Navigation Links
Atlas of an organism
Date:1/18/2011

While every cell of an organism contains the same genes only a proportion are expressed in any tissue at a given stage in development. Knowing the extent of gene transcription is valuable and a team of European researchers has generated an atlas of gene expression for the developing mouse embryo. This will be a powerful resource to determine co-expression of genes and to identify functional associations between genes relevant to development and disease. The findings will be published next week in the online, open access journal PLoS Biology.

The comprehensive, interactive and freely accessible digital gene expression atlas (www.eurexpress.org) includes expression data for over 15,000 genes in hundreds of anatomical structures and led to the identification of tissue-specific and tissue-overlapping gene networks. For instance the data revealed new information for several developing structures, such as the telencephalon, a novel organization for the hypothalamus and insight on the signaling pathways involved in renal epithelial differentiation during kidney development.

The project involved researchers from 12 different European institutions, from 6 different countries (Italy, Spain, United Kingdom, Germany, France and Switzerland).

"This work was only possible due to the close collaboration of all scientists involved and nicely illustrates the success a coordinated and collaborative effort can achieve. The gene expression atlas will be an important guide to discover gene function and disease mechanisms." says Professor Andrea Ballabio, the coordinator of the study from the Telethon Institute of Genetics and Medicine, Naples, Italy.

"The size of the task required a team of specialists whose combination of different expertise was needed to achieve an output that is greater than the sum of the parts; the freely available data and the impressive images will be of great help to all researchers working on the function of the genome and the molecular causes of the myriads of genetic disorders" says Professor Stylianos Antonarakis, one of the collaborators of this study at the University of Geneva.


'/>"/>

Contact: Dr. Andrea Ballabio
ballabio@tigem.it
Public Library of Science
Source:Eurekalert

Related biology news :

1. Allen Institute for Brain Science launches Allen Human Brain Atlas
2. Environmental Atlas of Europe unveiled at COP15
3. Penguins and sea lions help produce new atlas
4. UNC awarded Cancer Genome Atlas grant
5. 3-D kidney atlas created for researchers and physicians
6. Human protein atlas will help pinpoint disease
7. LCD projector used to control brain and muscles of tiny organisms such as worms
8. Swimming microorganisms stir things up, and the LHC takes over
9. Traveling microorganisms
10. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
11. Understanding robustness in organisms -- a potential weapon against infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
(Date:6/2/2016)... -- The Department of Transport Management (DOTM) of ... US Dollar project, for the , Supply and ... and IT Infrastructure , to Decatur ... of Identity Management Solutions. Numerous renowned international vendors participated in ... was selected for the most compliant and innovative solution. ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Liquid Biotech ... funding of a Sponsored Research Agreement with The ... cells (CTCs) from cancer patients.  The funding will ... levels correlate with clinical outcomes in cancer patients ... will then be employed to support the design ...
(Date:6/24/2016)... ... 2016 , ... While the majority of commercial spectrophotometers and fluorometers use the ... models are higher end machines that use the more unconventional z-dimension of 20mm. ... the bottom of the cuvette holder. , FireflySci has developed several Agilent flow ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
Breaking Biology Technology: