Navigation Links
Association between glioma susceptibility and XRCC1 Arg399Gln polymorphism

DNA damage is an important mechanism of glioma. X-ray cross-complementing group 1 (XRCC1) is a DNA repair gene that participates in the base excision repair pathway. To date, many studies have been performed to investigate the association between the XRCC1 polymorphisms and risk of cancers such as breast cancer, and gastroesophageal cancer, but the number of studies that focused on glioma is relatively small. Evidence regarding the role of the single nucleotide polymorphisms in XRCC1 as genetic markers for glioma risk is inconsistent. Prof. Xinquan Gu and team from China-Japan Union Hospital of Jilin University, China performed a meta-analysis to identify statistical evidence for an association between the XRCC1 Arg399Gln, Arg194Trp, Arg280His polymorphisms and glioma risk by accumulating all published data. Meta-analysis results verified that the XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility, especially in Asian populations. The Arg194Trp and Arg280His polymorphisms were found not to be associated with overall glioma risk. These findings, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), provide the necessary scientific basis for the glioma pathogenesis and glioma risk population screening.


Contact: Meng Zhao
Neural Regeneration Research

Page: 1

Related biology news :

1. 23andMe identifies 5 significant genetic associations for hypothyroidism
2. Amarantus BioSciences to Present at the National Investment Banking Associations (NIBA)122nd Conference in New York City
3. American Association for the Advancement of Science - Pacific Division convenes in Boise June 24-27
4. New research association started: Magnesium implants shall facilitate bone fracture healing
5. Pioneering researcher receives Heart Association Lifetime Achievement Award
6. Researchers sequence swine genome, discover associations that may advance animal and human health
7. Kansas State University scientists named American Association for the Advancement of Science fellows
8. UMass Medical School faculty elected to the American Association for the Advancement of Science
9. Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal
10. NREL employees honored by industry associations
11. New AAN/ALS Association Clinical Fellow Will Pursue Immune Biomarkers
Post Your Comments:
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 24, 2016  Regular discussions on a range of subjects ... the two entities said Poloz. Speaking at a ... , he pointed to the country,s inflation target, which ... "In certain areas ... have common economic goals, why not sit down and address ...
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
Breaking Biology Technology: