An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have developed a new method for discerning the functions of previously uncharacterized genes and placing them in interactive, functional networks that reveal how gene products interact to bring about cellular events.
The research is published in the April 29 issue of the journal Cell. It was led by principal investigators Karen Oegema, PhD, professor of cellular and molecular medicine and head of the Laboratory of Mitotic Mechanisms in the Ludwig Institute for Cancer Research at UC San Diego, and Kristin C. Gunsalus, PhD, assistant professor in the Center for Genomics and Systems Biology in the Department of Biology at New York University.
More than a decade of genome sequencing projects have generated a comprehensive "parts" list of the genes required to build an organism, an inventory of the necessary cellular building blocks. But the functions of many of these genes remain unknown, preventing researchers from fully deciphering their cellular pathways and how their interactions might shed light on human disease.
One of the stars of this research is Caenorhabditis elegans, a tiny, much-studied worm that is an important model system for understanding processes in animal cells. In recent years, scientists have sought to create systemic catalogs of its gene functions, and those of other model organisms. These large-scale efforts place genes in interactive networks. Within these networks, proximity reflects similarity of function. In other words, genes with similar functions are directly linked and genes with dissimilar functions are further apart. The functions of uncharacterized genes are inferred based upon their proximity to genes whose functions are known.
Generating functional maps with the power to resolve differences in gene function requires a lot of information, which is typically obtained by
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University of California - San Diego