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Astronomy technology brings nanoparticle probes into sharper focus
Date:2/19/2008

wded fields of stars.

After adapting DAOPHOT, the research team used color-coded nanoparticles to beat the traditional diffraction limit by nearly two orders of magnitude, allowing routine super-resolution imaging at one nanometer resolution. And by using DNA molecules, two color-coded nanoparticles are designed to recognize two binding sites on a single target. Then the particles are brought together within nanometer distances after target binding.

These distances are sorted out by highly efficient image processing technology, leading to detection and identification of individual molecules based on the targets geometric size.

Compared to other single molecule imaging methods, the Georgia Tech and Emory system allows for higher-speed detection involving much larger sample volumes (microliter to milliliters).


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Contact: Megan McRainey
megan.mcrainey@comm.gatech.edu
404-894-6016
Georgia Institute of Technology
Source:Eurekalert

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