Navigation Links
Asterix's Roman foes -- Researchers have a better idea of how cancer cells move and grow
Date:3/11/2013

This press release is available in French.

Researchers at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) have discovered a new mechanism that allows some cells in our body to move together, in some ways like the tortoise formation used by Roman soldiers depicted in the Asterix series. Collective cell migration is an essential part of our body's growth and defense system, but it is also used by cancerous cells to disseminate efficiently in the body. "We have found a key mechanism that allows cells to coordinate their movement as a group and we believe that this mechanism is used by malignant cells in a number of cancers, including some types of breast, prostate and skin cancers" explained lead researcher Gregory Emery. Roman soldiers formed the tortoise, or testudo formation, by coming closely together and aligning their shields side-by-side in order to defend themselves as they broke their enemy lines.

"As for the Romans, if some cancerous cells are migrating efficiently, it is because their movements are tightly coordinated. To stop their progression, we have first to understand how they coordinate. Then, we will aim at blocking this coordination in cancer cells to abrogate cancer progression."

IRIC's scientists and their colleagues from the Johns Hopkins School of Medicine in Baltimore, USA studied the movement of the "border-cells" in the ovaries of fruit flies, a biological process that is well understood by scientists and that they can reproduce easily. Researchers often use these kinds of cells as a model to get insight into metastatic cell migration the process by which malignant cells leave the original tumor as they can be easily manipulated and observed. Researchers look at how chemicals known as proteins that our body produces influence what goes on in cells. In this study for instance, the researchers from IRIC were able to aim a laser with sufficient precision to activate or inactivate an engineered protein in a single living cell, and observe directly the consequences of these alterations.

They found that a protein known as Rab11 enables individual cells to sense what the others are doing and organize into a tight structure to move together. Rab11 achieves this by regulating another protein, called Moesin which is involved in controlling the shape and rigidity of cells. Reducing the level of Moesin reduces the cohesion of the cluster and impedes cell movement. "Here, we have identified a mechanism by which the cells share information to coordinate movements. By disrupting this mechanism, we are able to block their migration." Dr Emery explained.

Although the findings were in a specific kind of cells in an insect model, the proteins involved, Rab11 and Moesin, have already been shown to play a role in some human cancers. "This indicates that the new regulatory mechanism we identified in fly cells is most likely also important in human cancers," Dr. Emery said. "Our work will allow us to identify molecular targets to disrupt collective cell migration and hopefully to fight metastasis formation" he concludes.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert  

Related biology news :

1. The worlds most sensitive plasmon resonance sensor inspired by ancient Roman cup
2. Valentines Day tales of romance and chemistry
3. Ovarian tumor, with teeth and a bone fragment inside, found in a Roman-age skeleton
4. Impulsive micromanagers help plants to adapt, survive
5. Romancing the firefly
6. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
7. Researchers develop tools for discovering new species
8. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
9. IRB Barcelona researchers discover mechanism that regulates steroid hormone production in Drosophila
10. Researchers discover gateway in nucleus has a second important job no one noticed before
11. Researchers explain a key developmental mechanism for the first time in plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Asterix's Roman foes -- Researchers have a better idea of how cancer cells move and grow
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... (PRWEB) , ... June 19, 2017 , ... A colony ... among its cells and tissues by delivering pollen and nectar containing nutrients necessary for ... means to stay healthy. , Many recent indicators point to a decline in honey ...
(Date:6/16/2017)... Hill, CT (PRWEB) , ... June 16, 2017 , ... ... last night’s Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers in ... innovative project ideas to a panel of judges for an opportunity to secure $10,000 ...
(Date:6/15/2017)... PA (PRWEB) , ... June 15, 2017 , ... ... Esther Klein Gallery (EKG) follows an artist’s journey through creative experimentation and interdisciplinary ... 2017 and runs through July 22nd. An opening reception will be held at ...
(Date:6/15/2017)... ... June 15, 2017 , ... Adam ... on how to assemble a lab workstation. The guide outlines the procedure in ... Nimbus or Eclipse balance, AVT anti-vibration table, OIML/ASTM certified weights, and Adam DU ...
Breaking Biology Technology: