Navigation Links
Arsenic for better drugs and cleaner crops
Date:6/25/2012

Research carried out at the University of Gothenburg may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.

Even though arsenic is toxic for many organs in the human body, it is used in the treatment of some forms of cancer, and it is an active component of drugs against parasitic diseases.

Healing arsenic

Arsenic is used in therapeutic medicine, but we know relatively little about the mechanisms by which cells develop resistance to arsenic, which may lead to a lower therapeutic effect.

Proteins control cellular processes

Scientist Doryaneh Ahmadpour at the Department of Chemistry and Molecular Biology, University of Gothenburg, has carried out experiments with common baker's yeast, in order to find out how inflow and outflow take place in cells.

"The knowledge we obtain from determining these mechanisms in yeast can be subsequently used in the long term to produce more effective drugs containing arsenic. A membrane protein known as Fps1 is particularly interesting. This protein transports the trivalent form of arsenic (arsenite) into and out from the cell," says Doryaneh Ahmadpour.

She has worked with scientist Michael Thorsen to show how the Fps1 protein is regulated and how the inflow into the cell of arsenic is influenced by another protein, Hog1.

The results suggest that a reduction in the activity of Hog1 is an effective way of increasing the ability of the cell to absorb arsenic. This may make the cell more sensitive to arsenic and thus give more effective treatment.

Resistance to arsenic can be increased in a similar manner, by increasing the activity of Hog1, which reduces the inflow of arsenic into the cells.

"We have shown also that a protein known as Slt2 regulates the outflow of arsenic from the cell, and increases the resistance of the c
'/>"/>

Contact: Doryaneh Ahmadpour
doryaneh.ahmadpour@cmb.gu.se
46-737-666-028
University of Gothenburg
Source:Eurekalert

Page: 1 2

Related biology news :

1. New methods for better purification of wastewater
2. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
3. UNH researchers find African farmers need better climate change data to improve farming practices
4. Giant squids giant eyes: The better to see hungry whales with
5. Improved loblolly pines better for the environment, study finds
6. Fish larvae find the reef by orienting: The earlier the better
7. Intensive kidney dialysis indicates better survival rates than conventional dialysis
8. Modern hybrid corn makes better use of nitrogen, study shows
9. Bigger gorillas better at attracting mates and raising young
10. Better housing conditions for zebrafish could improve research results
11. Better plants for biofuels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... DUBLIN , July 07, 2015 ... has announced the addition of the "Biometrics ... and Forecasts 2015-2020" report to their offering. ... a major contributor to this growth and the ... US$5.5 billion in revenue for companies involved in ...
(Date:7/8/2015)... , N.J. and NEW YORK , July ... Guidepoint today announced BD & Guidepoint ... companies with free access to Guidepoint,s expert network services. ... that are developing cutting-edge technologies to improve healthcare delivery ... Guidepoint research manager, each start-up entrepreneur will be able ...
(Date:7/7/2015)... 7, 2015  Based on its recent analysis ... recognizes Credence ID, LLC with the 2015 Asia-Pacific ... the Year Award. Credence ID has developed a ... mission of offering enrollment and identification solutions to ... ID was formed by experts from the mobile ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... a reason to be glad about madder: The climbing plant has ... Rice University and the City College of New York have discovered ... of purpurin, an organic dye that can be turned into a ... used since ancient times to create dye for fabrics. ...
... Troy, N.Y. A new study from engineering researchers ... how the little-understood protein osteocalcin plays a significant role ... lead to new strategies and therapeutics for fighting osteoporosis ... by the U.S. National Institutes of Health, the study ...
... Asian soybean rust ( Phakopsora pachyrhizi ) pose a ... because they can be blown great distances by the ... to determine whether these spores are viable. "Finding ... and able to infect plants," said USDA Agricultural Research ...
Cached Biology News:Rice cultivates green batteries from plant 2Rice cultivates green batteries from plant 3Battling brittle bones... with broccoli and spinach? 2Dead or alive? A new test to determine viability of soybean rust spores 2
(Date:8/3/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), a ... autologous cell therapies, announced today that RepliCel,s CEO, David ... in Minneapolis, Minnesota on August 5 ... highlight RepliCel,s 18-month milestones including CE Mark for its RCI-02 ... clinical data from both RCT-01 (tendon) and RCS-01 (skin) clinical ...
(Date:7/31/2015)... 31, 2015 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, ... today announced that the Company has filed its Annual ... Exchange Commission. The filed Form 20-F includes audited financial ... The Form 20-F can be accessed by visiting the ...
(Date:7/30/2015)... CAMBRIDGE, Mass. , July 30, 2015 /PRNewswire/ ... software solutions for the interpretation and analysis of ... Matthew Fischer has joined the company ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... astounding capabilities to integrate, interpret, analyze and explore ...
(Date:7/30/2015)... ... July 30, 2015 , ... Leading ... clinical study of its canine osteoarthritis stem cell product, currently under development for ... KS) and will be marketed in the US by Aratana. This product, termed ...
Breaking Biology Technology:RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3
... I am familiar with bad jobs. , ,My youngest brother ... involved wandering through unfamiliar neighborhoods, worrying about making a daily ... a shared apartment. After a few weeks of this, my ... brother once found a job selling environmentally friendly household products, ...
... the seed capital he needs to fuel his rapidly growing ... are legally allowed to make angel investments. , ,This is ... Wisconsins tech community, Peter M. Skanavis is doing everything he ... angel investments to actually take the plunge and put their ...
... stories coming out of California, but the failure of flight ... one of the weirdest. , ,The radio system used by ... a snit when its regular monthly maintenance wasnt performed and ... but couldnt talk to them, even as the planes converged ...
Cached Biology Technology:Beware the cold-call job interview 2Beware the cold-call job interview 3Beware the cold-call job interview 4Beware the cold-call job interview 5Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 2Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 3Investor profile: Peter M. Skanavis, tech angel, sees investing as civic duty 4Proactive nightmares 2
... The Mini-PROTEAN 3 Dodeca cell with multi-casting chamber ... up to 12 mini format handcast (8.3 x ... gels. The cell requires 3.4-4.4 L of buffer ... coil that attaches to an external refrigerated circulator ...
... a manual heat sealer ideal for low to ... can seal a wide range of plates of ... heating element of the sealer is pre-set for ... seals when used in conjunction with ABgenes sealing ...
...
...
Biology Products: