Navigation Links
Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
Date:10/7/2008

An atomic-resolution view of an enzyme found only in the eye has given researchers at the University of Washington (UW) clues about how this enzyme, essential to vision, is activated. The enzyme, phosphodiesterase 6 (PDE6), is central to the way light entering the retina is converted into a cascade of signals to the brain.

This particular form of the enzyme comes from the cone photoreceptors of the retina and has not been well-researched, in contrast to its rod form. Rods are involved in night vision and motion sensation; the cones are responsible for color sensitivity, visual acuity, daylight vision, and adjustment to bright light.

The section of the enzyme molecule that most interests the researchers is the so-called GAF A domain. A small messenger molecule, cGMP, binds to the GAF A domain to regulate the enzyme.

"The domain binds to this small molecule with extremely high sensitivity," said UW biochemist Clemens Heikaus, who along with Sergio E. Martinez, now a research associate at Rutgers, carried out the study. "From our structure, we can infer why it prefers cGMP over other messenger molecules." He added that the domain is quick in recognizing and responding to the messenger molecule to create an instantaneous flow of information to the brain.

Using X-ray crystallography and nuclear magnetic resonance, the researchers discovered that the enzyme undergoes major structural changes upon binding of the cGMP molecule.

Before binding occurs, the GAF domain is like an outstretched palm with the fingers wiggling, Heikaus said. After the cGMP molecule binds, the GAF domain closes and becomes less dynamic. In this state it looks more like a closed fist.

Further analysis of the consequences of this conformational change may lead to a better understanding of how the photoreceptor PDE helps regulate the path of signals that enable us to see, as well as provide general information on proteins with GA
'/>"/>

Contact: Leila Gray
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Priming scientists for successful media interviews
2. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
3. Features of replication suggest viruses have common themes, vulnerabilities
4. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
5. Misconceptions about Alzheimers varies among races, survey suggests
6. Wasp genetics study suggests altruism evolved from maternal behavior
7. Yale discovery suggests protein may play a role in severe asthma
8. Study suggests link between obesity, poor bone health
9. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
10. Threatened birds may be rarer than geographic range maps suggest
11. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions , ... entire spectrum of clinical research, is proud to announce ... company,s comprehensive SaaS-based eClinical technology platform, has led the ... first two quarters of 2015.   Q2 2015 and ... quarters measured by contract value sold in the company,s ...
(Date:8/10/2015)... Germany , August 10, 2015 /PRNewswire/ ... world leader in Eye Tracking Technology for more than ... Eye Tracking Platform for integration into all consumer display ... designs for seamless integration of eye tracking into consumer ... and augmented reality smart glasses. Omnivision,s leading sensor technology ...
(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... LOUISVILLE, Ky. -- By creating a unique system of ... tissue surrounding an implanted device, the longevity and function ... a study led by researchers in the University of ... was published early online on August 23, 2010 in ...
... that treatments targeting specific viral genes protected monkeys infected ... were protected even when therapeutics were administered one hour ... infections in laboratory or hospital settings. The research, ... Nature Medicine , was conducted by the U.S. ...
... Calif. Jodie Holt , a professor of plant ... consultant for James Cameron,s film Avatar , ... her life,s work as a distinguished scientist and educator" at ... the San Diego Botanic Garden, 230 Quail Gardens Drive, Encinitas, ...
Cached Biology News:New technology may prolong the life of implanted devices, from pacemakers to chemotherapy ports 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 3
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... ... customers’ weighing needs and expertly narrows down the product choices to a manageable ... criteria pares down the list to models that fit best with the customer’s ...
(Date:8/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, today announced that Paul ... Company Emerging Growth Conference on September 2 at 9:20am ... York Marriott Marquis. A live webcast ... relations section of Roka Bioscience,s website at http://rokabio.investorroom.com/ ...
(Date:8/26/2015)... BEIJING , August 26, 2015 ... DiaCardio wins 1 st place  Wayerz ... led in Israel by venture capital fund ... countries including the US, China , ... Latin America .  Impressive achievement for the Israeli ...
(Date:8/26/2015)... ... August 26, 2015 , ... The 2015 Epigenomics & Metabolomics ... technology start-up company Asymmetrex to share the first report on progress with ... biomarker for counting adult tissue stem cells. , With a name like “H2A.Z asymmetry,” ...
Breaking Biology Technology:METTLER TOLEDO Updates Online Scale Selection Tool 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... University of Pittsburgh-led team has created a single-electron ... more powerful computer memories, advanced electronic materials, and ... researchers report in Nature Nanotechnology that ... in diameteroperates with the addition of only one ...
... ImaginAb, Inc. and the University of California, Los Angeles ... fluorine chemistry for the rapid and robust labeling ... with Positron Emission Tomography (PET). ... and recognized the cutting-edge work being developed by the Crump ...
... Professor Andre Geim, a recipient of the 2010 Nobel Prize ... flow of electrons can magnetise graphene. The results, ... breakthrough in the field of spintronics. Spintronics is a ... the electron, in addition to its fundamental electric charge that ...
Cached Biology Technology:Pitt-led researchers create super-small transistor, artificial atom powered by single electrons 2ImaginAb, Inc. Concludes Licensing Agreement With UCLA for Novel Radiochemistry Technology 2New spin on graphene 2
... of gene expression) technology allows ... profiles generated by SAGE are ... transcripts making it possible to ... Kit is designed to make ...
... and flexibility press-to-seal silicone isolators can be ... researcher. They are available either pre-cut to ... that can be easily trimmed to prepare ... non-cytotoxic and can be used to isolate ...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
Alexa Fluor 350/488/594 Filter Set (Semrock Brightline) *mounted* *Zeiss Axio AF...
Biology Products: