Navigation Links
At the crossroads of chromosomes
Date:9/17/2010

PHILADELPHIA On average, one hundred billion cells in the human body divide over the course of a day. Most of the time the body gets it right but sometimes, problems in cell replication can lead to abnormalities in chromosomes resulting in many types of disorders, from cancer to Down Syndrome.

Now, researchers at the University of Pennsylvania's School of Medicine have defined the structure of a key molecule that plays a central role in how DNA is duplicated and then moved correctly and equally into two daughter cells to produce two exact copies of the mother cell. Without this molecule, entire chromosomes could be lost during cell division.

Ben Black, PhD, assistant professor of Biochemistry and Biophysics, and Nikolina Sekulic, PhD, a postdoctoral fellow in the Black lab, report in the September 16 issue of Nature the structure of the CENP-A molecule, which defines a part of the chromosome called the centromere. This is a constricted area to which specialized molecules called spindle fibers attach that help pull daughter cells apart during cell division.

"Our work gives us the first high-resolution view of the molecules that control genetic inheritance at cell division," says Black. "This is a big step forward in a puzzle that biologists have been chipping away at for over 150 years."

Investigators have known for the last 15 years that part of cell division is controlled by epigenetic processes, the series of actions that affect the protein spools around which DNA is tightly bound, rather than encoded in the DNA sequence itself. Those spools are built of histone proteins, and chemical changes to these spool proteins can either loosen or tighten their interaction with DNA. Epigenetics alter the readout of the genetic code, in some cases ramping a gene's expression up or down. In the case of the centromere, it marks the site where spindle fibers attach independently of the underlying DNA sequence. CENP-A has bee
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
2. Tumor suppressor p53 prevents cancer progression in cells with missegregated chromosomes
3. Longevity tied to genes that preserve tips of chromosomes
4. Genetic conflict in fish led to evolution of new sex chromosomes
5. UGA researchers propose model for disorders caused by improper transmission of chromosomes
6. Female human embryos adjust the balance of X chromosomes before implantation
7. Slicing chromosomes leads to new insights into cell division
8. Evolutionary origin of bacterial chromosomes revealed
9. How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
10. Keeping chromosomes from cuddling up
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
At the crossroads of chromosomes
(Date:4/27/2015)... , Apr. 27, 2015 Profile Solutions, ... control and security systems is pleased to announce that ... as a consultant and member of its scientific advisory ... widely known as a thought leader in technology-enhanced learning ... Technology Group, and has published studies and books focused ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... to synchronize the pitch of their calls with an extremely high ... call to call, according to a new study of the blue ... the Journal of the Acoustical Society of America . The ... could allow individual whales to locate potential mates by swimming toward ...
... bowel syndrome has been traced to a small piece of ... to hostile conditions that can produce diarrhea, bloating and chronic ... sends signals that stop the activity of the gene that ... shortage of glutamine in the gut with the seepage of ...
... that could lead to new drugs that reduce the ... in the August 2010 issue of Journal of ... with the function of the cell membrane protein called ... relevant model of severe infection. "Clinical trials ...
Cached Biology News:Blue whales align the pitch of their songs with extreme accuracy, study finds 2Scientists target possible cause of 1 form of bowel disease 2Scientists target possible cause of 1 form of bowel disease 3
(Date:5/21/2015)... Worms, Germany (PRWEB) May 21, 2015 ... announces that its manufacturing facility in Worms, Germany ... EXCiPACT™, an independent subsidiary of the International Pharmaceutical ... three Grace facilities that produce its SYLOID® FP ... now received GMP certification, following the Curtis Bay, ...
(Date:5/21/2015)... LOS ANGELES , May 21, 2015 /PRNewswire/ ... research and development company specializing in oncology, today ... 2 clinical trial with aldoxorubicin for the treatment ... of brain cancer.  The open-label, multisite trial is ... of aldoxorubicin in patients whose tumors have progressed ...
(Date:5/21/2015)... 20, 2015 Research and Markets ... the "2015 Global Survey on Flow Cytometry ... The primary goal of this research is ... and reagents. Key information the survey seeks to ... flow cytometers, predominantly used applications for flow cytometers, ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
Breaking Biology Technology:Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Global Survey on Flow Cytometry Adoption Trends 2015 2Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2
... ... ... today announced it has made two cotton acquisitions in India to enhance its product lineup ... the cotton seed business of Nandi Seeds, based in Mehboob Nagar, Andhra Pradesh, India, and ...
... Del. and MONHEIM, Germany, June 25 DuPont (NYSE: ... into a series of long-term business agreements related to ... help increase agricultural productivity around the world. , ... for both parties through herbicide and seed sales as ...
... Qforma, an advanced analytics and predictive modeling ... and field operations positions: Mark J. Grove is appointed Senior ... Qforma from Director, Field Operations to Vice President, Sales and ... Directors, Field Operations. , , These appointments follow a ...
Cached Biology Technology:DuPont Adds Cotton to India Seed Product Lineup 2DuPont Adds Cotton to India Seed Product Lineup 3DuPont Adds Cotton to India Seed Product Lineup 4DuPont and Bayer CropScience Expand Collaboration With Broad License Agreements 2DuPont and Bayer CropScience Expand Collaboration With Broad License Agreements 3DuPont and Bayer CropScience Expand Collaboration With Broad License Agreements 4Qforma Appoints Four Executives in Sales and Field Operations 2Qforma Appoints Four Executives in Sales and Field Operations 3
... the proven features of the pET, BacVector ... all of the benefits and versatility of ... The pTriEx vectors have been extensively tested ... all three expression systems. In each case, ...
Rabbit polyclonal to Shigella Immunogen: Mixture of S. boydii, S. flexneri & S. dysenteriae....
... ALDEFLUOR Stem Cell Identification ... comprises a substrate for ... (ALDH) that is highly ... stem cells, making ALDH ...
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
Biology Products: