Navigation Links
Asthma drug could help control or treat Alzheimer's disease
Date:3/25/2011

A drug used to treat asthma has been shown to help reduce the formation of amyloid beta, a peptide in the brain that is implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine.

The researchers published their findings, "Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an AD Transgenic Mouse Model," in the American Journal of Pathology.

In previous studies, the Temple researchers discovered that 5-lipoxygenase, an enzyme long known to exist in the brain, controls the activation state of gamma secretase, another enzyme that is necessary and responsible for the final production of amyloid beta. When produced in excess, amyloid beta causes neuronal death and forms plaques in the brain. The amount of these amyloid plaques in the brain is used as a measurement of the severity of Alzheimer's.

In their current study, led by Domenico Pratic, an associate professor of pharmacology in Temple's School of Medicine, the researchers tested the drug Zileuton, an inhibitor of 5-lipoxygenase typically used to treat asthma, in a transgenic mouse model of Alzheimer's disease. At the end of the treatment they found that this drug, by blocking the 5-lipoxygenase, reduced gamma secretase's production of amyloid beta and the subsequent build up of amyloid plaques in the brain by more than 50 percent.

Pratic said that gamma secretase is present throughout the body and, despite its role in the development of amyloid plaques, plays a significant role in numerous important functions. Direct inhibitors of gamma secretase are known, he said, but blocking the enzyme completely may cause problems such as the development of cancer. Unlike classical gamma secretase inhibitors, Zileuton only modulates the protein expression levels, which keeps some of its vital functions in tact while blocking many of its bad effects, which in this case is the development of
'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Asthma tied to bacterial communities in the airway
2. Family mealtimes play a role in health of children with asthma
3. More research needed on diet and environmental influences on childhood asthma
4. Young people with asthma run a greater risk of developing caries
5. New asthma research breaks the mold
6. Discovery of taste receptors in the lungs could help people with asthma breathe easier
7. Possible alternate therapy for adults with poorly controlled asthma
8. Research and insights on severe asthma in children
9. Study points to key genetic driver of severe allergic asthma
10. Asthma and eczema sufferers have a lower risk of developing a cancer
11. Ultrafine particles in air pollution may heighten allergic inflammation in asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... 2014) Emerging fungal pathogens pose a greater ... causing population declines of amphibians, bats, corals, bees ... South Florida published in the prestigious journal ... or immunological resistance to a deadly chytrid fungus ... "Acquired resistance is important because it is the ...
(Date:7/9/2014)... critically ill children with traumatic injuries have identified ... likely to develop a hospital-acquired infection. The study, ... published online in June in the journal ... that could lead to the clinical implementation of ... or reverse immune system damage following critical illness ...
(Date:7/9/2014)... about the prevalence of antibiotic-resistant illness, Case Western ... to disabling disease: blocking bacteria,s access to iron ... bacterial siderophore, a small molecule, captures iron from ... as well as how the body launches ... findings appear in a recent edition of ...
Breaking Biology News(10 mins):USF study: Amphibians can acquire resistance to deadly fungus 2Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Bacteria hijack plentiful iron supply source to flourish 2
... engineers, led by the University of Alberta and the ... $3.39 million, three-year study to assess the potential effects ... "Nanotechnology is a very new and quickly developing field. ... solid scientific data upon which to base their regulatory ...
... In a discovery that rebuffs conventional scientific thinking, ... a novel way to block the activity of the ... found in children and young adults. In the ... , they report discovering and successfully testing a small ...
... 2009 Researchers at Ben-Gurion University of the Negev (BGU) ... may increase the possibility for diseases, including cancer., The findings ... Research ., The team of researchers from BGU,s National Institute ... for mutations in the genome of the mitochondria, a part ...
Cached Biology News:Canadian researchers set to study impact of nanomaterials on aquatic ecosystems 2GUMC discovery highlights new direction for drug discovery 2GUMC discovery highlights new direction for drug discovery 3Ben-Gurion U. researchers reveal connection between cancer and human evolution 2
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... made as distribution channel reorders,continue, FREDERICK, ... maker of ActiPatch(R) Therapy, the drug free ... delivering continuous pulse,therapy that revolutionizes the way ... distribution penetration into the Canadian market.,ActiPatch Therapy ...
... Consultancy for Emerging Chinese Companies, HAIKOU CITY, ... Inc. ("China Pharma") (OTC Bulletin Board: CPHI),which develops, ... China, today announced the appointment of,The Ruth Group ... Zhilin Li, President and CEO of China Pharma ...
... BURLINGAME, Calif., Oct. 21 Sensorin, which ... measurement,platform for bioprocess applications, today announced the ... Use of proceeds from the financing includes,product ... proprietary pH,sensing system. Terms of the financing ...
Cached Biology Technology:BioElectronics Announces Significant Progress in Canadian and International Distribution 2China Pharma Holdings, Inc. Appoints The Ruth Group 2China Pharma Holdings, Inc. Appoints The Ruth Group 3Sensorin Raises Equity Financing to Launch Novel Industrial Sensing Venture 2
propidium iodide *1.0 mg/mL solution in water*...
1 unit is sufficient for 1 caspase activity assay....
Applications: (+) Immunocytochemistry and immunohistochemistry...
Anti-Rat KAPPA/LAMBDA:HRP, Clone MARK-1/MARL-15, Monoclonal Antibody...
Biology Products: