analysis of the current and future ... gene-based tests, their working principles and types ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Global Genetic Testing Market Outlook 2018 2
... UT Dallas researchers have demonstrated that treating tinnitus, or ringing ... and brought significant improvement to some of the participants in ... Kilgard of the School of Behavioral and Brain Sciences used ... tones to alleviate the symptoms of chronic tinnitus. Their results ...
... weapon in the battle against childhood obesity, says a new Cornell ... which found children not only ask for more food to fill ... "The quickest way parents can help kids eat less might be ... behavioral economics and the lead author. "Make it 12 ounces rather ...
... Huanglongbing (HLB) or citrus greening is a ... , and poses a serious threat to the citrus ... by disrupting the trees, food transportation systems. To ... that rapidly characterize citrus varieties and hybrids and locate ...
Cached Biology News:UT Dallas study: Initial success for new tinnitus treatment 2Geneticists receive funding to improve citrus production and health 2Geneticists receive funding to improve citrus production and health 3
(Date:6/3/2015)... Calif. , June 3, 2015 The ... life of myeloma patients while working toward prevention and ... Annual International Myeloma Working Group (IMWG) Summit June 8-10 ... 100-plus IMWG members will attend the 2015 Summit, which ... the European Hematology Association (EHA).  The focus of the ...
(Date:6/3/2015)... Longmeadow, Mass. (PRWEB) June 03, 2015 ... outsourced medical device manufacturing services for complex Class III ... to support a new UT Dallas-led initiative aimed at ... of Texas System institutions and moving them more ... CIRTEC has a long history of working with the ...
(Date:6/3/2015)... Tennessee (PRWEB) June 03, 2015 Green ... in Milan, Tennessee to support the RCBC Waste to ... is fourth generation in the family business, http://www.greenearthwaste.com ... 1908. His family added recycling to their waste ... and recycling services to the Fortune 500 companies with ...
(Date:6/3/2015)... 2015 The National Center for ... record by scaling CD-adapco’s flagship simulation tool STAR-CCM+® ... , STAR-CCM+ is a comprehensive multidisciplinary engineering ... innovation and lower product development costs. CD-adapco joined ... manufacturer Cray to push the code to new ...
Breaking Biology Technology:International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 2International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 3International Myeloma Foundation Brings Together 100 of the World's Top Myeloma Experts June 8-10 in Vienna, Austria for 6th Annual Summit 4CIRTEC Medical Systems to support new UT Dallas-led Initiative to deliver biomedical technologies from laboratory bench to bedside more efficiently 2NCSA Scales CD-adapco’s STAR-CCM+ to New World Record of 102,000 Cores on Blue Waters 2NCSA Scales CD-adapco’s STAR-CCM+ to New World Record of 102,000 Cores on Blue Waters 3
... in Clinical Chemistry- Complementary Market Positions and ... Global Opportunity, Increase Customer Choice ... Products into Olympus, Installed Chemistry Base Supports ... Accretive to Non-GAAP Earnings Per Share in ...
... 2008 Net Revenues - $30.1 million vs. $28.9 million in ... Income per Share - $0.11 vs. $0.10 in Q4 2007 ... vs. $39.2 million in Q4 2007 - a 15.1% increase2008 ... - a 34.9% increase2008 Diluted Net Income per Share of ...
... BRISBANE, Calif., Feb. 26 InterMune, Inc.,(Nasdaq: ITMN ... 12 months ended December 31, 2008. InterMune reported a ... or $0.83 per share, compared with a,net loss of $25.9 ... 2007. , Dan Welch, Chairman, Chief ...
Cached Biology Technology:Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 2Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 3Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 4Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 5Beckman Coulter to Acquire Lab-Based Diagnostics Business From Olympus Corporation 6ERT Reports Fourth Quarter and Full Year 2008 Results 2ERT Reports Fourth Quarter and Full Year 2008 Results 3ERT Reports Fourth Quarter and Full Year 2008 Results 4ERT Reports Fourth Quarter and Full Year 2008 Results 5ERT Reports Fourth Quarter and Full Year 2008 Results 6ERT Reports Fourth Quarter and Full Year 2008 Results 7ERT Reports Fourth Quarter and Full Year 2008 Results 8ERT Reports Fourth Quarter and Full Year 2008 Results 9ERT Reports Fourth Quarter and Full Year 2008 Results 10ERT Reports Fourth Quarter and Full Year 2008 Results 11InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 2InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 3InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 4InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 5InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 6InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 7InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 8InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 9InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 10InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 11InterMune Reports Fourth Quarter and Full Year 2008 Financial Results and Business Highlights 12
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
... Cy3 Ab Labeling Kit, 1 kit. ... with CyDye fluorescent dyes. Conjugations are ... complete within 1 h. Dyes are ... to ensure consistent labelings. Category: Blotting ...
Recombinant Human Erythropoietin (Tissue Culture Grade)...
Human PDGF R beta MAb (Clone # PR7212)...
Biology Products: