Navigation Links
Aspirin and atherosclerosis
Date:9/22/2008

Aspirin has become one of the most widely used medications in the world, owing to its ability to reduce pain, fevers, inflammation, and blood clotting. In animal studies, aspirin has also been shown to prevent atherosclerosis, though none of its known mechanisms of action would seem to account for this. In a new study, though, researchers have uncovered the mechanism that may explain aspirin's ability to prevent arterial plaque buildup.

Using cell culture and mouse models, Sampath Parthasarathy and colleagues observed that aspirin specifically its active byproduct salicylate can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 levels by 7- and 12- fold, respectively.

Both of these proteins are beneficial components of the HDL complex, the "good cholesterol" that helps prevent atherosclerosis; ApoA1 removes bad cholesterol from the bloodstream while PON1 is an antioxidant that breaks down toxic lipid peroxides.

The researchers also noted that the heightened expression of PON1 was accompanied by an increase in a receptor called AHR (aryl hydrocarbon receptor); this was intriguing as a chemical known to attach to AHR is resveratrol, the "heart healthy" component of red wine.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Plants in forest emit aspirin chemical to deal with stress; discovery may help agriculture
2. Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension
3. Failure to bridle inflammation spurs atherosclerosis
4. Lipoic acid could reduce atherosclerosis, weight gain
5. Nicotine may accelerate atherosclerosis, may be as dangerous as tar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... The Academy ... local celebration of National Model Aviation Day will take place from 9 a.m. to ... and will include activities for all ages. , Aviation Adventure Day will be packed ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... that has developed and intends both to manufacture and sell reagents used for ... NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual property and technologies ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies is proud ... installed a solar system on its roof top. “We will be independent of ... Kenneth Raab stated. The company’s proud history of social responsibility and participation in ...
(Date:7/13/2017)... ... July 13, 2017 , ... Heritage Biologics is ... is the independent leader in promoting healthcare quality through accreditation, certification and measurement. ... care, improved processes and better patient outcomes. , “Achieving URAC accreditation is ...
Breaking Biology Technology: