Navigation Links
Atlas of an organism
Date:1/18/2011

While every cell of an organism contains the same genes only a proportion are expressed in any tissue at a given stage in development. Knowing the extent of gene transcription is valuable and a team of European researchers has generated an atlas of gene expression for the developing mouse embryo. This will be a powerful resource to determine co-expression of genes and to identify functional associations between genes relevant to development and disease. The findings will be published next week in the online, open access journal PLoS Biology.

The comprehensive, interactive and freely accessible digital gene expression atlas (www.eurexpress.org) includes expression data for over 15,000 genes in hundreds of anatomical structures and led to the identification of tissue-specific and tissue-overlapping gene networks. For instance the data revealed new information for several developing structures, such as the telencephalon, a novel organization for the hypothalamus and insight on the signaling pathways involved in renal epithelial differentiation during kidney development.

The project involved researchers from 12 different European institutions, from 6 different countries (Italy, Spain, United Kingdom, Germany, France and Switzerland).

"This work was only possible due to the close collaboration of all scientists involved and nicely illustrates the success a coordinated and collaborative effort can achieve. The gene expression atlas will be an important guide to discover gene function and disease mechanisms." says Professor Andrea Ballabio, the coordinator of the study from the Telethon Institute of Genetics and Medicine, Naples, Italy.

"The size of the task required a team of specialists whose combination of different expertise was needed to achieve an output that is greater than the sum of the parts; the freely available data and the impressive images will be of great help to all researchers working on the function of the genome and the molecular causes of the myriads of genetic disorders" says Professor Stylianos Antonarakis, one of the collaborators of this study at the University of Geneva.


'/>"/>

Contact: Dr. Andrea Ballabio
ballabio@tigem.it
Public Library of Science
Source:Eurekalert

Related biology news :

1. Allen Institute for Brain Science launches Allen Human Brain Atlas
2. Environmental Atlas of Europe unveiled at COP15
3. Penguins and sea lions help produce new atlas
4. UNC awarded Cancer Genome Atlas grant
5. 3-D kidney atlas created for researchers and physicians
6. Human protein atlas will help pinpoint disease
7. LCD projector used to control brain and muscles of tiny organisms such as worms
8. Swimming microorganisms stir things up, and the LHC takes over
9. Traveling microorganisms
10. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
11. Understanding robustness in organisms -- a potential weapon against infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , ... June 23, 2016 , ... In a new ... in Denmark detail how a patient who developed lymphedema after being treated for breast ... results could change the paradigm for dealing with this debilitating, frequent side effect of ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
Breaking Biology Technology: