Navigation Links
Argonne scientists use lasers to align molecules
Date:5/13/2008

ARGONNE, Ill. (May 13, 2008) Protein crystallographers have only scratched the surface of the human proteins important for drug interactions because of difficulties crystallizing the molecules for synchrotron x-ray diffraction.

Scientists at the U.S. Department of Energy's (DOE) Argonne National Laboratory have devised a way to eliminate the need for crystallization by using lasers to align large groups of molecules.

"Strong laser fields can be used to control the behavior of atoms and molecules," Argonne Distinguished Fellow Linda Young said. "Using x-rays, we can investigate their properties in a totally new way."

Crystallization allows scientists to create a periodic structure that will strongly diffract in specific directions when bombarded with x-rays. From the resulting diffraction pattern, a real-space image can be reconstructed.

However, without crystallization, when x-rays collide with multiple, randomly oriented molecules, they diffract in different directions, making it impossible to create a composite diffraction image, Argonne Physicist Robin Santra said.

Some molecules, such as many involved with drug interaction, cannot be crystallized and imaging would require numerous samples to bombard in order to get a full composite picture. Young's laser technique allows for millions of molecules suspended in a gaseous state to be aligned so that when bombarded with x-rays, they all diffract in the same way. The resulting images are at atomic level resolution and do not require crystallization.

"Understanding the structure of the approximately 1 million human proteins that cannot be crystallized is perhaps the most important challenge facing structural biology," Young said.

"A method for structure determination at atomic resolution without the need to crystallize would be revolutionary."

Young and her team have successfully aligned molecules using a laser, probed the aligned ensemble with x-rays and shown theoretically that the technique could be used for x-ray imaging (See E. R. Peterson et al., Applied Physics Letters 92, 094106 (2008)), but they require an proposed upgrade to the Advanced Photon Source facility located at Argonne before x-ray diffraction can be done experimentally.


'/>"/>

Contact: Brock Cooper
bcooper@anl.gov
630-252-5565
DOE/Argonne National Laboratory
Source:Eurekalert

Related biology news :

1. Argonne scientists develop techniques for creating molecular movies
2. Bioinformatics technology developed at Argonne provides new insight into microbial activities
3. Research at Argonnes Advanced Photon Source reveals structure and behavior of collagen
4. New Argonne study may shed light on protein-drug interactions
5. Argonne National Lab acquires first SiCortex SC5832
6. Argonne helps China create cleaner Beijing for 2008 Olympics
7. Too hot to handle! Scientists identify heat sensing regulator
8. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
9. Scientists endure Arctic for last campaign prior to CryoSat-2 launch
10. Scientists discover why plague is so lethal
11. UF scientists discover compound that could lead to new blood pressure drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... MA (PRWEB) , ... May 23, 2017 , ... ... sources for advanced technology applications, has announced a facility expansion to accommodate its ... 3,000 square feet of new workspace and renovation of the existing areas. The ...
(Date:5/23/2017)... , ... May 23, 2017 , ... Cambridge Semantics ... splash at this year’s Bio-IT World Conference and Expo in Boston May ... Lake® 4.0 solution. The Anzo Smart Data Lake is also a finalist for ...
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore ... of the Maryland Biohealth community in developing and issuing recommendations to grow Maryland's ... BioHealth Innovation Hub by 2023. , The recommendations are contained ...
(Date:5/21/2017)... ... May 20, 2017 , ... ... the lengthy trial and error process by finding the right antidepressant faster. ... strengthen the doctor-patient relationship through a personalized approach to treatment. , ...
Breaking Biology Technology: