Navigation Links
Asthma and other allergies tied to absence of specialized cells
Date:7/17/2008

NEW YORK July, 16, 2008 When it comes to allergies, both the problem and the solution are found within us. Our immune systems respond to foreign substances with an arsenal of cells. Some are programmed to "remember" invaders they've encountered in the past. Normally, anything previously identified as harmless is allowed to pass. Sometimes, however, the immune response goes awry, triggering an allergic reaction.

Now, researchers at NYU School of Medicine have zeroed in on a class of custom-made immune cells that block allergic reactions. These regulatory T cells are manufactured according to instructions from a gene called Foxp3 whenever we eat or inhale a potential allergen for the first time, ensuring that the next time we encounter that substance, we will not mount an allergic response.

"We don't become allergic to lots of thingswe eat all kinds of things, we breathe all kinds of things, and what prevents us from developing allergies is that we make regulatory T cells, which specifically recognize this allergen," says Maria A. Curotto de Lafaille, Ph.D., Associate Research Scientist at NYU Langone Medical Center. "Every time we don't react to something or don't become allergic, it's not because nothing is happening," Dr. de Lafaille explains. "It's because something very important is happening: We're making these cells,"

Mucosal tissue, which lines both the respiratory and digestive tracts, has long been known as an effective barrier against allergens, which are always protein molecules. The NYU research shows that Foxp3-directed regulatory T cells (Treg) are produced in the mucosal tissue and remain there to prevent allergic reactions. New ones are tailor-made every time an unknown protein is inhaled or ingested. The inability to make Treg cells results in high susceptibility to becoming allergic.

The NYU researchers induced allergic reactions in mice with a Foxp3 mutation that prevented formation of Treg cells. Exp
'/>"/>

Contact: Lorinda Klein
lorindaann.klein@nyumc.org
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Consumption of nut products during pregnancy linked to increased asthma in children
2. For some who have lost their sense of smell, a once popular asthma drug could help
3. Increased allergen levels in homes linked to asthma
4. Severe asthma may be a different form of the disease
5. HATS off to combat asthma
6. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
7. Yale discovery suggests protein may play a role in severe asthma
8. Study finds a high rate of asthma in college athletes
9. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
10. Smothered genes combine with mutations to yield poor outcome in cancer patients
11. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... tropical rainforest teeming with life it,s not what comes ... the first time evidence of Doncaster,s 310-million-year-old past, including a ... mining tip. , Some of the fossilised plants and creatures ... the egg case, several horseshoe crabs and some previously unrecorded ... preserved in rocks that formed within the coal and shale ...
(Date:9/15/2014)... , , , ... , , , , ... own set of symptoms. The finding could be a first... , , ... , , , , ... , , , , , , , New research shows that schizophrenia ...
(Date:9/15/2014)... SANTA BARBARA, Calif. , Sept. 15, 2014 ... Goleta, California , announces the public ... has a very unique, patented product, combining room ... GENiSYSS is the only company to make personal ... Photo - http://photos.prnewswire.com/prnh/20140912/145664   Photo ...
Breaking Biology News(10 mins):'Jaws' lived in Doncaster 2Schizophrenia not a single disease but multiple genetically distinct disorders 2Schizophrenia not a single disease but multiple genetically distinct disorders 3Schizophrenia not a single disease but multiple genetically distinct disorders 4Schizophrenia not a single disease but multiple genetically distinct disorders 5GENiSYSS Launches Website about Easy, Inexpensive Home DNA Storage for Everyone 2
... Scientists at Barrow Neurological Institute have recently made discoveries about ... central nervous system (CNS) a finding that could have ... multiple sclerosis. The research, led by Barrow,s Fu-Dong Shi, MD, ... Journal of Experimental Medicine , and simultaneously highlighted in ...
... The availability of highly nutritious forage is one of ... in western Oregon and Washington, according to a modeling ... Service,s Pacific Northwest (PNW) Research Station. Findings from the ... planning for the ecologically and economically important ungulate in ...
... Researchers at the Swedish medical university Karolinska Institutet have been ... receptor that binds sperm at the beginning of fertilization. The ... to better understanding of infertility and may enable entirely new ... has been grasped by the encounter of gametes egg ...
Cached Biology News:Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington 2
(Date:9/15/2014)... Sept. 15, 2014  FlexTech Alliance today issued ... printed product demonstrators (demos) and a functional electronic ... with pre-proposals due on October 22, 2014 and ... proposals ultimately selected are provided by the US ... cost share by the proposing organization. ...
(Date:9/15/2014)... The very idea of fibers made of carbon nanotubes is ... literally. , The single-walled carbon nanotubes in new fibers created ... through a process designed by chemist Angel Mart and his ... reported its results this month in the journal ACS ... they,re drawn together into a fiber. , Left to their ...
(Date:9/15/2014)... , Sept. 15, 2014 Zymo Research ... transport solution for safe ambient temperature storage and ... testing. Importantly, the infectivity of agents in such samples ... the integrity of the viral nucleic acids for ... recent Ebola epidemic in West Africa ...
(Date:9/15/2014)... Texas , Sept. 15, 2014 The chemistry, ... in climate, says a new article published by the nonprofit ... , PhD, on climate change and its effects on the ... of an extensive study conducted by Dr. Ahmed in the ... China and has implications for the future of ...
Breaking Biology Technology:FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4
... is now licensed to supply ISBT 128-compliant label,design and printing software ... ... and laboratories, MILWAUKEE, Aug. 28 Niceware(R) International, LLC is,excited ... to provide ISBT 128-compliant blood bag labeling,software solutions that support ISBT ...
... August 28 XTL Biopharmaceuticals,Ltd. (NASDAQ: XTLB ... in the acquisition, development and commercialization of,therapeutics for ... and hepatitis C, today announced the receipt on ... indicating that, according to the,Company,s financial statements for ...
... its ADR Listing to the NASDAQ Capital Market, ... (NASDAQ: XTLB ; LSE: XTL; TASE: XTL), ... commercialization of,therapeutics for the treatment of unmet medical ... the receipt on August 23,2007, of a NASDAQ ...
Cached Biology Technology:Niceware International Announces Licensed Vendor Status with ICCBBA, Inc. to Provide ISBT 128-compliant Software 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 3XTL Receives Staff Letter From NASDAQ 2XTL Receives Staff Letter From NASDAQ 3
... iLink makes it easy to supply microplates, ... Developed with operator convenience in mind, iLink ... ease of use. The iLink software is ... assays or sub-assays, that can be copied ...
... integrated digital microscope and camera system that ... optical adjustment or software installation. Built on ... combines simplicity and advanced technology for users ... viewing of a macro image and a ...
... DASGIP Overhead Drive for individual and ... for flexible agitation of DASGIP vessels, featuring ... impellers. ,Up to 16 overhead drives ... DASGIP Cultivation Systems fedbatch-pro® and cellferm-pro® for ...
This kit is designed to select cells labeled with biotinylated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
Biology Products: