Navigation Links
Atomic-level snapshot catches protein motor in action
Date:11/24/2009

The atomic-level action of a remarkable class of ring-shaped protein motors has been uncovered by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) using a state-of-the-art protein crystallography beamline at the Advanced Light Source (ALS). These protein motors play pivotal roles in gene expression and replication, and are vital to the survival of all biological cells, as well as infectious agents, such as the human papillomavirus, which has been linked to cervical cancer.

James Berger, a biochemist and structural biologist who holds joint appointments with Berkeley Lab's Physical Biosciences Division and University of California Berkeley's Department of Molecular and Cell Biology, and Nathan Thomsen, a graduate student in his research group, have captured a critical action shapshot of an enzyme known as the Rho transcription termination factor. In bacteria, the Rho motor protein binds to a specific region of messenger RNA and translocates along the chain to selectively terminate transcription at discrete points along the genome.

"We have shown that the Escherichia coli Rho transcription termination factor functions like a rotary engine, much like the motors found on certain classes of propeller airplanes," says Berger. "As the motor spins, fueled by the chemical energy in ATP nucleotides, it pulls RNA strands through it's interior, an action that enables Rho to walk along RNA chains. Interestingly, the rotary firing order of the motor is biased so that the Rho protein can walk in only one direction along the RNA chain."

Berger and Thomsen are the co-authors of a paper reporting the results this research that has been published in the journal Cell. The paper is titled: "Running in reverse: the structural basis for translocation polarity in hexameric helicases."

The Rho factor is a member of the hexameric helicase superfamily of enzymes - ring-shaped proteins made up of six independent subunits
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Purdue researchers obtain a snapshot clarifying how materials enter cells
2. Structural biology scores with protein snapshot
3. Protein chatter linked to cancer activation
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. Low levels of key protein may indicate pancreatic cancer risk
7. Structure of 450 million year old protein reveals evolutions steps
8. Scientists retrace evolution with first atomic structure of an ancient protein
9. Specific brain protein required for nerve cell connections to form and function
10. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Atomic-level snapshot catches protein motor in action
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)... SUNNYVALE, California , December 9, 2014 /PRNewswire/ ... Integrate with ITN,s BCARD Platform ... secure, cloud-based enterprise meeting scheduling solutions for business-to-business ... International, the world leader in mobile near-field communication ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... Chicago, November 23, 2010 Results of the world,s first ... or PrEP, were released online in the New England ... iPrEx, indicated an estimated 43.8% reduction of new HIV infections ... HIV, compared to those who took a placebo pill. ...
... how biological clocks adjust to having less sunlight in the winter ... shift work. Scientists studying the daily activity cycle in plants ... process that enables the plant,s genes to respond to the times ... of daylight in between. This system helps the plant to ...
... better tool to study how cells adhere to each other. ... stick together. Different kinds of cells have different kinds of ... focus on tens of thousands of them at a time ... but not on a single molecule. Sivasankar, an Iowa State ...
Cached Biology News:AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 2AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 3AIDS drug shown to prevent HIV in multinational trial of HIV-negative gay men 4Iowa State, Ames Lab researcher develops new way to study single biological molecules 2Iowa State, Ames Lab researcher develops new way to study single biological molecules 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Genta,Incorporated (OTC Bulletin Board: GNTA) today announced financial results,for the ... year, the,Company has recorded significant milestones including the following:, ... -- Oral G4544 for bone disease completes single dose-trial in ... -- leading oral taxane and new clinical-stage ...
... expanded cholesterol test can help clinicians identify best treatment ... options for patients at risk of heart disease, ... announced it will be exhibiting its VAP,Cholesterol Test in booth ... 2008, the premier scientific meeting for internal,medicine. The annual meeting ...
... SHENZHEN, China, May 7 /Xinhua-PRNewswire-FirstCall/ -- Mindray Medical,International Limited ... of medical devices in China with a rapidly growing ... the,first quarter ended March 31, 2008., Highlights ... net revenues were RMB626.0 million (US$89.3 million), ...
Cached Biology Technology:Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 2Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 3Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 4Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 5Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 6Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 7Genta Incorporated Announces First Quarter 2008 Financial Results and Corporate Highlights 8Atherotech to Exhibit the VAP Test at Internal Medicine 2008 2Mindray Medical International Announces First Quarter 2008 Results 2Mindray Medical International Announces First Quarter 2008 Results 3Mindray Medical International Announces First Quarter 2008 Results 4Mindray Medical International Announces First Quarter 2008 Results 5Mindray Medical International Announces First Quarter 2008 Results 6Mindray Medical International Announces First Quarter 2008 Results 7Mindray Medical International Announces First Quarter 2008 Results 8Mindray Medical International Announces First Quarter 2008 Results 9Mindray Medical International Announces First Quarter 2008 Results 10Mindray Medical International Announces First Quarter 2008 Results 11Mindray Medical International Announces First Quarter 2008 Results 12Mindray Medical International Announces First Quarter 2008 Results 13Mindray Medical International Announces First Quarter 2008 Results 14Mindray Medical International Announces First Quarter 2008 Results 15Mindray Medical International Announces First Quarter 2008 Results 16Mindray Medical International Announces First Quarter 2008 Results 17Mindray Medical International Announces First Quarter 2008 Results 18
... 5 ml of DETACHaBEAD 19 polyclonal ... CD19 (Pan B). B cells ... and released with DETACHaBEAD CD19 are ... suitable for applications such as culturing ...
This Malachite Green Phosphate Detection Kit...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
...
Biology Products: