Navigation Links
Association between menopause, obesity and cognitive impairment
Date:10/13/2011

Bethesda, Md. Obesity has been associated with cognitive decline, characterized by a deterioration of mental abilities that involve memory, language, and thought-processing speed. But in a study of 300 post-menopausal women included in the Cardiovascular Prevention Program "Corazn Sano," in Argentina, obese participants in the study performed better on three cognitive tests than participants of normal weight, leading researchers to speculate about the role of sex hormones and cognition.

According to the study's lead author, Judith M. Zilberman, MD, of the School of Pharmacy and Biochemistry's Department of Physiology, and the Instituto Cardiovascular de Buenos Aires, Argentina, these results may be attributable to estrogen stored and released by fat cells. Dr. Zilberman will discuss her team's findings at the Physiology of Cardiovascular Disease: Gender Disparities conference, October 12 at the University of Mississippi in Jackson. The conference is sponsored by the American Physiological Society with additional support from the American Heart Association. Her presentation is entitled, "Association Between Menopause, Obesity, and Cognitive Impairment."

The Study

The researchers reviewed the records of 678 women who had participated in Villa Mara, Crdoba. Of this number, 300 (44.3 percent) were identified as having been post-menopausal for at least 1 year. Of these, 158 women (52.6 percent) were also classified as obese either because of their waist circumference or body mass index (BMI). The average of the women in the group was 59.8 years.

Each of the 300 post-menopausal women took three cognitive tests: The Mini-Mental Statement Examination, a common test for evaluating the global cognitive status, a clock-drawing test to determine the women's executive function (planning, problem-solving, verbal reasoning, etc.); and the Boston Abbreviated Test to assess the women's memory.

The researchers found that BMI was positively correlated with higher levels of cognition. They also found an equal correlation between obesity-related waist circumference and global cognition.

But where does estrogen fit in? "Where there is increased adipose tissue , there is increased estrogen," said Dr. Zilberman. "My hypothesis is that estrogen may be protective of cognitive function in this case."

According to Dr. Zilberman, the possibility that naturally occurring estrogen from a woman's own fat cells may help preserve cognition flies in the face of current medical advice. "Based on previous studies, many research institutions have decided against recommending estrogens as a preventive intervention in cognitive impairment or dementia," she said. "That's what makes our findings so important."


'/>"/>
Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. WPI mathematics professor Dalin Tang elected a Fellow of the American Heart Association
2. 23andMe replicates over 180 genetic associations with Web-based research platform
3. NYU Langone Medical Centers tip sheet to the 2011 Alzheimers Association International Conference
4. BUSM professor selected as American Heart Association Distinguished Scientist
5. BUSM researcher to receive American Diabetes Associations highest honor
6. Patriot Data Solutions Group Selected to Assist Louisiana District Attorney Association with Pilot Project
7. NYU Langone experts present advances at American Association of Neurological Surgeons Meeting
8. University of Missouri professor elected to American Association for the Advancement of Science
9. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
10. Acceleron awarded $1.5 million grant from Muscular Dystrophy Association to support ACE-031
11. American Association of Anatomists announces young investigator award winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 This BCC Research ... market by reviewing the recent advances in high ... drive the field forward. Includes forecast through 2019. ... the challenges and opportunities that exist in the ... solution developers, as well as IT and bioinformatics ...
(Date:2/2/2016)...   Parabon NanoLabs (Parabon) announced today ... Office and the Defense Forensics and Biometrics Agency ... company,s Snapshot Kinship Inference software for ... defense-related DNA forensics.  Although Snapshot is best known ... ancestry from DNA evidence), it also has the ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
Breaking Biology News(10 mins):
(Date:2/11/2016)...   BioInformant announces the February 2016 release ... Opportunities, Tools, and Technologies – Market Size, Segments, Trends, ... The first and only market ... BioInformant has more than a decade of historical information ... stem cell type. This powerful 175 page global strategic ...
(Date:2/11/2016)... Miami (PRWEB) , ... February 11, 2016 , ... ... opening of its new stem cell treatment clinic in Quito, Ecuador. The new ... orthopedic and trauma applications to patients from around the world. , The ...
(Date:2/10/2016)... ANNAPOLIS, Md. , Feb. 10, 2016  The ... E. Busch , has announced that University of Maryland ... MD, PhD, MBA and University of Maryland Medical System ... recipients of the "Speaker,s Medallion," the highest honor given ... House of Delegates. Dean Reece and ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... that it has joined the Human Vaccines Project, a public-private partnership to ... cancer. , The Human Vaccines Project brings together leading pharmaceutical and ...
Breaking Biology Technology: