Navigation Links
Asthma and other allergies tied to absence of specialized cells
Date:7/17/2008

osure to the same allergenin this case egg proteindid not elicit an allergic response in mice that were able to make Treg cells. The findings are reported in the July 18, 2008, issue of the journal Immunity.

The formation of Foxp3-positive Treg cells occurs in response to any potential allergen, so the findings are applicable to a broad range of allergic reactions and autoimmune diseases, says Dr. de Lafaille. When people suffer from allergies, including life-threatening ones such as asthma, something goes wrong in the process by which Foxp3 signals Treg cell formation. The problem is not necessarily a mutation in the Foxp3 gene, which is known to cause severe autoimmune disease. Rather, something occurs, or fails to occur, in the lungs or the gut that interferes with the production or activity of allergen-specific Treg cells.

The NYU researchers also determined that Treg cells control damage from long-term inflammation. They found high concentrations of Treg cells in inflamed lung tissue of mice without the Foxp3 defect. "The question arose about what these cells are doing in the tissueare they beneficial or not?" Dr. de Lafaille says. It turns out that even though the Treg cells did not prevent inflammation in an ongoing allergic reaction, they kept it under control, ensuring it did not worsen or spread to other areas of the body. "We think that over time these regulatory T cells become more important than the inflammatory cells and end up completely shutting off the inflammation. But it's not overnight and it's not black and white," Dr. de Lafaille emphasizes.

This finding provides a key to one of the most serious consequences of asthma. In addition to breathing problems during an acute attack, people with asthma have chronic inflammation, which can permanently damage their airways. If a means could be found to increase the number of Treg cells in inflamed tissue, this might be prevented. Allergic asthma, the most common and best-u
'/>"/>

Contact: Lorinda Klein
lorindaann.klein@nyumc.org
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Consumption of nut products during pregnancy linked to increased asthma in children
2. For some who have lost their sense of smell, a once popular asthma drug could help
3. Increased allergen levels in homes linked to asthma
4. Severe asthma may be a different form of the disease
5. HATS off to combat asthma
6. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
7. Yale discovery suggests protein may play a role in severe asthma
8. Study finds a high rate of asthma in college athletes
9. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
10. Smothered genes combine with mutations to yield poor outcome in cancer patients
11. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... marine food chain, albatrosses accumulate toxic contaminants such as ... study has found dramatic differences in contaminant levels between ... areas of the North Pacific. Researchers also found that ... species over the past ten years. , The differences ...
... State University professor Dr. Patrick D. Lorch, have revealed ... Mormon crickets in western North America. , ... a fear of cannibalism, drives the mass migration of ... their seasonal migration, millions of Mormon crickets (relatives of ...
... of years ago, humans began scrubbing off and discarding ... white kernel beneath. Now, for the first time, scientists ... rice processing, called rice bran, significantly lowers blood pressure ... The team reports their findings in the March 8 ...
Cached Biology News:Vegetables inhibit growth of prostate cancer in mice with human tumors 2Vegetables inhibit growth of prostate cancer in mice with human tumors 3How nice, brown rice: Study shows rice bran lowers blood pressure in rats 2
(Date:5/21/2015)... Research and Markets ( http://www.researchandmarkets.com/research/84975r/2015_global ... "2015 Global Survey on Flow Cytometry Adoption Trends" ... primary goal of this research is to analyze ... Key information the survey seeks to collect include ... predominantly used applications for flow cytometers, respondents, most ...
(Date:5/20/2015)... May 20, 2015 Research and Markets ... "Top Technologies in HW_Technical Insights" report to ... report evaluated technology trends in the Health and Wellness ... likely to have an impact in the year 2015. ... the top 10 health and wellness technologies that are ...
(Date:5/20/2015)... May 20, 2015  Health eCareers, the healthcare ... organizations with job seekers looking for the flexibility ... new mobile and online tool dedicated exclusively to ... SHIFT enables employers to quickly find ... nursing, per diem and other temporary positions, eliminating ...
(Date:5/20/2015)... , May 20, 2015  Resolution Bioscience announced ... ctDx ALK TM , a blood-based liquid biopsy ... cell lung carcinoma (NSCLC), the most common form of ... test to guide patients to personalized therapies and direct ... The Department of Health, the CLIA authority ...
Breaking Biology Technology:Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3Resolution Bioscience Receives CLIA Certification for its Diagnostic Laboratory and Launches CLIA-Certified Liquid Biopsy for Lung Cancer 2
... LOUIS, June 5 /PRNewswire-FirstCall/ -- Express Scripts, ... at the William Blair Growth Stock Conference on Thursday, June 11, ... Chicago. , , This presentation will also be broadcast ... section of Express Scripts web site at http://www.express-scripts.com ...
... , For the second time in three years, ... recognized American Biotech Labs(R) as Utah,s top, company ... UT, June 4 /PRNewswire/ - American Biotech Labs, LLC (ABL), developer ... nano-catalytic SilverSol Technology(R), today announced that the company has won the ...
... (Nasdaq: ARNA ) announced today that the ... Sciences Conference on June 11, 2009 at 11:00 a.m. Eastern Time ... Hotel in New York City. Robert E. Hoffman, Arena,s Vice President, ... of the company, including its clinical development and research programs. , ...
Cached Biology Technology:Express Scripts to Present at William Blair Growth Stock Conference 2American Biotech Labs(R) Garners 2009 Utah Best of State Award 2American Biotech Labs(R) Garners 2009 Utah Best of State Award 3Arena Pharmaceuticals to Present at the 8th Annual Needham Life Sciences Conference 2Arena Pharmaceuticals to Present at the 8th Annual Needham Life Sciences Conference 3
Mouse monoclonal antibody raised against a partial recombinant MYO7A. NCBI Entrez Gene ID = MYO7A...
... Lines ,High Quality, Functionally-Validated, Ion Channel Cell ... for having a critical role in nerve ... key function in pain, CNS and the ... been investigated in therapeutic areas, such as ...
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Biology Products: