Navigation Links
Association between menopause, obesity and cognitive impairment
Date:10/13/2011

Bethesda, Md. Obesity has been associated with cognitive decline, characterized by a deterioration of mental abilities that involve memory, language, and thought-processing speed. But in a study of 300 post-menopausal women included in the Cardiovascular Prevention Program "Corazn Sano," in Argentina, obese participants in the study performed better on three cognitive tests than participants of normal weight, leading researchers to speculate about the role of sex hormones and cognition.

According to the study's lead author, Judith M. Zilberman, MD, of the School of Pharmacy and Biochemistry's Department of Physiology, and the Instituto Cardiovascular de Buenos Aires, Argentina, these results may be attributable to estrogen stored and released by fat cells. Dr. Zilberman will discuss her team's findings at the Physiology of Cardiovascular Disease: Gender Disparities conference, October 12 at the University of Mississippi in Jackson. The conference is sponsored by the American Physiological Society with additional support from the American Heart Association. Her presentation is entitled, "Association Between Menopause, Obesity, and Cognitive Impairment."

The Study

The researchers reviewed the records of 678 women who had participated in Villa Mara, Crdoba. Of this number, 300 (44.3 percent) were identified as having been post-menopausal for at least 1 year. Of these, 158 women (52.6 percent) were also classified as obese either because of their waist circumference or body mass index (BMI). The average of the women in the group was 59.8 years.

Each of the 300 post-menopausal women took three cognitive tests: The Mini-Mental Statement Examination, a common test for evaluating the global cognitive status, a clock-drawing test to determine the women's executive function (planning, problem-solving, verbal reasoning, etc.); and the Boston Abbreviated Test to assess the women's memory.

The researchers found that BMI was positively correlated with higher levels of cognition. They also found an equal correlation between obesity-related waist circumference and global cognition.

But where does estrogen fit in? "Where there is increased adipose tissue , there is increased estrogen," said Dr. Zilberman. "My hypothesis is that estrogen may be protective of cognitive function in this case."

According to Dr. Zilberman, the possibility that naturally occurring estrogen from a woman's own fat cells may help preserve cognition flies in the face of current medical advice. "Based on previous studies, many research institutions have decided against recommending estrogens as a preventive intervention in cognitive impairment or dementia," she said. "That's what makes our findings so important."


'/>"/>
Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. WPI mathematics professor Dalin Tang elected a Fellow of the American Heart Association
2. 23andMe replicates over 180 genetic associations with Web-based research platform
3. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
4. BUSM professor selected as American Heart Association Distinguished Scientist
5. BUSM researcher to receive American Diabetes Associations highest honor
6. Patriot Data Solutions Group Selected to Assist Louisiana District Attorney Association with Pilot Project
7. NYU Langone experts present advances at American Association of Neurological Surgeons Meeting
8. University of Missouri professor elected to American Association for the Advancement of Science
9. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
10. Acceleron awarded $1.5 million grant from Muscular Dystrophy Association to support ACE-031
11. American Association of Anatomists announces young investigator award winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing ...  3D medical LCD display is the latest premium product recently added to the range ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), a ... webinar on Performing Quality Investigations: Getting to Root Cause. This ... charge. , Incomplete investigations are still a major concern to the Regulatory Authorities ...
Breaking Biology Technology: